Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 • 1,829 citations

An Imbalance between the Excretion of Thromboxane and Prostacyclin Metabolites in Pulmonary Hypertension

1992 • 1,180 citations

Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?

1991 • 983 citations

Prostacyclin Synthase Expression Is Decreased in Lungs from Patients with Severe Pulmonary Hypertension

1999 • 788 citations

Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.

1995 • 770 citations

Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension.

1994 • 769 citations

Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.

1995 • 709 citations

Reduction in Pulmonary Vascular Resistance with Long-Term Epoprostenol (Prostacyclin) Therapy in Primary Pulmonary Hypertension

1998 • 674 citations

Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure.

1992 • 653 citations

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.

1995 • 590 citations

Increased plasma serotonin in primary pulmonary hypertension

1995 • 551 citations

Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.

1988 • 519 citations

Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia.

1993 • 445 citations

Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor

2000 • 373 citations

ENDOTHELIAL CELL RESPONSES TO HYPOXIC STRESS

1999 • 371 citations

CELLULAR AND MOLECULAR MECHANISMS OF PULMONARY VASCULAR REMODELING

1997 • 358 citations

Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Evidence for increased production of endothelin in pulmonary circulation.

1991 • 340 citations

Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension.

1993 • 337 citations

Background of Increased Flow Resistance and Vascular Reactivity in Spontaneously Hypertensive Rats

1970 • 328 citations

Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene

2000 • 318 citations

Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease

2000 • 305 citations

Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats

1995 • 298 citations

Three-Dimensional Reconstruction of Pulmonary Arteries in Plexiform Pulmonary Hypertension Using Cell-Specific Markers

1999 • 297 citations

The human pulmonary circulation

1987 • 283 citations

The Haemodynamic Consequences of Adaptive Structural Changes of the Resistance Vessels in Hypertension

1971 • 273 citations

Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia

1994 • 255 citations

A new role for an old molecule: serotonin as a mitogen

1997 • 253 citations

New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension.

1976 • 251 citations

Primary pulmonary hypertension and fenfluramine use.

1993 • 245 citations

Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension

1999 • 226 citations

Prolonged Administration of <scp>l</scp> -Arginine Ameliorates Chronic Pulmonary Hypertension and Pulmonary Vascular Remodeling in Rats

1997 • 223 citations

Elevated immunoreactive endothelin-1 levels in newborn infants with persistent pulmonary hypertension

1993 • 220 citations

Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension.

1995 • 211 citations

Induction of Serotonin Transporter by Hypoxia in Pulmonary Vascular Smooth Muscle Cells

1999 • 208 citations

Smooth Muscle Cells Isolated From Discrete Compartments of the Mature Vascular Media Exhibit Unique Phenotypes and Distinct Growth Capabilities

1997 • 208 citations

Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline.

1994 • 207 citations

Both membrane stretch and fatty acids directly activate large conductance Ca²⁺‐activated K⁺ channels in vascular smooth muscle cells

1992 • 204 citations

Prevention of Hypoxia-Induced Pulmonary Hypertension by Enhancement of Endogenous Heme Oxygenase-1 in the Rat

2000 • 204 citations

Hypoxia-induced structural changes in the media and adventitia of the rat hilar pulmonary artery and their regression.

1980 • 204 citations

Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m

1987 • 202 citations

Tenascin-C, proliferation and subendothelial fibronectin in progressive pulmonary vascular disease.

1997 • 194 citations

Pulmonary artery endothelial abnormalities in patients with congenital heart defects and pulmonary hypertension. A correlation of light with scanning electron microscopy and transmission electron microscopy.

1986 • 191 citations

Primary pulmonary hypertension

1998 • 187 citations

Cellular and molecular mechanisms in the pathogenesis of severe pulmonary hypertension

1995 • 185 citations

Tenascin-C Is Induced With Progressive Pulmonary Vascular Disease in Rats and Is Functionally Related to Increased Smooth Muscle Cell Proliferation

1996 • 183 citations

Increased Vascular Endothelial Growth Factor Production in the Lungs of Rats with Hypoxia-induced Pulmonary Hypertension

1998 • 183 citations

Role of angiotensin-converting enzyme and angiotensin II in development of hypoxic pulmonary hypertension

1995 • 183 citations

Normobaric hypoxia stimulates endothelin-1 gene expression in the rat

1992 • 182 citations

ETA-receptor antagonist prevents and reverses chronic hypoxia-induced pulmonary hypertension in rat

1995 • 170 citations

Primary pulmonary hypertension in a patient with a familial platelet storage pool disease: Role of serotonin

1990 • 159 citations

Endothelin-1 stimulates DNA synthesis and proliferation of pulmonary artery smooth muscle cells

1992 • 156 citations

A Pathophysiological Study of 10 Cases of Hypoxic Cor Pulmonale

1988 • 154 citations

Dual effect of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture.

1991 • 151 citations

Factors Influencing the Idiopathic Development of Pulmonary Hypertension in the Fawn Hooded Rat

1992 • 151 citations

Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension

1992 • 151 citations

Nitric Oxide and Endothelin-1 in Pulmonary Hypertension

1998 • 150 citations

Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular matrix-bound basic fibroblast growth factor

1996 • 147 citations

Endothelin-1 and Endothelin-3 Induce Chemotaxis and Replication of Pulmonary Artery Fibroblasts

1992 • 145 citations

Prostacyclin Analogues Differentially Inhibit Growth of Distal and Proximal Human Pulmonary Artery Smooth Muscle Cells

2000 • 145 citations

Hypoxia selectively induces proliferation in a specific subpopulation of smooth muscle cells in the bovine neonatal pulmonary arterial media.

1995 • 145 citations

Ca2+-channel blockers inhibit the action of recombinant platelet-derived growth factor in vascular smooth muscle cells.

1989 • 138 citations

Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension.

1997 • 136 citations

Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension

2000 • 136 citations

Continuous inhalation of nitric oxide protects against development of pulmonary hypertension in chronically hypoxic rats.

1994 • 135 citations

BQ123, an ET_A Receptor Antagonist, Inhibits Endothelin-1-mediated Proliferation of Human Pulmonary Artery Smooth Muscle Cells

1993 • 130 citations

The case for treatment of selected patients with primary pulmonary hypertension.

1986 • 128 citations

Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in hypoxic rats

1995 • 128 citations

Prolonged endothelin A receptor blockade attenuates chronic pulmonary hypertension in the ovine fetus.

1997 • 126 citations

Endothelin 1: Mitogenic Activity on Pulmonary Artery Smooth Muscle Cells and Release from Hypoxic Endothelial Cells

1992 • 126 citations

Increased Pulmonary Artery Elastolytic Activity in Adult Rats with Monocrotaline-induced Progressive Hypertensive Pulmonary Vascular Disease Compared with Infant Rats with Nonprogressive Disease

1992 • 125 citations

Regression of Hypertrophied Rat Pulmonary Arteries in Organ Culture Is Associated With Suppression of Proteolytic Activity, Inhibition of Tenascin-C, and Smooth Muscle Cell Apoptosis

1999 • 125 citations

Serotonin produces both hyperplasia and hypertrophy of bovine pulmonary artery smooth muscle cells in culture

1994 • 124 citations

Expression of pulmonary vascular angiotensin-converting enzyme in primary and secondary plexiform pulmonary hypertension

2000 • 123 citations

Collagen and elastin metabolism in hypertensive pulmonary arteries of rats.

1990 • 122 citations

BQ123, an ETA-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats

1994 • 122 citations

Chronic hypoxic pulmonary hypertension in rats and increased elastolytic activity

1991 • 122 citations

Continuous Nitric Oxide Inhalation Reduces Pulmonary Arterial Structural Changes, Right Ventricular Hypertrophy, and Growth Retardation in the Hypoxic Newborn Rat

1995 • 120 citations

Pressure-induced connective tissue synthesis in pulmonary artery segments is dependent on intact endothelium.

1989 • 114 citations

Excess collagen in hypertensive pulmonary arteries decreases vascular distensibility.

1994 • 112 citations

Alveolar Hypoxia Increases Gene Expression of Extracellular Matrix Proteins and Platelet-derived Growth Factor-B in Lung Parenchyma

1998 • 112 citations

The Orally Active Nonpeptide Endothelin A-Receptor Antagonist A-127722 Prevents and Reverses Hypoxia-Induced Pulmonary Hypertension and Pulmonary Vascular Remodeling in Sprague-Dawley Rats

1997 • 112 citations

Effect of Mechanical Forces on Growth and Matrix Protein Synthesis in the In Vitro Pulmonary Artery

1995 • 112 citations

Monocrotaline-Induced Pulmonary Fibrosis in Rats: Amelioration by Captopril and Penicillamine

1985 • 110 citations

Mechanical Properties and Reactivity of Vessels in Isolated Perfused Lungs of Chronically Hypoxic Rats

1981 • 105 citations

eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia

2000 • 105 citations

Enhanced expression of vascular endothelial growth factor in lungs of newborn infants with congenital diaphragmatic hernia and pulmonary hypertension

1999 • 104 citations

Prevention and reversal of hypoxic pulmonary hypertension by calcium antagonists.

1984 • 104 citations

Imbalance between Platelet Vascular Endothelial Growth Factor and Platelet-derived Growth Factor in Pulmonary Hypertension

2000 • 99 citations

Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats

1997 • 98 citations

Pulmonary Artery Remodeling Differs in Hypoxia- and Monocrotaline-induced Pulmonary Hypertension

1998 • 96 citations

Gene Transfer of Human Prostacyclin Synthase Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats

2000 • 95 citations

Alterations of growth factor transcripts in rat lungs during development of monocrotaline-induced pulmonary hypertension

1993 • 94 citations

Protection by oestradiol against the development of cardiovascular changes associated with monocrotaline pulmonary hypertension in rats

1993 • 94 citations

Increased expression of PDGF A- and B-chain genes in rat lungs with hypoxic pulmonary hypertension

1993 • 92 citations

Inhibition of elastolysis by SC-37698 reduces development and progression of monocrotaline pulmonary hypertension

1991 • 91 citations

Localization and Distribution of Endothelin Receptor Subtypes in Pulmonary Vasculature of Normal and Hypoxia-Exposed Rats

1999 • 91 citations

Prevention of pulmonary vascular changes of chronic alveolar hypoxia by inhibition of angiotensin I-converting enzyme in the rat.

1975 • 90 citations

Immediate-early gene expression in response to hypertrophic and proliferative stimuli in pulmonary arterial smooth muscle cells.

1994 • 89 citations

Inhibition of Tissue Angiotensin-Converting Enzyme With Quinapril Reduces Hypoxic Pulmonary Hypertension and Pulmonary Vascular Remodeling

1996 • 88 citations

Endothelial and subintimal changes in rat hilar pulmonary artery during recovery from hypoxia. A quantitative ultrastructural study.

1980 • 82 citations

Overexpression of endothelin-1 and enhanced growth of pulmonary artery smooth muscle cells from fawn-hooded rats

1996 • 80 citations

Hypoxia stimulates proliferation and interleukin-1α production in human vascular smooth muscle cells

1999 • 79 citations

Impairment of hypoxic pulmonary artery remodeling by heparin in mice.

1983 • 77 citations

Transforming growth factor-beta activity in sheep lung lymph during the development of pulmonary hypertension.

1990 • 77 citations

Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ETAreceptor antagonist

2000 • 76 citations

The orally active ET(A) receptor antagonist (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphe nyl-propionic acid (LU 135252) prevents the development of pulmonary hypertension and endothelial metabolic dysfunction in monocrotaline-treated rats.

1997 • 76 citations

Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture

1994 • 76 citations

Angiotensin II activates MAPK and stimulates growth of human pulmonary artery smooth muscle via AT₁receptors

1999 • 76 citations

Modulation of Angiotensin II Receptor Expression during Development and Regression of Hypoxic Pulmonary Hypertension

2000 • 75 citations

Decreased Arterial Wall Prostaglandin Production in Neonatal Calves with Severe Chronic Pulmonary Hypertension

1989 • 73 citations

Protein kinase C activation allows pulmonary artery smooth muscle cells to proliferate to hypoxia

1991 • 73 citations

Chronic inhaled nitric oxide: effects on pulmonary vascular endothelial function and pathology in rats

1996 • 72 citations

Nitric Oxide Inhalation Decreases Pulmonary Artery Remodeling in the Injured Lungs of Rat Pups

2000 • 70 citations

Amlodipine Inhibition of Serum-, Thrombin-, or Fibroblast Growth Factor-Induced Vascular Smooth-Muscle Cell Proliferation

1998 • 68 citations

Aerosol Gene Transfer With Inducible Nitric Oxide Synthase Reduces Hypoxic Pulmonary Hypertension and Pulmonary Vascular Remodeling in Rats

2000 • 67 citations

SC-39026, a serine elastase inhibitor, prevents muscularization of peripheral arteries, suggesting a mechanism of monocrotaline-induced pulmonary hypertension in rats.

1989 • 66 citations

Chronic Hypoxia Induces Exaggerated Growth Responses in Pulmonary Artery Adventitial Fibroblasts

2000 • 66 citations

Atrial natriuretic peptide attenuates the development of pulmonary hypertension in rats adapted to chronic hypoxia.

1990 • 66 citations

PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats

1992 • 64 citations

Arterial changes in Crotalaria spectabilis-induced pulmonary hypertension in rats.

1974 • 63 citations

Increased lung preproET-1 and decreased ET_B-receptor gene expression in fetal pulmonary hypertension

1998 • 63 citations

The Human Pulmonary Circulation. Its Form and Function in Health and Disease

1963 • 63 citations

Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline

1998 • 60 citations

The Effect of Nitric Oxide on Fetal Pulmonary Artery Smooth Muscle Growth

1995 • 60 citations

Angiotensin-converting Enzyme Inhibition Delays Pulmonary Vascular Neointimal Formation

1998 • 60 citations

Diverse Effects of Heparin on Mitogen-Activated Protein Kinase–Dependent Signal Transduction in Vascular Smooth Muscle Cells

1997 • 60 citations

Stretch increases inositol trisphosphate and inositol tetrakisphosphate in cultured pulmonary vascular smooth muscle cells

1991 • 59 citations

Alteration of the pulsatile load in the high-altitude calf model of pulmonary hypertension

1991 • 59 citations

Early pulmonary vascular changes in congenital heart disease studied in biopsy tissue.

1980 • 59 citations

Effect of hypoxia on prostacyclin production in cultured pulmonary artery endothelium

1986 • 58 citations

Reduction of chronic hypoxic pulmonary hypertension in the rat by an inhibitor of collagen production.

1987 • 56 citations

Vascular remodeling and ET-1 expression in rat strains with different responses to chronic hypoxia

2000 • 55 citations

Angiotensin II receptor expression and inhibition in the chronically hypoxic rat lung

1996 • 54 citations

Nitric oxide reduces vascular smooth muscle cell elastase activity through cGMP‐mediated suppression of ERK phosphorylation and AML1B nuclear partitioning

2000 • 53 citations

Platelet‐derived growth factor and angiotensin II cause increases in cytosolic free calcium by different mechanisms in vascular smooth muscle cells

1989 • 53 citations

Pulmonary arteries and veins in experimental hypoxia. An ultrastructural study.

1978 • 52 citations

Reduced oxygen tension induces pulmonary endothelium to release a pulmonary smooth muscle cell mitogen(s).

1987 • 51 citations

Insulin‐Like growth factor I and protein kinase C activation stimulate pulmonary artery smooth muscle cell proliferation through separate but synergistic pathways

1990 • 50 citations

Heterogeneity in the proliferative response of bovine pulmonary artery smooth muscle cells to mitogens and hypoxia: importance of protein kinase C

1997 • 50 citations

Reduction of chronic hypoxic pulmonary hypertension in the rat by beta-aminopropionitrile

1984 • 50 citations

Pulmonary Hypertensive Diseases

1984 • 49 citations

Inhibition of hypoxic pulmonary hypertension by heparins of differing in vitro antiproliferative potency.

1994 • 49 citations

Recognition and Management of Pulmonary Hypertension

1998 • 48 citations

Action of dihydropyridine calcium antagonists on early growth response gene expression and cell growth in vascular smooth muscle cells

1993 • 48 citations

Expression of endothelin-1 in rats developing hypobaric hypoxia-induced pulmonary hypertension.

1999 • 47 citations

Urinary Nitrite and Nitrate Concentrations in Patients with Idiopathic Persistent Pulmonary Hypertension of the Newborn and Effect of Extracorporeal Membrane Oxygenation

1995 • 47 citations

Pulmonary Artery Pressure in Rats with Hereditary Platelet Function Defect

1988 • 46 citations

Angiotensin converting enzyme expression in primary pulmonary hypertension.

1996 • 46 citations

Neutral Endopeptidase 24.11 Inhibition Reduces Pulmonary Vascular Remodeling in Rats Exposed to Chronic Hypoxia

1991 • 44 citations

Role of inhibition of nitric oxide production in monocrotaline-induced pulmonary hypertension

1997 • 43 citations

Role of Nitric Oxide in Regulating Neonatal Porcine Pulmonary Artery Smooth Muscle Cell Proliferation

1999 • 42 citations

Insulin-like Growth Factor I and Pulmonary Hypertension Induced by Continuous Air Embolization in Sheep

1992 • 42 citations

Stretching increases calcium influx and efflux in cultured pulmonary arterial smooth muscle cells

1992 • 42 citations

Endothelin-Induced Collagen Remodeling in Experimental Pulmonary Hypertension

1995 • 42 citations

Effects of Cilazapril, a Novel Angiotensin Converting Enzyme Inhibitor, on the Structure of Pulmonary Arteries of Rats Exposed to Chronic Hypoxia

1991 • 40 citations

Pulmonary artery smooth muscle cells from chronically hypoxic neonatal calves retain fetal-like and acquire new growth properties

1997 • 40 citations

Primary pulmonary hypertension.

2000 • 40 citations

Characterization of fibroblast mitogens and chemoattractants produced by endothelial cells exposed to hypoxia.

1994 • 39 citations

Effect of Heparin and Warfarin on Chronic Hypoxie Pulmonary Hypertension and Vascular Remodeling in the Guinea Pig

1989 • 38 citations

Angiotensin II and monocrotaline-induced pulmonary hypertension: effect of losartan (DuP 753), a nonpeptide angiotensin type 1 receptor antagonist.

1992 • 38 citations

E-4010, a selective phosphodiesterase 5 inhibitor, attenuates hypoxic pulmonary hypertension in rats

1999 • 38 citations

Endothelin-1 Activates MAP Kinases and c-Jun in Pulmonary Artery Smooth Muscle

1998 • 38 citations

Failure to show decrease in small pulmonary blood vessels in rats with experimental pulmonary hypertension.

1982 • 37 citations

QUANTITATIVE CHANGES IN THE RAT PULMONARY VASCULATURE IN CHRONIC HYPOXIA ‐ RELATION TO HAEMODYNAMIC CHANGES

1986 • 37 citations

Basic Fibroblast Growth Factor Alterations During Development of Monocrotaline-Induced Pulmonary Hypertension in Rats

1995 • 37 citations

Improvement of mortality by long-term E4010 treatment in monocrotaline-induced pulmonary hypertensive rats.

1999 • 34 citations

Continuous low-dose NO inhalation does not prevent monocrotaline-induced pulmonary hypertension in rats

1997 • 33 citations

Prolonged Inhaled NO Attenuates Hypoxic, but Not Monocrotaline-Induced, Pulmonary Vascular Remodeling in Rats

1998 • 33 citations

Transforming growth factor-beta 1 is decreased in remodeling hypertensive bovine pulmonary arteries.

1992 • 32 citations

Combined therapy with zaprinast and inhaled nitric oxide abolishes hypoxic pulmonary hypertension

2000 • 32 citations

Perindopril, an angiotensin converting enzyme inhibitor, in pulmonary hypertensive rats: comparative effects on pulmonary vascular structure and function

1999 • 31 citations

Plasma endothelin-1 levels in patients with left-to-right shunt with or without pulmonary hypertension

1999 • 31 citations

Nitrendipine attenuates the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia in rats.

1986 • 31 citations

Estradiol improves pulmonary hemodynamics and vascular remodeling in perinatal pulmonary hypertension

2000 • 29 citations

LU135252, an endothelin_A receptor antagonist did not prevent pulmonary vascular remodelling or lung fibrosis in a rat model of myocardial infarction

2000 • 29 citations

The Prostacyclin-Mimetic Cicaprost Inhibits Endogenous Endothelin-1 Release From Human Pulmonary Artery Smooth Muscle Cells

2000 • 27 citations

Polyamines and Epidermal Growth Factor in Monocrotaline-induced Pulmonary Hypertension

1989 • 27 citations

Development of Monocrotaline-Induced Pulmonary Hypertension Is Attenuated by a Serotonin Receptor Antagonist

2000 • 26 citations

Endothelin converting enzyme inhibitor protects development of right ventricular overload and medial thickening of pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension

1998 • 25 citations

Effect of DMPPO, a phosphodiesterase type 5 inhibitor, on hypoxic pulmonary hypertension in rats

1998 • 24 citations

Hypoxia-Induced Release of Peptide Growth Factors from Neonatal Porcine Pulmonary Artery Smooth Muscle Cells

1999 • 24 citations

Hypoxic pulmonary vasoconstriction in chronically hypoxic rats

1984 • 23 citations

Neutral endopeptidase inhibition attenuates development of hypoxic pulmonary hypertension in rats

1993 • 22 citations

A selective type V phosphodiesterase inhibitor, E4021, protects the development of right ventricular overload and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension

1996 • 22 citations

Nitric Oxide Impacts Endothelin-1 Gene Expression in Intrapulmonary Arteries of Chronically Hypoxic Rats

1999 • 21 citations

Inhibition of PDGF-Mediated Proliferation of Vascular Smooth Muscle Cells by Calcium Antagonists

1997 • 20 citations

Chronic Hypoxia-Induced Cardiopulmonary Changes in Three Rat Strains: Inhibition by the Endothelin Receptor Antagonist SB 217242

1998 • 20 citations

Pulmonary hypertension--advances in medical and surgical interventions.

1998 • 18 citations

Lung angiotensin receptor binding characteristics during the development of monocrotaline-induced pulmonary hypertension

1997 • 17 citations

Inhibitory Effect of Heparin on Serotonin-induced Hyperplasia and Hypertrophy of Smooth Muscle Cells

1997 • 17 citations

Effects of Tetrandrine on Growth Factor-induced DNA Synthesis and Proliferative Response of Rat Pulmonary Artery Smooth Muscle Cells

2000 • 17 citations

Mechanism of action of the inhibitory effect of nifedipine on the growth of cultured aortic cells from spontaneously hypertensive and normotensive rats

1995 • 17 citations

Role of endothelial cells in the proliferative response of cultured pulmonary vascular smooth muscle cells to reduced oxygen tension

1992 • 16 citations

Decreased Cytosolic free Calcium Concentration in Lymphocytes of Magnesium-supplemented Doca-Salt Hypertensive Rats

1989 • 16 citations

Pulmonary vascular remodelling in hypoxic rats: effects of amlodipine, alone and with perindopril

2001 • 15 citations

Effect of alveolar pressure on pulmonary artery pressure in chronically hypoxic rats

1987 • 15 citations

SUPPRESSION OF VASCULAR TRANSFORMING GROWTH FACTOR‐β₁ AND EXTRACELLULAR MATRIX GENE EXPRESSIONS BY CILAZAPRIL AND NIFEDIPINE IN HYPERTENSIVE RATS

1995 • 15 citations

Heparin-like molecules inhibit pulmonary vascular pericyte proliferation in vitro

2000 • 15 citations

ZD1611, an Orally Active Endothelin-A Receptor Antagonist, Prevents Chronic Hypoxia-induced Pulmonary Hypertension in the Rat

1999 • 14 citations

Pulmonary Circulation: A Handbook for Clinicians

1999 • 14 citations

The Pulmonary Hypertensive Fawn-hooded Rat Has a Normal Serotonin Transporter Coding Sequence

1998 • 14 citations

Pulmonary vascular remodelling

1995 • 14 citations

The effect of heparin on the haemodynamic and structural response in the rat to acute and chronic hypoxia.

1989 • 13 citations

Semotiadil inhibits the development of right ventricular hypertrophy and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension

1995 • 12 citations

Amlodipine and vascular hypertrophy

1997 • 12 citations

PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model

1992 • 12 citations

Identification of stretch-responsive genes in pulmonary artery smooth muscle cells by a two arbitrary primer-based mRNA differential display approach.

1999 • 11 citations

Effects of SCH 34826, a neutral endopeptidase inhibitor, on hypoxic pulmonary vascular remodelling

1992 • 10 citations

Monocrotaline-induced cardiopulmonary injury in rats: modification by the nonthiol ACE inhibitors CGS13945 and CGS16617.

1988 • 10 citations

Pathogenesis of Pulmonary Hypertension in the Rat Model

1988 • 10 citations

Pulmonary Circulation-A Handbook for Clinicians

1996 • 10 citations

The Human Pulmonary Circulation: its Form and Function in Health and Disease

1987 • 7 citations

Neither anticoagulant nor nonanticoagulant heparin affects monocrotaline lung injury

1987 • 6 citations

The effect of nifedipine on monocrotaline‐induced pulmonary hypertension in rats

1993 • 6 citations

Heterogeneity in the proliferative response of bovine pulmonary artery smooth muscle cells to mitogens and hypoxia: importance of protein kinase C

1997 • 6 citations

Clinical pulmonary hypertension

1995 • 5 citations

The Effect of the ETAReceptor Antagonist (CI-1020) in Rats with Established Hypoxic Pulmonary Hypertension

1998 • 5 citations

Clinical pulmonary hypertension

1986 • 2 citations