Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5`-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Exploratory Data Analysis

1977 • 12,265 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Exploratory Data Analysis.

1978 • 2,890 citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 • 1,829 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

1995 • 1,366 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?

1991 • 983 citations

Inhaled nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 865 citations

Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 731 citations

Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.

1991 • 691 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

Molecular characterization of endothelin receptors

1992 • 601 citations

Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth

1990 • 447 citations

Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia.

1993 • 445 citations

Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass.

1993 • 371 citations

Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide

1993 • 331 citations

Inhaled nitric oxide in infants referred for extracorporeal membrane oxygenation: Dose response

1994 • 267 citations

Persistent pulmonary hypertension of the newborn infant

1976 • 264 citations

Acute effects of inhaled nitric oxide in children with severe hypoxemic respiratory failure

1994 • 223 citations

Elevated immunoreactive endothelin-1 levels in newborn infants with persistent pulmonary hypertension

1993 • 220 citations

Rapid release of endothelin and ATP from isolated aortic endothelial cells exposed to increased flow

1990 • 211 citations

Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb.

1993 • 204 citations

Inhaled nitric oxide in the treatment of postoperative graft dysfunction after lung transplantation

1994 • 193 citations

Endothelium-dependent relaxation and cyclic GMP accumulation in rabbit pulmonary artery are selectively impaired by moderate hypoxia.

1989 • 172 citations

Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs.

1994 • 170 citations

Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells.

1994 • 169 citations

Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension

1992 • 151 citations

Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation.

1994 • 138 citations

Plasma nitric oxide levels in newborn infants with sepsis

1993 • 133 citations

Hemodynamic effects of exogenous nitric oxide in ovine transitional pulmonary circulation

1992 • 130 citations

Increased plasma levels of endothelin-1 after cardiopulmonary bypass in patients with pulmonary hypertension and congenital heart disease

1993 • 128 citations

Maturational changes in endothelium-derived relaxing factor activity of ovine pulmonary arteries in vitro

1991 • 125 citations

Endothelium-dependent relaxation and cyclic GMP accumulation in rabbit pulmonary artery are selectively impaired by moderate hypoxia.

1989 • 109 citations

Plasma endothelin levels are increased during septic shock

1992 • 91 citations

Arginine Deficiency Accompanies Persistent Pulmonary Hypertension of the Newborn

1994 • 90 citations

Relation of elevated plasma endothelin in congenital heart disease to increased pulmonary blood flow

1993 • 87 citations

Endothelin 1 mediates ex vivo coronary vasoconstriction caused by exogenous and endogenous cytokines.

1995 • 87 citations

Whole Body Arginine Metabolism and Nitric Oxide Synthesis in Newborns with Persistent Pulmonary Hypertension

1995 • 82 citations

EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs

1992 • 68 citations

Endothelium-Dependent Contractions

1991 • 66 citations

Effect of <i>L</i>-Arginine Infusion on Infants with Persistent Pulmonary Hypertension of the Newborn

1995 • 58 citations

The Role of Endothelin and Endothelin Receptor Subtypes in Regulation of Fetal Pulmonary Vascular Tone

1994 • 57 citations

Activation of Soluble Guanylyl Cyclase by a Factor Other Than Nitric Oxide or Carbon Monoxide Contributes to the Vascular Hyporeactivity to Vasoconstrictor Agents in the Aorta of Rats Treated with Endotoxin

1994 • 53 citations

Fetal endothelin levels and placental vascular endothelin receptors in intrauterine growth retardation

1994 • 50 citations

Pulmonary Vascular Reactivity to Endothelin-1 in Normal and Chronically Pulmonary Hypertensive Rats

1991 • 45 citations

Concentrations of Endothelin-1 in Maternal and Umbilical Cord Blood at Various Stages of Pregnancy

1991 • 32 citations

Circulating levels of endothelin and atrial natriuretic factor during postnatal life

1992 • 19 citations