Sildenafil-mediated reduction in retinal function in heterozygous mice lacking the gamma-subunit of phosphodiesterase.

Oral Sildenafil in the Treatment of Erectile Dysfunction

1998 • 2,097 citations

Cyclic GMP synthesis and function.

1987 • 871 citations

EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES

1998 • 595 citations

Clinical safety of oral sildenafil citrate (VIAGRATM) in the treatment of erectile dysfunction

1998 • 466 citations

Cyclic Guanosine Monophosphate: Elevation in Degenerating Photoreceptor Cells of the C3H Mouse Retina

1974 • 412 citations

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

1999 • 397 citations

Population genetic studies of retinitis pigmentosa.

1980 • 298 citations

Autosomal recessive retinitis pigmentosa caused by mutations in the α subunit of rod cGMP phosphodiesterase

1995 • 244 citations

Cyclic GMP Accumulation Causes Degeneration of Photoreceptor Cells: Simulation of an Inherited Disease

1977 • 232 citations

Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse.

1998 • 219 citations

Role for the Target Enzyme in Deactivation of Photoreceptor G Protein in Vivo

1998 • 205 citations

Retinal Degeneration in Mice Lacking the γ Subunit of the Rod cGMP Phosphodiesterase

1996 • 178 citations

The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone.

1993 • 169 citations

Sildenafil (Viagra) and Ophthalmology

1999 • 167 citations

Frequency of mutations in the gene encoding the alpha subunit of rod cGMP-phosphodiesterase in autosomal recessive retinitis pigmentosa.

1999 • 134 citations

Electroretinographic Testing as an Aid in Detection of Carriers of X-Chromosome-Linked Retinitis Pigmentosa

1979 • 124 citations

Sensitivity of photoreceptors to elevated levels of cGMP in the human retina.

1980 • 104 citations

Sildenafil (Viagra) and Ophthalmology

1999 • 61 citations

Rod and cone system contributions to oscillatory potentials: An explanation for the conditioning flash effect

1987 • 60 citations

Retarding photoreceptor degeneration in Pdegtm1/Pdegtml mice by an apoptosis suppressor gene.

1997 • 46 citations

The influence of phosphodiesterase inhibitors on ERG and optic nerve response of the cat.

1986 • 38 citations

Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa.

1994 • 25 citations

A point mutation (W70A) in the rod PDE-gamma gene desensitizing and delaying murine rod photoreceptors.

1999 • 24 citations

The oscillatory potentials in response to stimuli of photopic intensities delivered in dark-adaptation: An explanation for the conditioning flash effect

1990 • 20 citations