Epigenetic silencing of multiple interferon pathway genes after cellular immortalization

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Analysis of Variance for Gene Expression Microarray Data

2000 • 1,339 citations

Telomere elongation in immortal human cells without detectable telomerase activity.

1995 • 1,249 citations

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1997 • 1,244 citations

Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

2001 • 923 citations

Telomere maintenance by recombination in human cells

2000 • 844 citations

Microarray analysis of replicative senescence

1999 • 741 citations

Germline mutations in the ribonuclease L gene in families showing linkage with HPC1

2002 • 525 citations

Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2

1993 • 449 citations

Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

1993 • 392 citations

Genetic analysis of indefinite division in human cells: identification of four complementation groups.

1988 • 358 citations

Evidence for the Recessive Nature of Cellular Immortality

1983 • 286 citations

DNA Methylation and Silencing of Gene Expression

2000 • 276 citations

Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma

1997 • 255 citations

Alterations in p53 and p16^INK4 Expression and Telomere Length during Spontaneous Immortalization of Li-Fraumeni Syndrome Fibroblasts

1995 • 248 citations

The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region

1997 • 247 citations

Limited and unlimited growth of sv40-transformed cells from human diploid mrc-5 fibroblasts

1983 • 241 citations

The Cell Biology of Human Aging

1976 • 235 citations

Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells

1999 • 197 citations

PKR, apoptosis and cancer

1999 • 193 citations

Promoter-Region Hypermethylation and Gene Silencing in Human Cancer

2000 • 154 citations

Spontaneous In Vitro Immortalization of Breast Epithelial Cells from a Patient with Li-Fraumeni Syndrome

1995 • 152 citations

Nuclear targets for transcription regulation by oncogenes

1991 • 147 citations

Immunization of mice against tetanus with fragments of tetanus toxin synthesized in Escherichia coli

1987 • 120 citations

Novel Pathways Associated with Bypassing Cellular Senescence in Human Prostate Epithelial Cells

2002 • 116 citations

p53 and the Li-Fraumeni syndrome

1994 • 116 citations

Statistical intelligence: effective analysis of high-density microarray data

2002 • 110 citations

Binding of an Interferon-inducible Protein (p202) to the Retinoblastoma Protein

1995 • 110 citations

Stat1-Dependent, p53-Independent Expression of p21^waf1 Modulates Oxysterol-Induced Apoptosis

2002 • 99 citations

CpG island methylation of the hTERT promoter is associated with lower telomerase activity in B-cell lymphocytic leukemia

2002 • 72 citations

The Gene Encoding p202, an Interferon-inducible Negative Regulator of the p53 Tumor Suppressor, Is a Target of p53-mediated Transcriptional Repression

2001 • 72 citations

DNA Methyltransferase Inhibition in Normal Human Fibroblasts Induces a p21-dependent Cell Cycle Withdrawal

2001 • 70 citations

The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader–Willi syndrome deletion region

1998 • 70 citations

Telomerase activity during spontaneous immortalization of Li-Fraumeni syndrome skin fibroblasts

1998 • 60 citations

Senescence and immortalization of human cells.

2000 • 45 citations

The Genetics of Cellular Senescence

1998 • 38 citations

Melanoma-Reactive CD8 + T Cells Recognize a Novel Tumor Antigen Expressed in a Wide Variety of Tumor Types

2001 • 33 citations

Epigenetic cancer therapies: DNA methyltransferase inhibitors

2002 • 33 citations

p202, an interferon-inducible negative regulator of cell growth, is a target of the adenovirus E1A protein

2001 • 29 citations