The Genetics of Cellular Senescence

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

Positional Cloning of the Werner's Syndrome Gene

1996 • 1,696 citations

Telomere end-replication problem and cell aging

1992 • 1,044 citations

Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression

1996 • 549 citations

The biology of replicative senescence

1997 • 511 citations

Defining the molecular mechanisms of human cell immortalization

1991 • 384 citations

Telomeres and telomerase in aging and cancer

1995 • 328 citations

Increased activity of p53 in senescing fibroblasts.

1995 • 303 citations

Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation

1996 • 303 citations

Telomeres, telomerase and senescence

1990 • 260 citations

Telomere dynamics and telomerase activity in in vitro immortalised human cells

1997 • 218 citations

Senescent Human Diploid Cells in Culture: Survival, DNA Synthesis and Morphology

1979 • 152 citations

Extension of the Replicative Life Span of Human Diploid Fibroblasts by Inhibition of the p33^ING1 Candidate Tumor Suppressor

1997 • 151 citations

Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1.

1993 • 109 citations

Replicative Senescence in the Immune System: Impact of the Hayflick Limit on T-Cell Function in the Elderly

1998 • 101 citations

Senescence of immortal human fibroblasts by the introduction of normal human chromosome 6.

1994 • 97 citations

Multiple pathways for the regulation of telomerase activity

1997 • 93 citations

Multiple pathways to cellular senescence: Role of telomerase repressors

1997 • 86 citations

Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1.

1995 • 77 citations

Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)

1997 • 77 citations

Cellular Aging in Werner's Syndrome: A Unique Phenotype?

1979 • 72 citations

Causes, Effects, and Constraints in the Genetics of Human Longevity

1998 • 55 citations

Genetic Complementation of the Immortal Phenotype in Group D Cell Lines by Introduction of Chromosome 7

1995 • 32 citations

Chromosome 7 Suppresses Indefinite Division of Nontumorigenic Immortalized Human Fibroblast Cell Lines KMST-6 and SUSM-1

1993 • 32 citations

Hybrids from fusion of normal human T lymphocytes with immortal human cells exhibit limited life span

1990 • 25 citations

The implications of telomerase biochemistry for human disease

1997 • 24 citations

Evidence for two senescence loci on human chromosome I

1996 • 23 citations

Escape from senescence in hybrid cell clones involves deletions of two regions located on human chromosome 1q.

1996 • 12 citations