DNA Methyltransferase Inhibition in Normal Human Fibroblasts Induces a p21-dependent Cell Cycle Withdrawal

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Cancer-epigenetics comes of age

1999 • 2,379 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Inhibition of telomerase limits the growth of human cancer cells

1999 • 1,032 citations

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

2000 • 1,024 citations

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

2000 • 960 citations

Bypass of Senescence After Disruption of p21 ^CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

1997 • 797 citations

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1999 • 695 citations

DNA Methylation Decreases in Aging But Not in Immortal Cells

1983 • 635 citations

Recombinant Human DNA (Cytosine-5) Methyltransferase

1999 • 624 citations

p21 ^WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells

1998 • 530 citations

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl

1997 • 509 citations

Histone Deacetylase Inhibition Selectively Alters the Activity and Expression of Cell Cycle Proteins Leading to Specific Chromatin Acetylation and Antiproliferative Effects

1999 • 394 citations

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

1999 • 384 citations

Failure to Phosphorylate the Retinoblastoma Gene Product in Senescent Human Fibroblasts

1990 • 367 citations

Subsenescent Telomere Lengths in Fibroblasts Immortalized by Limiting Amounts of Telomerase

2000 • 263 citations

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G ₁ arrest after γ-irradiation

1999 • 259 citations

Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.

1996 • 237 citations

Role of DNA 5-Methylcytosine Transferase in Cell Transformation by fos

1999 • 237 citations

Cellular Senescence revisited: a review

1987 • 171 citations

DNA methylation in aging of mice

1987 • 157 citations

Regulation of the DNA Methyltransferase by the Ras-AP-1 Signaling Pathway

1995 • 136 citations

Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA.

1995 • 120 citations

The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation

1987 • 119 citations

Down-regulation of Human DNA-(Cytosine-5) Methyltransferase Induces Cell Cycle Regulators p16 and p21WAF/Cip1 by Distinct Mechanisms

1999 • 113 citations

DNA Methyltransferase Inhibition Induces the Transcription of the Tumor Suppressor p21

2000 • 112 citations

DNA Methyltransferase Is a Downstream Effector of Cellular Transformation Triggered by Simian Virus 40 Large T Antigen

1999 • 95 citations

Reinitiation of cellular DNA synthesis in BrdU‐selected nondividing senescent WI‐38 cells by simian virus 40 infection

1985 • 90 citations

Mouse DNA methylase: Methylation of native DNA

1979 • 86 citations

Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts.

1994 • 69 citations

Phenotype of low proliferative potential is dominant in hybrids of normal human fibroblasts

1982 • 67 citations

Age-related methylation changes in DNA may reflect the proliferative potential of organs

1989 • 54 citations

Epigenetic aspects of cellular senescence

2000 • 36 citations

Demethylation of satellite I DNA during senescence of bovine adrenocortical cells in culture

1992 • 33 citations