Novel Pathways Associated with Bypassing Cellular Senescence in Human Prostate Epithelial Cells

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

In silico prediction of protein-protein interactions in human macrophages

2014 • 11,120 citations

Significance analysis of microarrays applied to the ionizing radiation response

2001 • 10,393 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Systematic variation in gene expression patterns in human cancer cell lines

2000 • 2,119 citations

Use of a cDNA microarray to analyse gene expression patterns in human cancer

1996 • 2,002 citations

The Transcriptional Program in the Response of Human Fibroblasts to Serum

1999 • 1,994 citations

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

2001 • 1,584 citations

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

1999 • 1,483 citations

Continuous Fluorescence Monitoring of Rapid Cycle DNA Amplification

2013 • 1,263 citations

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

1998 • 1,206 citations

Continuous Fluorescence Monitoring of Rapid Cycle DNA Amplification

1997 • 1,113 citations

Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification.

1998 • 973 citations

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1998 • 912 citations

Cellular senescence as a tumor-suppressor mechanism

2001 • 847 citations

Senescence of human fibroblasts induced by oncogenic Raf

1998 • 805 citations

Bypass of Senescence After Disruption of p21 ^CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

1997 • 797 citations

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

1991 • 592 citations

Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis

2000 • 511 citations

Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice

1997 • 400 citations

Cellular senescence, cancer and aging: the telomere connection

2001 • 392 citations

Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14^ARF Tumor Suppressor

2000 • 391 citations

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

1999 • 380 citations

Cancer, aging and cellular senescence.

2000 • 369 citations

Genetic analysis of indefinite division in human cells: identification of four complementation groups.

1988 • 358 citations

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

1998 • 305 citations

Molecules in focus Insulin-like growth factor II (IGF-II)

1998 • 304 citations

Aging and Cancer: The Double‐Edged Sword of Replicative Senescence

1997 • 246 citations

Arrest of G₁-S Progression by the p53-Inducible Gene PC3 Is Rb Dependent and Relies on the Inhibition of Cyclin D1 Transcription

2000 • 226 citations

The insulin-like growth factor axis and prostate cancer: lessons from the transgenic adenocarcinoma of mouse prostate (TRAMP) model.

1999 • 214 citations

Insulin-Like Growth Factor Binding Proteins: New Proteins, New Functions

1999 • 213 citations

Molecular Cloning of Differentially Expressed Genes in Human Epithelial Ovarian Cancer

1994 • 183 citations

In Vivo Expression of the Novel CXC Chemokine BRAK in Normal and Cancerous Human Tissue

2000 • 180 citations

Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells.

1996 • 176 citations

Alteration of the tumor suppressor gene p53 in a high fraction of hormone refractory prostate cancer.

1995 • 162 citations

p16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells.

1999 • 162 citations

Genomewide Scan for Prostate Cancer–Aggressiveness Loci

2000 • 160 citations

Overcoming cellular senescence in human cancer pathogenesis

1998 • 152 citations

The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis

1998 • 147 citations

RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage

2001 • 146 citations

Alteration of the Tumor Suppressor Gene p53 in a High Fraction of Hormone Refractory Prostate Cancer

1995 • 136 citations

Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells.

1994 • 130 citations

Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts.

1998 • 123 citations

Regulation of two E2F-related genes in presenescent and senescent human fibroblasts.

1994 • 121 citations

Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells

2001 • 104 citations

Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3

2000 • 91 citations

Growth kinetics and differentiation in vitro of normal human uroepithelial cells on collagen gel substrates in defined medium

1987 • 88 citations

Discovery of new DNA amplification loci in prostate cancer by comparative genomic hybridization

2001 • 82 citations

rhoB Encoding a UV-inducible Ras-related Small GTP-binding Protein Is Regulated by GTPases of the Rho Family and Independent of JNK, ERK, and p38 MAP Kinase

1997 • 79 citations

Evidence for multiple pathways to cellular senescence.

1994 • 78 citations

Different combinations of genetic/epigenetic alterations inactivate the p53 and pRb pathways in invasive human bladder cancers.

2000 • 58 citations

QUANTITATIVE IMMUNOHISTOCHEMICAL ANALYSIS OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 IN HUMAN PROSTATIC ADENOCARCINOMA: A PROGNOSTIC STUDY

1998 • 46 citations

Apoptosis in human papillomavirus16 E7-, but not E6-immortalized human uroepithelial cells.

1996 • 43 citations

Kallikrein in the Male Reproductive System

1987 • 19 citations

Cell immortalization as a key, rate-limiting event in malignant transformation: approaches toward a molecular genetic analysis

1993 • 19 citations