Matrix metalloproteinases in skin

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

AP-1 function and regulation

1997 • 2,833 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

Molecular basis of sun-induced premature skin ageing and retinoid antagonism

1996 • 1,379 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.

1996 • 940 citations

Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules

1997 • 926 citations

Matrix Metalloproteinase-2 Is an Interstitial Collagenase

1995 • 917 citations

Biochemical Characterization of Human Collagenase-3

1996 • 871 citations

Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas

1994 • 769 citations

Wound Fluid from Chronic Leg Ulcers Contains Elevated Levels of Metalloproteinases MMP-2 and MMP-9

1993 • 728 citations

Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy

1994 • 660 citations

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

1995 • 620 citations

Molecular Cloning and Characterization of Human Tissue Inhibitor of Metalloproteinase 4

1996 • 547 citations

Macrophage-Derived Metalloelastase Is Responsible for the Generation of Angiostatin in Lewis Lung Carcinoma

1997 • 537 citations

Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs

1991 • 522 citations

Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.

1995 • 511 citations

The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis.

1996 • 491 citations

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

1994 • 485 citations

Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.

1993 • 479 citations

Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes

1987 • 474 citations

Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP)

1991 • 454 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

The Family of Matrix Metalloproteinases^a

1994 • 437 citations

Cytokine regulation of metalloproteinase gene expression

1993 • 432 citations

Role of the alpha v beta 3 integrin in human melanoma cell invasion.

1992 • 414 citations

Expression of matrix metalloproteinase-2 and -9 during early human wound healing.

1994 • 411 citations

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.

1990 • 406 citations

UVA irradiation induces collagenase in human dermal fibroblasts in vitro and in vivo

1991 • 392 citations

Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.

1990 • 379 citations

Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

1990 • 377 citations

Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.

1996 • 359 citations

The Role of the C-terminal Domain of Human Collagenase-3 (MMP-13) in the Activation of Procollagenase-3, Substrate Specificity, and Tissue Inhibitor of Metalloproteinase Interaction

1997 • 345 citations

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.

1992 • 331 citations

Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells.

1987 • 323 citations

Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing.

1993 • 319 citations

Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption.

1995 • 312 citations

The Gene Structure of Tissue Inhibitor of Metalloproteinases (TIMP)-3 and Its Inhibitory Activities Define the Distinct TIMP Gene Family

1995 • 295 citations

Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development

1997 • 292 citations

Distinct Populations of Stromal Cells Express Collagenase-3 (MMP-13) and Collagenase-1 (MMP-1) in Chronic Ulcers but Not in Normally Healing Wounds

1997 • 289 citations

Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview

1997 • 281 citations

A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling.

1995 • 280 citations

Tissue Inhibitor of Metalloproteinases-1 Is Decreased and Activated Gelatinases Are Increased in Chronic Wounds

1995 • 273 citations

Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells.

1998 • 268 citations

Identification and Characterization of a Novel Human Matrix Metalloproteinase with Unique Structural Characteristics, Chromosomal Location, and Tissue Distribution

1997 • 254 citations

Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck.

1997 • 247 citations

Structure and expression of the human gene for the matrix metalloproteinase matrilysin.

1994 • 243 citations

c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans.

1992 • 242 citations

Matrix Metalloproteinases, Gelatinase and Collagenase, in Chronic Leg Ulcers

1996 • 239 citations

Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds.

1994 • 238 citations

Gelatinase B–deficient Mice Are Resistant to Experimental Bullous Pemphigoid

1998 • 236 citations

Inhibition of Angiogenesis and Murine Hemangioma Growth by Batimastat, a Synthetic Inhibitor of Matrix Metalloproteinases

1995 • 234 citations

Enhanced Elastin and Fibrillin Gene Expression in Chronically Photodamaged Skin

1994 • 233 citations

Cloning of the cDNA Encoding Human Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) and Mapping of the TIMP3 Gene to Chromosome 22

1994 • 214 citations

92-kD gelatinase is produced by eosinophils at the site of blister formation in bullous pemphigoid and cleaves the extracellular domain of recombinant 180-kD bullous pemphigoid autoantigen.

1994 • 211 citations

Expression of collagenase‐related metalloproteinase genes in human lung or head and neck tumours

1991 • 210 citations

Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression.

1993 • 209 citations

Enhancement of Fibroblast Collagenase (Matrix Metalloproteinase-1)Gene Expression by Ceramide Is Mediated by Extracellular Signal-regulated and Stress-activated Protein Kinase Pathways

1998 • 209 citations

Long-term sun exposure alters the collagen of thepapillary dermis

1996 • 208 citations

Gelatinase A activity directly modulates melanoma cell adhesion and spreading.

1995 • 199 citations

Integrin expression in human melanoma cells with differing invasive and metastatic properties

1992 • 197 citations

Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94).

1996 • 195 citations

Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds.

1996 • 191 citations

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

1995 • 188 citations

Regulation of Membrane‐Type Matrix Metalloproteinase‐1 Expression by Growth Factors and Phorbol 12‐Myristate 13‐Acetate

1996 • 184 citations

Direct contact between T lymphocytes and monocytes is a major pathway for induction of metalloproteinase expression.

1994 • 180 citations

Human Collagenase-3 Is Expressed in Malignant Squamous Epithelium of the Skin

1997 • 179 citations

Gelatinase activity during wound healing

1994 • 177 citations

Cytokine Control of Interstitial Collagenase and Collagenase-3 Gene Expression in Human Chondrocytes

1996 • 176 citations

Matrix Metalloproteinase Matrilysin Is Constitutively Expressed in Adult Human Exocrine Epithelium

1995 • 174 citations

Distinct localization of collagenase and tissue inhibitor of metalloproteinases expression in wound healing associated with ulcerative pyogenic granuloma.

1992 • 167 citations

QUANTITATION AND IMMUNOCYTOCHEMICAL LOCALIZATION OF HUMAN SKIN COLLAGENASE IN BASAL CELL CARCINOMA

1977 • 166 citations

Human Macrophage Metalloelastase. GENOMIC ORGANIZATION, CHROMOSOMAL LOCATION, GENE LINKAGE, AND TISSUE-SPECIFIC EXPRESSION

1995 • 156 citations

Myofibroblasts from Scleroderma Skin Synthesize Elevated Levels of Collagen and Tissue Inhibitor of Metalloproteinase (TIMP-1) with Two Forms of TIMP-1

1995 • 153 citations

Tissue inhibitor of metalloproteinases-3 is a component of Bruch's membrane of the eye.

1997 • 151 citations

Human Skin Collagenase: Relationship to the Pathogenesis of Epidermolysis Bullosa Dystrophica*

1969 • 148 citations

The 72 kDa type IV collagenase is modulated via differential expression of alpha v beta 3 and alpha 5 beta 1 integrins during human melanoma cell invasion.

1993 • 147 citations

MATRIX METALLOPROTEINASE-2 (72 kD TYPE IV COLLAGENASE) EXPRESSION OCCURS IN THE EARLY STAGE OF HUMAN MELANOCYTIC TUMOUR PROGRESSION AND MAY HAVE PROGNOSTIC VALUE

1996 • 146 citations

Differential regulation of interstitial collagenase (MMP-1) gene expression by ETS transcription factors

1997 • 144 citations

Ultraviolet B irradiation promotes tumorigenic and metastatic properties in primary cutaneous melanoma via induction of interleukin 8.

1995 • 144 citations

Doxycycline and Chemically Modified Tetracyclines Inhibit Gelatinase A (MMP‐2) Gene Expression in Human Skin Keratinocytes

1994 • 141 citations

Suppression of Invasion by Inducible Expression of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) in B 16-F10 Melanoma Cells

1992 • 137 citations

Collagenase Expression Is Rapidly Induced in Wound-Edge Keratinocytes After Acute Injury in Human Skin, Persists During Healing, and Stops at Re-Epithelialization

1995 • 136 citations

Expression of gelatinase A and TIMP-2 mRNAs in desmoplastic fibroblasts in both mammary carcinomas and basal cell carcinomas of the skin.

1993 • 136 citations

A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence.

1994 • 135 citations

Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP‐3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10

1994 • 135 citations

Proteolytic activation of the precursor of membrane type 1 matrix metalloproteinase by human plasmin

1997 • 134 citations

Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters.

1995 • 128 citations

Breast-Cancer-Associated Stromelysin-3 Gene Is Expressed in Basal Cell Carcinoma and During Cutaneous Wound Healing

1992 • 127 citations

Role and regulation of expression of 92‐kDa type‐IV collagenase (MMP‐9) in 2 invasive squamous‐cell‐carcinoma cell lines of the oral cavity

1993 • 123 citations

Expression of the stromelysin-3 gene in fibroblastic cells of invasive carcinomas of the breast and other human tissues: a review

1993 • 123 citations

Identification of MMP-18, a Putative Novel Human Matrix Metalloproteinase

1996 • 123 citations

Decreased Collagenase Expression in Cultured Systemic Sclerosis Fibroblasts

1994 • 119 citations

Cloning of collagenase 3 from the synovial membrane and its expression in rheumatoid arthritis and osteoarthritis.

1996 • 119 citations

Biology of tumor cell invasion: Interplay of cell adhesion and matrix degradation

1996 • 113 citations

A polyomavirus enhancer A-binding protein-3 site and Ets-2 protein have a major role in the 12-O-tetradecanoylphorbol-13-acetate response of the human stromelysin gene.

1993 • 112 citations

92-kd gelatinase is actively expressed by eosinophils and stored by neutrophils in squamous cell carcinoma.

1993 • 110 citations

Demonstration of 72-kDa and 92-kDa Forms of Type IV Collagenase in Human Skin: Variable Expression in Various Blistering Diseases, Induction During Re-Epithelialization, and Decrease by Topical Glucocorticoids

1993 • 106 citations

Melanoma-mediated dissolution of extracellular matrix: contribution of urokinase-dependent and metalloproteinase-dependent proteolytic pathways.

1993 • 106 citations

Experimental and clinical studies on the use of matrix metalloproteinase inhibitors for the treatment of cancer

1996 • 106 citations

Expression of c-ets-1, collagenase 1, and urokinase-type plasminogen activator genes in lung carcinomas.

1995 • 101 citations

Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters

1993 • 97 citations

Localization of mRNAs representing collagenase and TIMP in sections of healing human burn wounds.

1993 • 95 citations

Collagen-stimulated induction of keratinocyte collagenase is mediated via tyrosine kinase and protein kinase C activities.

1994 • 94 citations

Interstitial collagenase gene expression in oral squamous cell carcinoma.

1992 • 90 citations

Detection of mRNAs encoding collagenase I and stromelysin 2 in carcinomas of the head and neck by in situ hybridization.

1991 • 88 citations

Ultraviolet Radiation Activates the Human Elastin Promoter in Transgenic Mice: A Novel In Vivo and In Vitro Model Of Cutaneous Photoaging

1995 • 87 citations

Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta.

1997 • 83 citations

Interstitial Collagenase Is Expressed by Keratinocytes That Are Actively Involved in Reepithelialization in Blistering Skin Diseases

1995 • 81 citations

Expression of matrix metalloproteinase-3 in stage I and II squamous cell carcinoma of the oral cavity

1995 • 81 citations

Matrilysin (PUMP) Correlates with Dermal Invasion During Appendageal Development and Cutaneous Neoplasia

1994 • 78 citations

Serum tissue inhibitor of metalloproteinases in patients with systemic sclerosis

1995 • 76 citations

Localization by In Situ Hybridization of mRNAs Encoding Stromelysin 3 and Tissue Inhibitors of Metallo-Proteinases TIMP-1 and TIMP-2 in Human Head and Neck Carcinomas*

1993 • 75 citations

Expression of 92-kDa Type IV Collagenase mRNA by Eosinophils Associated with Basal Cell Carcinoma

1992 • 67 citations

Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds

1996 • 67 citations

Activation of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) mRNA Expression in Scleroderma Skin Fibroblasts

1998 • 67 citations

On the structure and chromosome location of the 72- and 92-kDa human type IV collagenase genes

1991 • 66 citations

Localization of 92-kDa Type IV Collagenase in Human Skin Tumors: Comparison with Normal Human Fetal and Adult Skin

1993 • 64 citations

Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines.

1996 • 63 citations

Expression of Interstitial Collagenase, 92-kDa Gelatinase, and Tissue Inhibitor of Metalloproteinases-1 in Granuloma Annulare and Necrobiosis Lipoidica Diabeticorum

1993 • 62 citations

Excess matrix accumulation in scleroderma is caused partly by differential regulation of stromelysin and TIMP-1 synthesis

1994 • 62 citations

Selective endothelial growth inhibition by tetracyclines that inhibit collagenase

1992 • 60 citations

Modulation of M_r 72,000 and M_r 92,000 type‐IV collagenase (gelatinase A and B) gene expression by interferons alpha and gamma in human melanoma

1994 • 58 citations

Immunocytochemical Localization of Collagenase in Human Skin and Fibroblasts in Monolayer Culture

1974 • 57 citations

Human TIMP-3 Is Expressed During Fetal Development, Hair Growth Cycle, and Cancer Progression

1998 • 56 citations

Transcriptional downregulation of stromelysin by tetracycline

1996 • 54 citations

Stromelysin-3 mRNA Associated with Myofibroblasts Is Overexpressed in Aggressive Basal Cell Carcinoma and in Dermatofibroma but Not in Dermatofibrosarcoma

1996 • 53 citations

Activation of Dermal Connective Tissue in Scleroderma

1993 • 53 citations

What's in a Name? The American Society for Investigative Pathology.

1993 • 53 citations

Uncoordinate regulation of collagenase, stromelysin, and tissue inhibitor of metalloproteinases genes by prostaglandin E₂: Selective enhancement of collagenase gene expression in human dermal fibroblasts in culture

1994 • 53 citations

The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family

1995 • 50 citations

Altered expression of basement membrane proteins and their integrin receptors in lichen planus: possible pathogenetic role of gelatinases A and B.

1996 • 48 citations

Increased expression of stromelysin‐3 in basal cell carcinomas

1994 • 46 citations

Collagenase Production at the Border of Granulation Tissue in a Healing Wound: Macrophage and Mesenchymal Collagenase Productionin Vivo

1991 • 46 citations

Immunolocalization of collagenase and tissue inhibitor of metalloproteinases (TIMP) in hypertrophic scar tissue

1986 • 38 citations

Elevated Levels of Human Collagenase Inhibitor in Blister Fluids of Diverse Etiology

1986 • 36 citations

Urokinase Plasminogen Activator Is Expressed By Basal Keratinocytes Before Interstitial Collagenase, Stromelysin-1, and Laminin-5 in Experimentally Induced Dermatitis Herpetiformis Lesions

1997 • 36 citations

Enhanced Expression of Interstitial Collagenase, Stromelysin-1, and Urokinase Plasminogen Activator in Lesions of Dermatitis Herpetiformis

1995 • 35 citations

Immunolocalizations of human gelatinase (type IV collagenase, MMP-9) and TIMP (tissue inhibitor of metalloproteinases) in normal epidermis and some epidermal tumors

1996 • 34 citations

Destruction of the Epithelial Anchoring System in Lichen Planus

1995 • 32 citations

Collagenase Expression in Skin Fibroblasts from Families with Recessive Dystrophic Epidermolysis Bullosa

1989 • 31 citations

Lysis of type‐i collagen by squamous carcinomas of the head and neck

1985 • 30 citations

Expression of Stromelysin 3 in the Stromal Elements of Human Basal Cell Carcinoma

1992 • 30 citations

Genes of the Membrane-Type Matrix Metalloproteinase (MT-MMP) Gene Family, MMP14, MMP15, and MMP16, Localize to Human Chromosomes 14, 16, and 8, Respectively

1997 • 29 citations

Differential Expression of Tissue Inhibitor of Metalloproteinases-2 by Cutaneous Squamous and Basal Cell Carcinomas

1996 • 28 citations

Increased gene expression of matrix metalloproteinase-3 (stromelysin) in skin fibroblasts from patients with severe recessive dystrophic epidermolysis bullosa

1991 • 27 citations

The Role of Proteases in the Pathogenesis of Bullous Dermatoses

1988 • 26 citations

Anchoring Fibrils, Collagen VII, and Neutral Metalloproteases in Recessive Dystrophic Epidermolysis Bullosa Inversa

1992 • 23 citations

Localization of Type I Human Skin Collagenase in Developing Embryonic and Fetal Skin

1994 • 22 citations

Expression of 72 kilodalton and 92 kilodalton type IV collagenase in malignant fibrous histiocytomas and dermatofibromas.

1993 • 15 citations

Expression of the tissue metalloproteinase inhibitors TIMP-1 and TIMP-2 in malignant fibrous histiocytomas and dermatofibromas as studied by in situ hybridization and immunohistochemistry*1

1996 • 13 citations

Role of prolactin in growth of the rat mammary tumor MTW9

1991 • 4 citations