Osteoclastic Bone Degradation and the Role of Different Cysteine Proteinases and Matrix Metalloproteinases: Differences Between Calvaria and Long Bone

Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency

1996 • 1,003 citations

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

1998 • 900 citations

Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

2000 • 553 citations

Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization

1999 • 491 citations

Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts

1996 • 427 citations

The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation

2002 • 389 citations

Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities

2003 • 331 citations

Regulation of the differentiation and function of osteoclasts

2000 • 308 citations

Cathepsin L deficiency as molecular defect offurless:hyperproliferation of keratinocytes and pertubation of hair follicle cycling

2000 • 302 citations

Degradation of collagen in the bone‐resorbing compartment underlying the osteoclast involves both cysteine‐proteinases and matrix metalloproteinases

1992 • 286 citations

Human Cathepsin O2, a Novel Cysteine Protease Highly Expressed in Osteoclastomas and Ovary Molecular Cloning, Sequencing and Tissue Distribution

1995 • 241 citations

CA074 methyl ester: A proinhibitor for intracellular cathepsin B

1992 • 200 citations

Functional heterogeneity of osteoclasts: matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone

1999 • 168 citations

Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio

2004 • 167 citations

The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts

1994 • 167 citations

Cathepsin K Antisense Oligodeoxynucleotide Inhibits Osteoclastic Bone Resorption

1997 • 155 citations

Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate

2001 • 154 citations

Physiological mechanisms for metalloproteinase activation.

1992 • 142 citations

Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L

1996 • 139 citations

Cysteine Proteinases and Matrix Metalloproteinases Play Distinct Roles in the Subosteoclastic Resorption Zone

1998 • 135 citations

Phagocytosis of bone collagen by osteoclasts in two cases of pycnodysostosis

1985 • 135 citations

A nonsense mutation in the cathepsin K gene observed in a family with pycnodysostosis.

1996 • 133 citations

Participation of cathepsin L on bone resorption

1993 • 130 citations

Novel, Nonpeptidic Cyanamides as Potent and Reversible Inhibitors of Human Cathepsins K and L

2000 • 127 citations

Localization of Rat Cathepsin K in Osteoclasts and Resorption Pits: Inhibition of Bone Resorption and Cathepsin K-Activity by Peptidyl Vinyl Sulfones

1999 • 126 citations

Inhibition of bone resrption by selctive inactivators of cysteine proteinases

1994 • 117 citations

Dimerization of Midkine by Tissue Transglutaminase and Its Functional Implication

1997 • 115 citations

Cathepsins in the osteoclast

2003 • 111 citations

Gelatinase A (MMP-2) and cysteine proteinases are essential for the degradation of collagen in soft connective tissue

1998 • 107 citations

Effects of the proteinase inhibitors leupeptin and E-64 on osteoclastic bone resorption

1988 • 97 citations

Degradation of the Organic Phase of Bone by Osteoclasts: A Secondary Role for Lysosomal Acidification

2006 • 95 citations

Cathepsin K Deficiency in Pycnodysostosis Results in Accumulation of Non-Digested Phagocytosed Collagen in Fibroblasts

2003 • 95 citations

Cathepsin B and L activities in isolated osteoclasts

1991 • 94 citations

Localization of cathepsins B, D, and L in the rat osteoclast by immuno-light and -electron microscopy

1994 • 83 citations

A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat

2002 • 79 citations

Immunohistochemical localization of cathepsins B, D and L in the rat osteoclast

1993 • 77 citations

Cathepsin L‐deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy

2004 • 71 citations

Substrate Specificity of Recombinant Osteoclast-Specific Cathepsin K from Rabbits.

1996 • 53 citations

Azapeptides Structurally Based upon Inhibitory Sites of Cystatins as Potent and Selective Inhibitors of Cysteine Proteases

2002 • 46 citations

An ultrastructural evaluation of the effects of cysteine-proteinase inhibitors on osteoclastic resorptive functions

1995 • 39 citations

The relative contribution of cysteine proteinases and matrix metalloproteinases to the resorption process in osteoclasts derived from long bone and scapula

2004 • 39 citations

Different Cysteine Proteinases Involved in Bone Resorption and Osteoclast Formation

2005 • 38 citations

Potent and Selective Cathepsin L Inhibitors Do Not Inhibit Human Osteoclast Resorption in Vitro

2001 • 33 citations

The Regulation of Bone Resorption in Tooth Formation and Eruption Processes in Mouse Alveolar Crest Devoid of Cathepsin K

2003 • 23 citations

Immunocytochemical study of cathepsin L and rat salivary cystatin-3 in rat osteoclasts treated with E-64 in vivo

1997 • 16 citations

Matrix Metalloproteinase Inhibitors Block Osteoclastic Resorption of Calvarial Bone but not the Resorption of Long Bone

1999 • 14 citations

Low molecular weight inhibitors of matrix metalloproteinases can enhance the expression of matrix metalloproteinase‐2 (gelatinase A) without inhibiting its activation

2003 • 12 citations