Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

How Matrix Metalloproteinases Regulate Cell Behavior

2001 • 3,860 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

1998 • 1,753 citations

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

1999 • 1,280 citations

Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency

1996 • 1,003 citations

Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis

1996 • 997 citations

Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules

1997 • 926 citations

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

1998 • 900 citations

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

2000 • 792 citations

Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration

2001 • 732 citations

The Use of Biochemical Markers of Bone Turnover in Osteoporosis

2000 • 714 citations

Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts

1996 • 706 citations

Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion

1999 • 699 citations

The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases

1998 • 631 citations

Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones

2000 • 589 citations

Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.

1996 • 496 citations

Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization

1999 • 491 citations

A New Member of Tumor Necrosis Factor Ligand Family, ODF/OPGL/TRANCE/RANKL, Regulates Osteoclast Differentiation and Function

1999 • 464 citations

The Type I Collagen Fragments ICTP and CTX Reveal Distinct Enzymatic Pathways of Bone Collagen Degradation

2003 • 450 citations

Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice

1999 • 408 citations

Proteolysis of Latent Transforming Growth Factor-β (TGF-β)-binding Protein-1 by Osteoclasts

2002 • 403 citations

The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation

2002 • 389 citations

Generation and degradation of human endostatin proteins by various proteinases

2000 • 379 citations

Matrix metalloproteinases and TIMPs

2000 • 379 citations

Degradation of Interleukin 1β by Matrix Metalloproteinases

1996 • 374 citations

Unaltered Secretion of β-Amyloid Precursor Protein in Gelatinase A (Matrix Metalloproteinase 2)-deficient Mice

1997 • 352 citations

Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts.

1994 • 340 citations

Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structures.

1984 • 324 citations

Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption.

1995 • 312 citations

Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome

2001 • 305 citations

Biology and Physiology of the Osteoclast

1992 • 297 citations

Degradation of collagen in the bone‐resorbing compartment underlying the osteoclast involves both cysteine‐proteinases and matrix metalloproteinases

1992 • 286 citations

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor.

1995 • 254 citations

Initiation of Osteoclast Bone Resorption by Interstitial Collagenase

1997 • 250 citations

Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis.

1997 • 235 citations

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes.

1995 • 234 citations

In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption

1984 • 229 citations

Proteinases in bone resorption: obvious and less obvious roles

2000 • 222 citations

Matrix Metalloproteinase Activity, Bone Matrix Turnover, and Tumor Cell Proliferation in Prostate Cancer Bone Metastasis

2002 • 221 citations

Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones

1995 • 218 citations

Identification of the membrane-type matrix metalloproteinase MT1-MMP in osteoclasts

1997 • 213 citations

Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice

1999 • 213 citations

Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity

2002 • 213 citations

Processing of Integrin αv Subunit by Membrane Type 1 Matrix Metalloproteinase Stimulates Migration of Breast Carcinoma Cells on Vitronectin and Enhances Tyrosine Phosphorylation of Focal Adhesion Kinase

2002 • 212 citations

Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry

1997 • 194 citations

Bone Mineral Changes in Obese Women During a Moderate Weight Loss With and Without Calcium Supplementation

2001 • 194 citations

The effects of inhibitors of cysteine-proteinases and collagenase on the resorptive activity of isolated osteoclasts☆

1987 • 176 citations

Towards Specific Functions of Lysosomal Cysteine Peptidases: Phenotypes of Mice Deficient for Cathepsin B or Cathepsin L

2001 • 173 citations

Identification of matrix metalloproteinase 9 in rabbit osteoclasts.

1994 • 169 citations

Functional heterogeneity of osteoclasts: matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone

1999 • 168 citations

A Carboxyl-Terminal Peptide from the Parathyroid Hormone-Related Protein Inhibits Bone Resorption by Osteoclasts*

1991 • 168 citations

The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts

1994 • 167 citations

Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate

2001 • 154 citations

Serum concentration of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is a useful prognostic indicator in multiple myeloma

1992 • 154 citations

Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis

1999 • 151 citations

Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes.

1995 • 150 citations

Determination of Bone Markers in Pycnodysostosis: Effects of Cathepsin K Deficiency on Bone Matrix Degradation

1999 • 147 citations

Expression and induction of collagenases (MMP-8 and -13) in plasma cells associated with bone-destructive lesions

2001 • 144 citations

Accelerated Turnover of Metaphyseal Trabecular Bone in Mice Overexpressing Cathepsin K

2001 • 141 citations

(Pro)collagenase (matrix metalloproteinase-1) is present in rodent osteoclasts and in the underlying bone-resorbing compartment

1993 • 140 citations

Cysteine Proteinases and Matrix Metalloproteinases Play Distinct Roles in the Subosteoclastic Resorption Zone

1998 • 135 citations

Phagocytosis of bone collagen by osteoclasts in two cases of pycnodysostosis

1985 • 135 citations

Biochemical and Pharmacological Criteria Define Two Shedding Activities for TRANCE/OPGL That Are Distinct from the Tumor Necrosis Factor α Convertase

2001 • 133 citations

Adaptations of Goldner's Masson Trichrome Stain for the Study of Undecalcified Plastic Embedded Bone

1992 • 130 citations

Inhibition of bone resrption by selctive inactivators of cysteine proteinases

1994 • 117 citations

Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development

1996 • 114 citations

Estrogen Reduces the Depth of Resorption Pits by Disturbing the Organic Bone Matrix Degradation Activity of Mature Osteoclasts

2001 • 113 citations

Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase

2014 • 112 citations

Differential Patterns of Bone Turnover in Relation to Bone Pain and Disease Extent in Bone in Cancer Patients with Skeletal Metastases

1999 • 111 citations

Fluorescence Microscopic Demonstration of Cathepsin K Activity as the Major Lysosomal Cysteine Proteinase in Osteoclasts

1998 • 110 citations

ADAM8: A Novel Osteoclast Stimulating Factor

2001 • 106 citations

Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinases.

1994 • 106 citations

Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase

2001 • 105 citations

Proteolysis of human bone collagen by cathepsin K: characterization of the cleavage sites generating the cross-linked N-telopeptide neoepitope

2000 • 100 citations

The Migration of Purified Osteoclasts Through Collagen Is Inhibited by Matrix Metalloproteinase Inhibitors

1998 • 98 citations

Biochemical markers of bone metabolism reflect osteoclastic and osteoblastic activity in multiple myeloma

2000 • 98 citations

Expression of metalloproteinase-13 (collagenase-3) is induced during fracture healing in mice

1999 • 98 citations

A new synthetic inhibitor of mammalian tissue collagenase inhibits bone resorption in culture

1985 • 98 citations

Effects of the proteinase inhibitors leupeptin and E-64 on osteoclastic bone resorption

1988 • 97 citations

Type I collagen degradation product (ICTP) gives information about the nature of bone metastases and has prognostic value in prostate cancer

1995 • 95 citations

Localisation of mRNA for collagenase in osteocytic, bone surface and chondrocytic cells but not osteoclasts

1995 • 95 citations

Correlation Between Bone Metabolic Markers and Bone Scan in Prostatic Cancer

1997 • 90 citations

Localization of CD44, the hyaluronate receptor; on the plasma membrane of osteocytes and osteoclasts in rat tibiae

1995 • 85 citations

Transforming Growth Factor-β-induced Osteoblast Elongation Regulates Osteoclastic Bone Resorption through a p38 Mitogen-activated Protein Kinase- and Matrix Metalloproteinase-dependent Pathway

2001 • 81 citations

A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat

2002 • 79 citations

Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.

2002 • 69 citations

Perspectives: Osteoclast adhesion and resorption: The role of podosomes

1992 • 68 citations

Identification and Characterization of the Insulin-like Growth Factor I Receptor in Mature Rabbit Osteoclasts

1997 • 67 citations

Markers of type I collagen degradation and synthesis in the monitoring of treatment response in bone metastases from breast carcinoma

1996 • 65 citations

Collagenolytic Cathepsins of Rabbit Spleen: A Kinetic Analysis of Collagen Degradation and Inhibition by Chicken Cystatin

1987 • 59 citations

Production of collagenase by human osteoblasts and osteoclasts in vivo

1996 • 58 citations

Transforming Growth Factor-β Induces Osteoclast Ruffling and Chemotaxis: Potential Role in Osteoclast Recruitment

2001 • 57 citations

Bone resorption by isolated osteoclasts in living versus devitalized bone: Differences in mode and extent and the effects of human recombinant tissue inhibitor of metalloproteinases

1990 • 54 citations

Risk Factors for Vertebral Deformities in Men: Relationship to Number of Vertebral Deformities

2000 • 51 citations

Enzymes active in the areas undergoing cartilage resorption during the development of the secondary ossification center in the tibiae of rats ages 0–21 days: I. Two groups of proteinases cleave the core protein of aggrecan

2001 • 50 citations

Localisation of matrix metalloproteinases and TIMP-2 in resorbing mouse bone

2000 • 50 citations

Active gelatinase B is identified by histozymography in the cartilage resorption sites of developing long bones

1999 • 47 citations

Localisation of matrix metalloproteinases and TIMP-2 in resorbing mouse bone

2000 • 44 citations

Cellular Localization of Neprilysin in Mouse Bone Tissue and Putative Role in Hydrolysis of Osteogenic Peptides

2000 • 41 citations

Biology of the Osteoclast

1993 • 35 citations

Immunohistochemical localization of membrane type 1-matrix metalloproteinase (MT1-MMP) in osteoclasts in vivo

2001 • 33 citations

Potent and Selective Cathepsin L Inhibitors Do Not Inhibit Human Osteoclast Resorption in Vitro

2001 • 33 citations

A selective inhibitor of matrix metalloproteinases inhibits the migration of isolated osteoclasts by increasing the life span of podosomes

2002 • 30 citations

Autodegradation of lysosomal cysteine proteinases

1987 • 30 citations

Distinct Roles of Cathepsin K and Cathepsin L IN Osteoclastic Bone Resorption

2000 • 27 citations

Immunolocalization of matrix metalloproteinases and their inhibitors in clinical specimens of bone metastasis from breast carcinoma.

2000 • 24 citations

Increased activities of cathepsin B and other lysosomal hydrolases in fibroblasts and bone tissue cultured in the presence of cysteine proteinases inhibitors

1994 • 24 citations

Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR

2001 • 22 citations

Spatiotemporal change of rat collagenase (MMP-13) mRNA expression in the development of the rat femoral neck

2000 • 22 citations