Bortezomib inhibits human osteoclastogenesis
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References (52)
Osteoclast differentiation and activation
2003 • 6,172 citations
Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density
1997 • 5,058 citations
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
1998 • 4,184 citations
Bone Resorption by Osteoclasts
2000 • 3,797 citations
Metastasis to bone: causes, consequences and therapeutic opportunities
2002 • 2,661 citations
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
1997 • 2,257 citations
Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families
1999 • 2,238 citations
IκB: a Specific Inhibitor of the NF-κB Transcription Factor
1988 • 2,203 citations
The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
1994 • 2,124 citations
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
1999 • 1,621 citations
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.
2001 • 1,520 citations
Proteasome inhibitors: a novel class of potent and effective antitumor agents.
1999 • 1,447 citations
The IKK NF-κB system: a treasure trove for drug development
2004 • 1,340 citations
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
1999 • 1,267 citations
c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling
1994 • 1,253 citations
Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesisin Vitro1
1998 • 1,211 citations
TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells
1997 • 1,054 citations
NF-κB as a Therapeutic Target in Multiple Myeloma
2002 • 906 citations
Stimulation of Osteoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in Human Osteoblastic Lineage Cells: Potential Paracrine Mechanisms of Glucocorticoid-Induced Osteoporosis1
1999 • 779 citations
RANK Is the Essential Signaling Receptor for Osteoclast Differentiation Factor in Osteoclastogenesis
1998 • 729 citations
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.
1994 • 723 citations
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
2003 • 572 citations
Involvement of p38 Mitogen-activated Protein Kinase Signaling Pathway in Osteoclastogenesis Mediated by Receptor Activator of NF-κB Ligand (RANKL)
2000 • 511 citations
Identity of the 19S 'prosome' particle with the large multifunctional protease complex of mammalian cells (the proteasome)
1988 • 404 citations
Degradation of nuclear oncoproteins by the ubiquitin system in vitro.
1991 • 345 citations
Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts
2000 • 345 citations
The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications
2004 • 335 citations
The Mouse Gene for Vascular Endothelial Growth Factor
1996 • 335 citations
Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion
2004 • 319 citations
Fracture Risk With Multiple Myeloma: A Population-Based Study
2005 • 312 citations
Multiple myeloma bone disease: pathophysiology of osteoblast inhibition
2006 • 299 citations
RANK ligand and osteoprotegerin in myeloma bone disease
2003 • 260 citations
Bortezomib reduces serum dickkopf‐1 and receptor activator of nuclear factor‐κB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma
2006 • 218 citations
Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo.
2003 • 216 citations
Dual effects of macrophage inflammatory protein-1α on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease
2003 • 214 citations
Receptor activator of nuclear factor-κB ligand and osteoprotegerin
2001 • 191 citations
Cancer and the Microenvironment
2004 • 188 citations
Degradation of the Proto-Oncogene Product c-Fos by the Ubiquitin Proteolytic System In Vivo and In Vitro: Identification and Characterization of the Conjugating Enzymes
1995 • 167 citations
JunB can substitute for Jun in mouse development and cell proliferation
2002 • 156 citations
Expression of receptor activator of nuclear factor kappaB ligand on bone marrow plasma cells correlates with osteolytic bone disease in patients with multiple myeloma.
2003 • 156 citations
Expression of VEGF and its receptors by myeloma cells
2003 • 146 citations
The IκB Kinase Complex and NF-κB Actas Master Regulators of Lipopolysaccharide-Induced Gene Expressionand Control Subordinate Activation ofAP-1
2004 • 145 citations
Proteasome inhibitor PS‐341 induces growth arrest and apoptosis of non‐small cell lung cancer cells via the JNK/c‐Jun/AP‐1 signaling
2004 • 133 citations
Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma
2006 • 128 citations
p38 Mitogen-Activated Protein Kinase Is Crucially Involved in Osteoclast Differentiation But Not in Cytokine Production, Phagocytosis, or Dendritic Cell Differentiation of Bone Marrow Macrophages
2003 • 87 citations
RANKing c-Jun in osteoclast development
2004 • 82 citations
Biologic sequelae of c-Jun NH2-terminal kinase (JNK) activation in multiple myeloma cell lines
2003 • 76 citations
Novel aspects of osteoclast activation and osteoblast inhibition in myeloma bone disease
2005 • 72 citations
Proteasome as an Emerging Therapeutic Target in Cancer
2007 • 64 citations
New insights into the pathophysiology and management of bone disease in multiple myeloma
2003 • 57 citations
Regulation of c-Jun Phosphorylation by the IκB Kinase-ε Complex in Fibroblast-Like Synoviocytes
2005 • 49 citations
Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system
1992 • 26 citations