Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation
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References (64)
Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation
1998 • 5,369 citations
Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation
2002 • 3,503 citations
Multiple myeloma
2000 • 2,210 citations
A PROSPECTIVE, RANDOMIZED TRIAL OF AUTOLOGOUS BONE MARROW TRANSPLANTATION AND CHEMOTHERAPY IN MULTIPLE MYELOMA
2013 • 2,176 citations
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.
2001 • 1,520 citations
The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma
2003 • 1,491 citations
Efficacy of Pamidronate in Reducing Skeletal Events in Patients with Advanced Multiple Myeloma
1996 • 1,091 citations
Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton
2003 • 869 citations
Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines
1999 • 850 citations
Multiple myeloma: evolving genetic events and host interactions
2002 • 815 citations
Wnt signaling in osteoblasts and bone diseases
2004 • 794 citations
Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6
1989 • 775 citations
Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process
1998 • 761 citations
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.
1996 • 650 citations
Advances in biology of multiple myeloma: clinical applications
2004 • 606 citations
Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B
1996 • 582 citations
Superiority of Tandem Autologous Transplantation Over Standard Therapy for Previously Untreated Multiple Myeloma
1997 • 576 citations
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications
2001 • 562 citations
Adhesion mechanisms regulating the migration of monocytes
2004 • 552 citations
Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
2001 • 525 citations
Involvement of p38 Mitogen-activated Protein Kinase Signaling Pathway in Osteoclastogenesis Mediated by Receptor Activator of NF-κB Ligand (RANKL)
2000 • 511 citations
Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias.
1989 • 501 citations
IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release.
1990 • 493 citations
Map kinase signaling pathways and hematologic malignancies
2003 • 433 citations
Molecular mechanisms of novel therapeutic approaches for multiple myeloma
2002 • 431 citations
Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
2001 • 420 citations
Regulation of Osteoclast Function
1997 • 411 citations
The role of tumor necrosis factor α in the pathophysiology of human multiple myeloma: therapeutic applications
2001 • 398 citations
Allogeneic Bone Marrow Transplantation in Multiple Myeloma
1991 • 389 citations
Macrophage inflammatory protein-1α is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor κB ligand
2001 • 330 citations
Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation
2005 • 318 citations
Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity
2002 • 309 citations
The phosphatidylinositol 3-Kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation
2002 • 303 citations
B-Type Natriuretic Peptide Exerts Broad Functional Opposition to Transforming Growth Factor-β in Primary Human Cardiac Fibroblasts
2004 • 296 citations
Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma
2002 • 289 citations
Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma
1995 • 275 citations
Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27
1995 • 264 citations
Mechanisms of bone destruction in multiple myeloma: the importance of an unbalanced process in determining the severity of lytic bone disease.
1989 • 240 citations
Role of the tumor microenvironment in mediating de novo resistance to drugs and physiological mediators of cell death
2003 • 202 citations
Cancer and the Microenvironment
2004 • 188 citations
Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma
2003 • 169 citations
New insights into role of microenvironment in multiple myeloma
2000 • 153 citations
MIP-1α utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells
2005 • 148 citations
Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters
1991 • 139 citations
p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells
2004 • 133 citations
IL-6 Mediates the Effects of IL-1 or TNF, but Not PTHrP or 1,25(OH)2D3, on Osteoclast-like Cell Formation in Normal Human Bone Marrow Cultures
1998 • 124 citations
Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu
2002 • 120 citations
Anti‐myeloma activity of pamidronate in vivo
1998 • 109 citations
TNF-related apoptosis-inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL plus M-CSF
2004 • 108 citations
TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release
2005 • 104 citations
Cytokine, cytokine receptors, transduction signals, and oncogenes in human multiple myeloma.
1995 • 103 citations
Expression of interleukin‐1β and tumour necrosis factor‐α in plasma cells from patients with multiple myeloma
1999 • 95 citations
Advances in Biology and Therapy of Multiple Myeloma
2003 • 93 citations
The tumor microenvironment: focus on myeloma
2003 • 89 citations
The tumor microenvironment as a determinant of drug response and resistance
1999 • 86 citations
GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment
2003 • 84 citations
High-dose busulfan and cyclophosphamide are an effective conditioning regimen for allogeneic bone marrow transplantation in chemosensitive multiple myeloma
1998 • 65 citations
PATHOGENESIS AND MANAGEMENT OF BONE LESIONS IN MULTIPLE MYELOMA
1997 • 65 citations
Multiple Myeloma
2002 • 60 citations
Cytokines (IL-6, TNF-alpha, IL-1alpha) and soluble interleukin-2 receptor as serum tumor markers in multiple myeloma.
1996 • 55 citations
The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic acid on multiple myeloma cells
2002 • 50 citations
Drug resistance and drug development in multiple myeloma
2002 • 32 citations
Drug resistance and drug development in multiple myeloma
2002 • 29 citations
Bisphosphonate Induced Growth Inhibition of Breast Cancer Cells is Augmented by p38 Inhibition
2003 • 28 citations