Mechanism and regulation of protein degradation in liver

Functions of Lysosomes

1966 • 2,942 citations

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

Protein turnover in mammalian tissues and in the whole body

1978 • 1,237 citations

Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.

1975 • 916 citations

Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study.

1977 • 827 citations

CYTOPLASMIC COMPONENTS IN HEPATIC CELL LYSOSOMES

1962 • 803 citations

Leucine. A possible regulator of protein turnover in muscle.

1975 • 746 citations

PROTEIN DEGRADATION IN CULTURED CELLS

1974 • 603 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

Observations on the Cytology and Electron Microscopy of Hepatic Cells<xref ref-type="fn" rid="fn1">1</xref>, <xref ref-type="fn" rid="fn2">2</xref>

1955 • 456 citations

Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle?

1982 • 445 citations

Intracellular Protein Catabolism and its Control During Nutrient Deprivation and Supply

1987 • 437 citations

The diurnal response of muscle and liver protein synthesis in vivo in meal-fed rats

1973 • 426 citations

Ntau-methylhistidine (3-methylhistidine) and muscle protein turnover: an overview.

1978 • 392 citations

The effect of starvation on the rate of protein synthesis in rat liver and small intestine

1979 • 391 citations

Inhibition by Insulin of Valine Turnover in Liver

1970 • 338 citations

Induction of autophagy by amino-acid deprivation in perfused rat liver

1977 • 323 citations

The effect of protein deprivation and starvation on the rate of protein synthesis in tissues of the rat

1975 • 287 citations

Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy.

1978 • 276 citations

Molecular determinants of protein half‐lives in eukaryotic cells

1987 • 268 citations

Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells

1976 • 234 citations

Compartmentation of Free Valine and Its Relation to Protein Turnover in Perfused Rat Liver

1972 • 231 citations

Glucagon-induced autophagy and proteolysis in rat liver: mediation by selective deprivation of intracellular amino acids.

1979 • 231 citations

Quantitative relationship between autophagy and proteolysis during graded amino acid deprivation in perfused rat liver.

1981 • 223 citations

The ubiquitin‐mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation

1984 • 221 citations

Inhibition of protein degradation in isolated rat hepatocytes

1977 • 214 citations

THE QUANTITIES OF PROTEIN LOST BY THE VARIOUS ORGANS AND TISSUES OF THE BODY DURING A FAST

1936 • 214 citations

Mechanisms of Intralysosomal Degradation with Special Reference to Autophagocytosis and Heterophagocytosis of Cell Organelles

1981 • 197 citations

Protein Degradation in Cultured Cells

1973 • 195 citations

Assessment of protein turnover in perfused rat liver. Evidence for amino acid compartmentation from differential labeling of free and tRNA-gound valine.

1976 • 192 citations

Suppression of Protein Turnover by Amino Acids in the Perfused Rat Liver

1972 • 190 citations

Compartmentation of free amino acids for protein synthesis in rat liver

1974 • 180 citations

Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes

1980 • 172 citations

Quantitative correlation between proteolysis and macro- and microautophagy in mouse hepatocytes during starvation and refeeding.

1983 • 171 citations

The effect of protease inhibitors and decreased temperature on the degradation of different classes of proteins in cultured hepatocytes

1979 • 157 citations

Alanine and glutamine synthesis and release from skeletal muscle. IV. beta-Adrenergic inhibition of amino acid release.

1976 • 151 citations

Amino acid control of autophagic sequestration and protein degradation in isolated rat hepatocytes.

1984 • 150 citations

Regulation of microautophagy and basal protein turnover in rat liver. Effects of short-term starvation.

1988 • 149 citations

Blood and tissue branched-chain amino and α-keto acid concentrations: effect of diet, starvation, and disease

1981 • 145 citations

Multifunctional control of amino acids of deprivation-induced proteolysis in liver. Role of leucine.

1982 • 139 citations

Effect of nutrition on protein turnover in skeletal muscle.

1978 • 133 citations

Sequestration of cytoplasmic enzymes in an autophagic vacuole-lysosomal system induced by injection of leupeptin.

1983 • 128 citations

Requirement for protein synthesis in the regulation of protein breakdown in cultured hepatoma cells

1975 • 125 citations

Regulation of catabolism of microinjected ribonuclease A. Identification of residues 7-11 as the essential pentapeptide.

1986 • 117 citations

Differential effects of proteinase inhibitors and amines on the lysosomal and non-lysosomal pathways of protein degradation in isolated rat hepatocytes

1980 • 114 citations

Effects of Glucagon on General Protein Degradation and Synthesis in Perfused Rat Liver

1974 • 111 citations

Specificity of the effects of leucine and its metabolites on protein degradation in skeletal muscle

1984 • 107 citations

Alterations of lysosomal size and density during rat liver perfusion. Suppression by insulin and amino acids.

1977 • 106 citations

Degradation of short and long lived proteins in isolated rat liver lysosomes. Effects of pH, temperature, and proteolytic inhibitors.

1985 • 105 citations

Protein metabolism in skeletal muscle: the effect of feeding and fasting on muscle RNA, free amino acids and plasma insulin concentrations

1974 • 102 citations

Mechanisms of Cellular Protein Catabolism

2009 • 100 citations

Energy dependence of autophagic protein degradation in isolated rat hepatocytes

1987 • 99 citations

Amino acid and hormonal control of macromolecular turnover in perfused rat liver. Evidence for selective autophagy.

1987 • 99 citations

Regulation of intracellular protein degradation in IMR‐90 human diploid fibroblasts

1983 • 99 citations

Role of protein degradation in the growth of livers after a nutritional shift

1976 • 99 citations

Smooth Endoplasmic Reticulum in Rat Hepatocytes during Glycogen Deposition and Depletion

1977 • 98 citations

Pathobiology of Cell Membranes

1980 • 92 citations

Multiphasic control of hepatic protein degradation by regulatory amino acids. General features and hormonal modulation.

1987 • 87 citations

Osmotic alterations of the lysosomal system during rat liver perfusion: Reversible suppression by insulin and amino acids

1974 • 85 citations

Cellular autophagy and cell atrophy in the rat liver during long-term starvation

1972 • 85 citations

Internalization of cytoplasmic protein by hepatic lysosomes in basal and deprivation-induced proteolytic states.

1981 • 84 citations

Protein degradation in hepatocyte monolayers. Effects of glucagon, adenosine 3':5'-cyclic monophosphate and insulin

1980 • 81 citations

Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids.

1983 • 81 citations

Compartmentation of intracellular amino acids in rat liver. Evidence for an intralysosomal pool derived from protein degradation.

1978 • 73 citations

Regulation of phenylalanine hydroxylase activity by phenylalanine in vivo, in vitro, and in perfused rat liver.

1982 • 71 citations

Suppression of cytoplasmic protein uptake by lysosomes as the mechanism of protein regain in livers of starved-refed mice.

1982 • 69 citations

Endoplasmic reticulum and autophagy in rat hepatocytes.

1978 • 69 citations

Valine Uptake and Incorporation into Protein in Isolated Rat Hepatocytes

1978 • 68 citations

Inhibition of protein degradation by anoxia and ischemia in perfused rat hearts.

1979 • 68 citations

Hepatic Autophagy in Uncontrolled Experimental Diabetes and Its Relationships to Insulin and Glucagon

1974 • 68 citations

Lysosomal degradation of ribonuclease A and ribonuclease S-protein microinjected into the cytosol of human fibroblasts.

1985 • 65 citations

LYSOSOMAL CHANGES IN RAT HEPATIC PARENCHYMAL CELLS AFTER GLUCAGON ADMINISTRATIONI

1974 • 63 citations

Protein degradation in embryonic skeletal muscle. Effect of medium, cell type, inhibitors, and passive stretch.

1980 • 62 citations

Proteolysis in homogenates of perfused rat liver: Responses to insulin, glucagon and amino acids

1973 • 62 citations

Inhibition of basal and deprivation-induced proteolysis by leupeptin and pepstatin in perfused rat liver and heart

1979 • 61 citations

Effect of isoproterenol on amino acid levels and protein turnover in skeletal muscle.

1977 • 57 citations

Lysosomal pathways in hepatic protein degradation: regulatory role of amino acids.

1984 • 54 citations

Control of proteolysis in perifused rat hepatocytes

1987 • 54 citations

Lysosomal sequestration of intracellular protein as a regulatory step in hepatic proteolysis.

1977 • 53 citations

Ultrastructural changes produced by glucagon, cyclic 3′5′-AMP and epinephrine on perfused rat livers

1971 • 53 citations

Urea synthesis in freshly isolated and in cultured periportal and perivenous hepatocytes

1986 • 53 citations

COMPARATIVE EFFECTS OF GLUCAGON, HYDROCORTISONE AND EP1NEPHRINE ON THE PROTEIN METABOLISM OF THE FASTING RAT¹²

1961 • 53 citations

Quantitative changes in the lysosomal vacuolar system of rat hepatocytes during short-term starvation

1986 • 50 citations

Role of aminoacylation of histidyl-tRNA in the regulation of protein degradation in Chinese hamster ovary cells.

1980 • 50 citations

Protein degradation in primary monolayer cultures of adult rat hepatocytes. Further evidence for the regulation of protein degradation by amino acids.

1981 • 50 citations

Changes in Effective Enzyme Concentration in the Growing Rat Liver

1961 • 49 citations

Effect of Dietary Protein on Liver Cytoplasm

1944 • 48 citations

Requirement for alanine in the amino acid control of deprivation-induced protein degradation in liver.

1984 • 46 citations

In vitro uptake of particles by lysosomes

1980 • 44 citations

Studies on the regulation of leucine catabolism in the liver. Stimulation by pyruvate and dichloroacetate.

1978 • 41 citations

Acceleration of proteolysis in perfused rat liver by deletion of glucogenic amino acids: Regulatory role of glutamine

1982 • 41 citations

Effect of leupeptin on the autophagic vacuolar system of rat hepatocytes. Correlation between ultrastructure and degradation of membrane and cytosolic proteins.

1984 • 40 citations

Intracellular protein degradation: Basis of a self-regulating mechanism for the proteolysis of endogenous proteins

1984 • 40 citations

Regression of rat liver autophagic vacuoles by locally applied cycloheximide.

1986 • 38 citations

RNA degradation in perfused rat liver as determined from the release of [14C]cytidine.

1987 • 37 citations

A morphometric study of the inhibition of autophagic degradation during restorative growth of liver cells in rats re-fed after starvation

1977 • 36 citations

Nutritional and Hormonal Effects on Intracellular Protein Catabolism

2009 • 36 citations

Lysosomes and membrane recycling. A hypothesis

1977 • 36 citations

Modulation of the amino acid control of hepatic protein degradation by caloric deprivation. Two modes of alanine co-regulation.

1988 • 35 citations

Faster protein degradation in response to decreases steady state levels of amino acylation of tRNAHis in Chinese hamster ovary cells.

1983 • 32 citations

Morphometric evaluation of the turnover of autophagic vacuoles after treatment with Triton X-100 and vinblastine in murine pancreatic acinar and seminal vesicle epithelial cells

1987 • 32 citations

Temperature dependence of protein degradation, autophagic sequestration and mitochondrial sugar uptake in rat hepatocytes

1987 • 30 citations

Regulation of lysosomal fusion during deprivation-induced autophagy in perfused rat liver

1987 • 25 citations

Degradation of intra- and extrahepatic protein by livers of normal and diabetic mice: differential responses to starvation.

1982 • 24 citations

Alteration of lysosomal density by sequestered glycogen during deprivation-induced autophagy in rat liver

1979 • 21 citations

Subcellular Distribution of Proteolytically Generated Valine in Isolated Rat Hepatocytes

1980 • 20 citations

Acute effects of isoproterenol on cellular autophagy

1981 • 16 citations

Morphological aspects of intracellular protein-degradation: autophagy.

1981 • 11 citations

Control of proteolysis in isolated rat hepatocytes

1986 • 5 citations