Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine

Chapter 4 Preparation of Isolated Rat Liver Cells

1976 • 5,335 citations

CYTOPLASMIC COMPONENTS IN HEPATIC CELL LYSOSOMES

1962 • 803 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

Cathepsin L

1977 • 341 citations

Ammonia inhibits phagosome–lysosome fusion in macrophages

1980 • 339 citations

Induction of autophagy by amino-acid deprivation in perfused rat liver

1977 • 323 citations

Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy.

1978 • 276 citations

Fusion of Semliki forest virus with the plasma membrane can be induced by low pH.

1980 • 202 citations

Uptake and degradation of 125I-labelled asialo-fetuin by isolated rat hepatocytes

1977 • 189 citations

Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes

1980 • 172 citations

Studies on cellular autophagocytosis

1974 • 140 citations

The effects of colchicine and cytochalasin B on uptake and degradation of asialo-glycoproteins in isolated rat hepatocytes

1979 • 115 citations

Differential effects of proteinase inhibitors and amines on the lysosomal and non-lysosomal pathways of protein degradation in isolated rat hepatocytes

1980 • 114 citations

Effects of Glucagon on General Protein Degradation and Synthesis in Perfused Rat Liver

1974 • 111 citations

Effect of microtubular or translational inhibitors on general cell protein degradation. Evidence for a dual catabolic pathway

1977 • 110 citations

Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes

1981 • 102 citations

Effects of amino acids, ammonia and leupeptin on protein synthesis and degradation in isolated rat hepatocytes

1978 • 101 citations

Cellular autophagocytosis induced by deprivation of serum and amino acids in HeLa cells.

1976 • 99 citations

QUANTITATIVE CHARACTERIZATION OF DENSE BODY, AUTOPHAGIC VACUOLE, AND ACID PHOSPHATASE-BEARING PARTICLE POPULATIONS DURING THE EARLY PHASES OF GLUCAGON-INDUCED AUTOPHAGY IN RAT LIVER

1971 • 98 citations

Protein degradation in hepatocyte monolayers. Effects of glucagon, adenosine 3':5'-cyclic monophosphate and insulin

1980 • 81 citations

Increased degradation in rat liver induced by vinblastine. II. Morphologic characterization.

1980 • 76 citations

AMINO ACID CONTROL OF PROTEIN SYNTHESIS AND DEGRADATION IN ISOLATED RAT HEPATOCYTES*

1980 • 73 citations

Compartmentation of intracellular amino acids in rat liver. Evidence for an intralysosomal pool derived from protein degradation.

1978 • 73 citations

The effects of ammonium ions and chloroquine on uptake and degradation of 125I-labeled asialo-fetuin in isolated rat hepatocytes

1980 • 71 citations

Increased degradation in rat liver induced by vinblastine. I. Biochemical characterization.

1980 • 55 citations

The effect of leupeptin on intracellular digestion of asialofetuin in rat hepatocytes

1981 • 51 citations

Effects of insulin and anchorage on hepatocytic protein metabolism and amino acid transport

1981 • 49 citations

Autophagic degradation in rat liver after vinblastine treatment

1980 • 43 citations

Autophagocytosis: In vitro induction by microtubule poisons

1975 • 42 citations

Degradation of chylomicron remnant cholesteryl ester by rat hepatocyte monolayers. Inhibition by chloroquine and colchicine

1977 • 38 citations

Role of Microtubuli in the Lysosomal Degradation of Endogenous and Exogenous Protein in Isolated Rat Hepatocytes

1981 • 31 citations

Autophagocytosis in mouse seminal vesicle cells in vitro

1980 • 24 citations

Prevention by cycloheximide of neutral red-induced formation of autophagic vacuoles and krinom granules in mouse pancreatic acinar cells

1972 • 22 citations

Subcellular Distribution of Proteolytically Generated Valine in Isolated Rat Hepatocytes

1980 • 20 citations

Inhibitory effects of vinblastine on protein degradation

1980 • 20 citations