Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Chapter 4 Preparation of Isolated Rat Liver Cells

1976 • 5,335 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Cyanobacterial microcystin‐LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

1990 • 1,627 citations

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

1982 • 1,313 citations

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity

1989 • 1,032 citations

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

1987 • 947 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

1981 • 742 citations

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

1990 • 630 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

Lysosomes : their role in protein breakdown

1987 • 435 citations

Expression of 5-aminolaevulinate synthase and cytochrome P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem

1989 • 411 citations

Autophagy and other vacuolar protein degradation mechanisms

1992 • 408 citations

K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.

1992 • 368 citations

Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases

1990 • 340 citations

The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells

1991 • 330 citations

Phosphorylation of microtubule-associated proteins regulates their interaction with actin filaments.

1983 • 319 citations

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

Prelysosomal convergence of autophagic and endocytic pathways

1988 • 272 citations

Glucagon-induced autophagy and proteolysis in rat liver: mediation by selective deprivation of intracellular amino acids.

1979 • 231 citations

Cytoskeletal changes in hepatocytes induced by Microcystis toxins and their relation to hyperphosphorylation of cell proteins

1992 • 227 citations

Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes.

1990 • 218 citations

Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles

1992 • 185 citations

Ca²⁺– and Calmodulin‐Dependent Phosphorylation of Microtubule‐Associated Protein 2 and t Factor, and Inhibition of Microtubule Assembly

1983 • 180 citations

Rapid microfilament reorganization induced in isolated rat hepatocytes by microcystin-LR, a cyclic peptide toxin

1989 • 152 citations

Multifunctional Ca2+/calmodulin-dependent protein kinase: domain structure and regulation

1989 • 136 citations

KT5926, a potent and selective inhibitor of myosin light chain kinase.

1990 • 130 citations

Structure‐Function Relationships of Microcystins, Liver Tumor Promoters, in Interaction with Protein Phosphatase

1991 • 121 citations

Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes

1992 • 121 citations

Effects of amino acids, ammonia and leupeptin on protein synthesis and degradation in isolated rat hepatocytes

1978 • 101 citations

Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity

1992 • 96 citations

Okadaic acid activates microtubule‐associated protein kinase in quiescent fibroblastic cells

1990 • 96 citations

PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18.

1992 • 94 citations

Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine.

1991 • 91 citations

Effects of lysosomotropic monoamines, diamines, amino alcohols, and other amino compounds on protein degradation and protein synthesis in isolated rat hepatocytes.

1980 • 91 citations

Comparison of in vivo and in vitro toxic effects of microcystin-LR in fasted rats

1989 • 90 citations

Autophagic sequestration of 614C9sucrose, introduced into rat hepatocytes by reversible electro-permeabilization*1

1982 • 86 citations

Potent and preferential inhibition of Ca2+ / calmodulin-dependent protein kinase II by K252a and its derivative, KT5926

1991 • 82 citations

Prelysosomal and lysosomal connections between autophagy and endocytosis

1992 • 81 citations

Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid

1991 • 61 citations

Reversible hyperphosphorylation and reorganization of vimentin intermediate filaments by okadaic acid in 9L rat brain tumor cells

1992 • 59 citations

The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source

1992 • 57 citations

Evidence for acidity of prelysosomal autophagic/endocytic vacuoles (amphisomes)

1993 • 54 citations

Association of Calcium/Calmodulin‐Dependent Kinase with Cytoskeletal Preparations: Phosphorylation of Tubulin, Neurofilament, and Microtubule‐Associated Proteinsa

1986 • 53 citations

Okadaic acid induces the rapid and reversible disruption of the neurofilament network in rat dorsal root ganglion neurons

1992 • 50 citations

Use of [3H]raffinose as a specific probe of autophagic sequestration

1986 • 48 citations

Aspects of homogeneous carbon monoxide fixation: selective conversion of two carbonyl ligands on (.eta.5-C5H5)Fe(CO)3+ to C2 organic compounds

1981 • 46 citations

Insulin mediator stimulation of pyruvate dehydrogenase phosphatases

1992 • 45 citations

Autophagy and lysosomal proteolysis in the liver

1985 • 32 citations

The protein phosphatase inhibitor, okadaic acid, inhibits phosphatidylcholine biosynthesis in isolated rat hepatocytes

1991 • 32 citations

Experimental characterization of the autophagic-lysosomal pathway in isolated rat hepatocytes.

1989 • 29 citations

Tumor promotion and depletion of protein kinase C in epidermal JB6 cells

1989 • 28 citations

Autophagic sequestration of [14C]sucrose introduced into isolated rat hepatocytes by electrical and non-electrical methods

1985 • 27 citations

Phenylalanine positively modulates the cAMP‐dependent phosphorylation and negatively modulates the vasopressin‐induced and okadaic‐acid‐induced phosphorylation of phenylalanine 4‐monooxygenase in intact rat hepatocytes

1992 • 27 citations

Effect of okadaic acid on hormone- and mastoparan-stimulated phosphoinositide turnover in isolated rat hepatocytes

1991 • 20 citations

Interactions of okadaic acid with insulin action in hepatocytes: role of protein phosphatases in insulin action

1991 • 16 citations

Methods in laboratory investigation. Application of test substances to the surface of rat liver in situ: opposite effects of insulin and isoproterenol on cellular autophagy.

1984 • 15 citations

Phorbol ester-induced reorganization of the cytoskeleton in human fibroblasts during ageing in vitro

1992 • 15 citations

Convergence of autophagic and endocytic pathways at the level of the lysosome

1987 • 14 citations

Homologous and heterologous β-adrenergic desensitization in hepatocytes. Additivity and effect of pertussis toxin

1988 • 10 citations

Historical Fragments; Methods; Some Terminology

1989 • 8 citations