Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes.

Chapter 4 Preparation of Isolated Rat Liver Cells

1976 • 5,335 citations

Methoden der enzymatischen Analyse

1962 • 3,983 citations

PYRUVIC ACID

1943 • 1,944 citations

3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

1982 • 1,313 citations

Protein turnover in mammalian tissues and in the whole body

1978 • 1,237 citations

A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

1989 • 932 citations

Assay of tyrosine transaminase activity by conversion of p-hydroxyphenylpyruvate to p-hydroxybenzaldehyde

1966 • 762 citations

Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors.

1968 • 742 citations

The Roles of Synthesis and Degradation in the Control of Rat Liver Tryptophan Pyrrolase

1965 • 592 citations

Degradation from the endoplasmic reticulum: Disposing of newly synthesized proteins

1988 • 488 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

Ubiquitin-mediated protein degradation.

1988 • 453 citations

Amine synthesis in regenerating rat liver: extremely rapid turnover of ornithine decarboxylase.

1969 • 380 citations

[59] Inhibitors of lysosomal function

1983 • 331 citations

Induction of autophagy by amino-acid deprivation in perfused rat liver

1977 • 323 citations

Turnover of Rat Liver Tyrosine Transaminase: Stabilization after Inhibition of Protein Synthesis

1967 • 287 citations

Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy.

1978 • 276 citations

Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion

1987 • 274 citations

Prelysosomal convergence of autophagic and endocytic pathways

1988 • 272 citations

The multicatalytic proteinase of mammalian cells

1989 • 242 citations

Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells

1976 • 234 citations

Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase

1988 • 179 citations

Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes

1980 • 172 citations

Studies on the Induction and Repression of Enzymes in Rat Liver

1968 • 169 citations

Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine

1982 • 162 citations

Amino acid control of autophagic sequestration and protein degradation in isolated rat hepatocytes.

1984 • 150 citations

Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria.

1982 • 147 citations

Multifunctional control of amino acids of deprivation-induced proteolysis in liver. Role of leucine.

1982 • 139 citations

Sequestration of cytoplasmic enzymes in an autophagic vacuole-lysosomal system induced by injection of leupeptin.

1983 • 128 citations

Differential effects of proteinase inhibitors and amines on the lysosomal and non-lysosomal pathways of protein degradation in isolated rat hepatocytes

1980 • 114 citations

Effect of microtubular or translational inhibitors on general cell protein degradation. Evidence for a dual catabolic pathway

1977 • 110 citations

Energy Dependence of Different Steps in the Autophagic-Lysosomal Pathway

1989 • 106 citations

Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes

1981 • 102 citations

Autophagic sequestration of 614C9sucrose, introduced into rat hepatocytes by reversible electro-permeabilization*1

1982 • 86 citations

An Enzyme that Synthesizes Cystathionine and Deaminates l-Serine

1959 • 83 citations

Appearance of Autolysosomes in Rat Liver after Leupeptin Treatment

1982 • 76 citations

The half-lifetime of induced tryptophan peroxidase in vivo

1959 • 74 citations

Lysosomal degradation of ribonuclease A and ribonuclease S-protein microinjected into the cytosol of human fibroblasts.

1985 • 65 citations

Inhibition of hepatocytic protein degradation by methylaminopurines and inhibitors of protein synthesis

1981 • 62 citations

An endogenous activator of the Ca2+-dependent proteinase of human neutrophils that increases its affinity for Ca2+.

1988 • 57 citations

Turnover of Several Glycolytic Enzymes in Rat Liver

1970 • 56 citations

Effects of insulin and anchorage on hepatocytic protein metabolism and amino acid transport

1981 • 49 citations

A Simple Perfusion Technique Applied to Glucocorticoid Regulation of Tryptophan Oxygenase Turnover and Bile Production in the Isolated Rat Liver

1969 • 49 citations

Use of [3H]raffinose as a specific probe of autophagic sequestration

1986 • 48 citations

The Preparation and Characterization of Pure Rat Liver Glucokinase

1974 • 47 citations

Ultrastructural studies on autolysosomes in rat hepatocytes after leupeptin treatment

1983 • 37 citations

Peptide signals for protein degradation within lysosomes.

1989 • 35 citations

Studies on ornithine decarboxylase activity in the isolated perfused rat liver

1977 • 35 citations

Calcium-activated proteolytic activity in rat liver mitochondria

1982 • 34 citations

A convenient and highly sensitive spectrophotometric assay for tryptophan 2,3-dioxygenase

1982 • 33 citations

Leucine inhibition of autophagic vacuole formation in isolated rat hepatocytes

1981 • 32 citations

Conversion of dense lysosomes into light lysosomes during hepatocytic autophagy

1985 • 32 citations

RNA and amine synthesis in the liver of rats given injections of thioacetamide.

1970 • 30 citations

Use of digitonin extraction to distinguish between autophagic-lysosomal sequestration and mitochondrial uptake of [14C]sucrose in hepatocytes

1985 • 30 citations

Intracellular protein degradation in serum-deprived human fibroblasts

1986 • 29 citations

Experimental characterization of the autophagic-lysosomal pathway in isolated rat hepatocytes.

1989 • 29 citations

Differences in the half‐lives of some mitochondrial rat liver enzymes may derive partially from hepatocyte heterogeneity

1987 • 29 citations

Inhibitors and pathways of hepatocytic protein degradation.

1981 • 28 citations

Intermediate filament-ubiquitin diseases: implications for cell sanitization.

1989 • 27 citations

l-Tryptophan inhibition of tyrosine aminotransferase degradation in rat liver in vivo

1973 • 25 citations

A possible method for estimating hormone effects on enzyme synthesis

1969 • 25 citations

Proteolysis in cultured cells during prolonged serum deprivation and replacement

1986 • 24 citations

Hepatic Glucokinase Turnover in Intact and Adrenalectomized Rats in vivo,

2005 • 22 citations

Accelerated Turnover of Hepatic Glucokinase in Starved and Streptozotocin‐Diabetic Rat

1982 • 20 citations

Tyrosine transaminase degradation in perfused liver after inhibition of protein synthesis by cycloheximide

1969 • 18 citations

Sugar uptake by fluid-phase pinocytosis and diffusion in isolated rat hepatocytes

1987 • 18 citations

Use of electrical methods in the study of hepatocytic autophagy.

1986 • 13 citations

Effects of protein-degradation inhibitors on the inactivation of tyrosine aminotransferase, tryptophan oxygenase and benzopyrene hydroxylase in isolated rat hepatocytes

1982 • 13 citations

IN VIVO DETERMINATION OF RATES OF PROTEIN DEGRADATION IN LIVERS OF MEAL-FED RATS: IMPLICATIONS OF AMINO ACID COMPARTMENTATION

1978 • 12 citations

Identification of tryptophan pyrrolase in liver lysosomes after treatment of rats with hydrocortisone and chloroquine

1978 • 11 citations

Radiolabelled sugars as probes of hepatocytic autophagy.

1986 • 11 citations

Degradation of aspartate aminotransferase in rat liver lysosomes

1988 • 7 citations