Endogenous Presenilin-1 Targets to Endocytic Rather Than Biosynthetic Compartments

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

Aggresomes: A Cellular Response to Misfolded Proteins

1998 • 2,116 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 • 1,880 citations

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER

1989 • 1,685 citations

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 • 1,467 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Rab11 regulates recycling through the pericentriolar recycling endosome.

1996 • 1,293 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies

1991 • 903 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

Immunoglobulin heavy chain binding protein

1983 • 849 citations

Presenilin is required for activity and nuclear access of Notch in Drosophila

1999 • 801 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1995 • 705 citations

Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides

1997 • 698 citations

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells.

1983 • 636 citations

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.

1989 • 588 citations

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

1996 • 549 citations

SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane.

1991 • 544 citations

Recycling of E-Cadherin

1999 • 538 citations

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants

1999 • 494 citations

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1996 • 481 citations

Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes

1998 • 479 citations

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

1993 • 460 citations

Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1997 • 443 citations

A detergent-insoluble membrance compartment contains Aβ in vivo

1998 • 394 citations

Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.

1997 • 388 citations

Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42

1999 • 381 citations

The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

1998 • 373 citations

Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons

1998 • 356 citations

Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer’s Disease: Neuropathologic Evidence for a Mechanism of Increased β-Amyloidogenesis

1997 • 348 citations

The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

1998 • 329 citations

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

1997 • 321 citations

A quantitative analysis of the endocytic pathway in baby hamster kidney cells.

1989 • 315 citations

Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons

1999 • 310 citations

Intracellular Generation and Accumulation of Amyloid β-Peptide Terminating at Amino Acid 42

1997 • 302 citations

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1997 • 299 citations

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1997 • 289 citations

Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins

1997 • 283 citations

A Role for Presenilin-1 in Nuclear Accumulation of Ire1 Fragments and Induction of the Mammalian Unfolded Protein Response

1999 • 281 citations

Hepatitis B surface antigen assembles in a post-ER, pre-Golgi compartment.

1992 • 277 citations

Cell Surface Presenilin-1 Participates in the γ-Secretase-like Proteolysis of Notch

1999 • 268 citations

A mutation in Alzheimerʼs disease destroying a splice acceptor site in the presenilin-1 gene

1995 • 251 citations

The Alzheimer’s Disease-Associated Presenilins Are Differentially Phosphorylated Proteins Located Predominantly within the Endoplasmic Reticulum

1996 • 229 citations

Presenilin-1 Forms Complexes with the Cadherin/Catenin Cell–Cell Adhesion System and Is Recruited to Intercellular and Synaptic Contacts

1999 • 221 citations

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

1997 • 219 citations

Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos

1998 • 217 citations

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.

1996 • 203 citations

Characterization of Sorting Signals in the β-Amyloid Precursor Protein Cytoplasmic Domain

1995 • 194 citations

Amyloid β protein (Aβ) deposition in chromosome 14–linked Alzheimer's disease: Predominance of Aβ₄₂₍₄₃₎

1996 • 183 citations

MG-160

1989 • 168 citations

Light and Electron Microscopic Localization of Presenilin-1 in Primate Brain

1997 • 166 citations

Direct association of presenilin‐1 with β‐catenin

1998 • 159 citations

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions.

1992 • 159 citations

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

1997 • 155 citations

Subcellular Distribution and Turnover of Presenilins in Transfected Cells

1998 • 147 citations

Evidence for phosphorylation and oligomeric assembly of presenilin 1

1997 • 145 citations

Apical and basolateral endosomes of MDCK cells are interconnected and contain a polarized sorting mechanism.

1996 • 135 citations

Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells

1997 • 135 citations

The Transmembrane Domain of a Carboxyl-terminal Anchored Protein Determines Localization to the Endoplasmic Reticulum

1997 • 122 citations

Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport

1999 • 101 citations

Immunocytochemical visualization of the Golgi apparatus in several species, including human, and tissues with an antiserum against MG-160, a sialoglycoprotein of rat Golgi apparatus.

1990 • 86 citations

Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment

1997 • 75 citations

Late Compartments of Amyloid Precursor Protein Transport in SY5Y Cells Are Involved in β-Amyloid Secretion

1997 • 69 citations

In AtT20 and HeLa cells brefeldin A induces the fusion of tubular endosomes and changes their distribution and some of their endocytic properties.

1992 • 66 citations

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

1999 • 65 citations

Cell surface expression of the Alzheimer disease-related presenilin proteins

1997 • 63 citations

Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization

1995 • 62 citations

Presenilin‐1 protein expression in familial and sporadic Alzheimer's disease

1997 • 45 citations

Enrichment of Presenilin 1 Peptides in Neuronal Large Dense‐Core and Somatodendritic Clathrin‐Coated Vesicles

1998 • 43 citations

Nerve growth factor stimulates GAP‐43 expression in PC12 cell clones independently of neurite outgrowth

1993 • 29 citations

Synaptophysin has a selective distribution in early endosomes of PC12 cells

1993 • 13 citations