Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER

1989 • 1,685 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

1990 • 918 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

A New Generation of Animal Cell Expression Vectors Based on the Semliki Forest Virus Replicon

1991 • 899 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

1992 • 726 citations

Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons

1992 • 612 citations

Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum.

1989 • 581 citations

The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway

1995 • 559 citations

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

1993 • 557 citations

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

1996 • 549 citations

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

1993 • 546 citations

Pre- and post-golgi vacuoles operate in the transport of semliki forest virus membrane glycoproteins to the cell surface

1984 • 523 citations

Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1997 • 443 citations

NTera 2 Cells: A human cell line which displays characteristics expected of a human committed neuronal progenitor cell

1993 • 435 citations

Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR

1990 • 426 citations

Retrieval of transmembrane proteins to the endoplasmic reticulum.

1993 • 414 citations

Multiple targets for brefeldin A

1991 • 347 citations

Metabolism of the “Swedish” Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells

1996 • 308 citations

The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway.

1990 • 283 citations

Identification of an intermediate compartment involved in protein transport from endoplasmic reticulum to Golgi apparatus.

1990 • 252 citations

Temperature-sensitive steps in the transport of secretory proteins through the Golgi complex in exocrine pancreatic cells.

1986 • 251 citations

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.

1993 • 223 citations

Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells.

1993 • 213 citations

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.

1996 • 203 citations

Characterization of Sorting Signals in the β-Amyloid Precursor Protein Cytoplasmic Domain

1995 • 194 citations

Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4695 mRNA is predominantly produced in rat and human brain

1990 • 183 citations

Amyloids and Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation

1996 • 167 citations

Expression patterns of β‐amyloid precursor protein (β‐APP) in neural and nonneural human tissues from alzheimer's disease and control subjects

1991 • 148 citations

Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

1995 • 148 citations

Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.

1995 • 130 citations

Enhanced Release of Amyloid -Protein from Codon 670/671 Swedish Mutant -Amyloid Precursor Protein Occurs in Both Secretory and Endocytic Pathways

1996 • 129 citations

Intracellular Accumulation of β-Amyloid in Cells Expressing the Swedish Mutant Amyloid Precursor Protein

1995 • 100 citations

Mutant and native human β-amyloid precursor proteins in transgenic mouse brain

1995 • 39 citations

Serine Phosphorylation of the Secreted Extracellular Domain of APP

1993 • 27 citations

Missense Mutations Associated with Familial Alzheimer's Disease in Sweden Lead to the Production of the Amyloid Peptide without Internalization of Its Precursor

1996 • 22 citations

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