The Alzheimer’s Disease-Associated Presenilins Are Differentially Phosphorylated Proteins Located Predominantly within the Endoplasmic Reticulum

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Normal and Abnormal Biology of the beta-Amyloid Precursor Protein

1994 • 813 citations

A Familial Alzheimer's Disease Locus on Chromosome 1

1995 • 810 citations

Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide

1993 • 809 citations

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1995 • 705 citations

Apolipoprotein E and Alzheimer disease.

1995 • 697 citations

The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway

1995 • 559 citations

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

1996 • 549 citations

Calnexin: a membrane-bound chaperone of the endoplasmic reticulum

1994 • 533 citations

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

1992 • 458 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

1995 • 453 citations

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

1993 • 401 citations

Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3

1992 • 332 citations

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor

1994 • 317 citations

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.

1993 • 279 citations

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

1991 • 276 citations

Mutations of the presenilin I gene in families with early-onset Alzheimer's disease

1995 • 270 citations

Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity

1995 • 265 citations

Casein kinases: pleiotropic mediators of cellular regulation

1993 • 264 citations

A mutation in Alzheimerʼs disease destroying a splice acceptor site in the presenilin-1 gene

1995 • 251 citations

Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.

1991 • 217 citations

Lectin-binding sites as markers of Golgi subcompartments: proximal-to-distal maturation of oligosaccharides.

1983 • 202 citations

Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail.

1995 • 184 citations

Genetics and molecular advances in Alzheimer's disease

1993 • 183 citations

Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3

1995 • 179 citations

Glutamate receptor phosphorylation and synaptic plasticity

1994 • 175 citations

The presenilin genes: a new gene family involved in Alzheimer disease pathology

1996 • 165 citations

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions.

1992 • 159 citations

Complete analysis of the presenilin 1 gene in early onset Alzheimerʼs disease

1996 • 151 citations

The Origin of Hypotheses, Illustrated by the Discussion of a Topographic Problem

1896 • 149 citations

Protein tyrosine sulfation

1987 • 135 citations

Cell biological studies with monoclonal and polyclonal antibodies against human casein kinase II subunit beta demonstrate participation of the kinase in mitogenic signaling.

1993 • 118 citations

Amyloid beta amyloidosis in Alzheimerʼs disease

1995 • 102 citations

Recombinant human casein kinase II

1994 • 78 citations

Regional and CellularPresenilin 1Gene Expression in Human and Rat Tissues

1996 • 70 citations

Breakpoint characterization of the ret/PTC oncogene in human papillary thyroid carcinoma

1995 • 59 citations

Presenile because of presenilin

1996 • 50 citations