Modulation of the NF-κB pathway by virally encoded Death Effector Domains-containing proteins

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

The Receptor for the Cytotoxic Ligand TRAIL

1997 • 1,755 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV

1996 • 926 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

1997 • 685 citations

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

1997 • 576 citations

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

1998 • 531 citations

NF-κB as a Frequent Target for Immunosuppressive and Anti-Inflammatory Molecules**This article was accepted for publication on 27 September 1996.

1997 • 472 citations

The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen

1997 • 447 citations

Transcription Mapping of the Kaposi’s Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Genome in a Body Cavity-Based Lymphoma Cell Line (BC-1)

1998 • 445 citations

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

1997 • 433 citations

Casper Is a FADD- and Caspase-Related Inducer of Apoptosis

1997 • 398 citations

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1997 • 372 citations

Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.

1994 • 358 citations

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.

1996 • 352 citations

A Novel Family of Viral Death Effector Domain-containing Molecules That Inhibit Both CD-95- and Tumor Necrosis Factor Receptor-1-induced Apoptosis

1997 • 343 citations

FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis

1997 • 339 citations

CASH, a Novel Caspase Homologue with Death Effector Domains

1997 • 323 citations

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

1997 • 316 citations

Anatomy of TRAF2

1996 • 302 citations

Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8).

1998 • 298 citations

TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.

1996 • 283 citations

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

1997 • 256 citations

MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclX _L and initiates cell death

1997 • 238 citations

I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

1996 • 210 citations

An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis

1999 • 207 citations

Correction of Radiation Sensitivity in Ataxia Telangiectasia Cells by a Truncated IκB-α

1995 • 173 citations

A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other.

1996 • 134 citations

Biological and biochemical inhibitors of the NF-κB/Rel proteins and cytokine synthesis

1996 • 130 citations

Tumor Necrosis Factor (TNF) Receptor 1 Signaling Downstream of TNF Receptor-associated Factor 2

1997 • 117 citations

The role of Rel/NF-κB proteins in viral oncogenesis and the regulation of viral transcription

1997 • 74 citations

PATHOGENESIS OF AIDS-RELATED KAPOSI'S SARCOMA

1996 • 45 citations

Some Aspects of the Pathogenesis of HIV-1-Associated Kaposi's Sarcoma

1998 • 40 citations

Molluscum contagiosum virus

1997 • 35 citations

AIDS-RELATED KAPOSI'S SARCOMA

1996 • 32 citations

Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV8)—a new human tumour virus

1997 • 29 citations