Biology of Hodgkin's lymphoma

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]

1994 • 6,495 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

1997 • 780 citations

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

1996 • 749 citations

Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.

1994 • 691 citations

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

1993 • 691 citations

Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription

2000 • 493 citations

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

2001 • 454 citations

Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription Initiation

1996 • 424 citations

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma

2002 • 407 citations

High Expression of the CC Chemokine TARC in Reed-Sternberg Cells

1999 • 379 citations

Differentiation-Linked Leukemogenesis in Lymphocytes

1986 • 359 citations

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IκBα

1999 • 347 citations

Origin of Nodular Lymphocyte-Predominant Hodgkin's Disease from a Clonal Expansion of Highly Mutated Germinal-Center B Cells

1997 • 335 citations

THE ORIGIN OF HODGKIN AND REED/STERNBERG CELLS IN HODGKIN'S DISEASE

1998 • 314 citations

Clonal Deleterious Mutations in the Iκbα Gene in the Malignant Cells in Hodgkin's Lymphoma

2000 • 287 citations

Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription

2001 • 287 citations

Hodgkin and Reed–Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells

1997 • 276 citations

European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes

2000 • 270 citations

Overexpression of I Kappa B Alpha Without Inhibition of NF-κB Activity and Mutations in the I Kappa B Alpha Gene in Reed-Sternberg Cells

1999 • 267 citations

Leu M1 and Peanut Agglutinin Stain the Neoplastic Cells of Hodgkin’s Disease

1984 • 265 citations

Somatic Hypermutation in the Heavy Chain Locus Correlates with Transcription

1998 • 265 citations

Identification of Common Germinal-Center B-Cell Precursors in Two Patients with Both Hodgkin's Disease and Non-Hodgkin's Lymphoma

1999 • 264 citations

Constitutive NF-κB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells

2001 • 263 citations

Rare Occurrence of Classical Hodgkin's Disease as a T Cell Lymphoma

2000 • 217 citations

Detection of clonal T-cell receptor gamma-chain gene rearrangements in Reed-Sternberg cells of classic Hodgkin disease

2000 • 214 citations

Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?

1997 • 192 citations

Somatic Mutation of the Cd95 Gene in Human B Cells as a Side-Effect of the Germinal Center Reaction

2000 • 186 citations

Molecular biology of Hodgkin's lymphoma

2002 • 159 citations

Clonality in Nodular Lymphocyte-Predominant Hodgkin's Disease

1997 • 157 citations

Recent Results on the Biology of Hodgkin and Reed-Sternberg Cells. I. Biopsy Material

1992 • 145 citations

Oct-2 and Bob-1 deficiency in Hodgkin and Reed Sternberg cells.

2001 • 144 citations

The Transcription Factor PU.1, Necessary for B-Cell Development Is Expressed in Lymphocyte Predominance, But Not Classical Hodgkin’s Disease

2001 • 142 citations

Hodgkin and Reed-Sternberg–like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell–derived clones: potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease

2000 • 135 citations

Classical Hodgkin's Disease and Follicular Lymphoma Originating From the Same Germinal Center B Cell

1999 • 134 citations

Germinal Center Founder Cells Display Propensity for Apoptosis before Onset of Somatic Mutation

1997 • 126 citations

Survival and Clonal Expansion of Mutating “Forbidden” (Immunoglobulin Receptor–Deficient) Epstein-Barr Virus–Infected B Cells in Angioimmunoblastic T Cell Lymphoma

2001 • 116 citations

Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells.

2000 • 104 citations

Characterization of NF-κB Expression in Hodgkin's Disease: Inhibition of Constitutively Expressed NF-κB Results in Spontaneous Caspase-Independent Apoptosis in Hodgkin and Reed-Sternberg Cells

2001 • 104 citations

Common Germinal-Center B-Cell Origin of the Malignant Cells in Two Composite Lymphomas, Involving Classical Hodgkin’s Disease and Either Follicular Lymphoma or B-CLL

2001 • 97 citations

Mutation of the p53 Gene Is Not a Typical Feature of Hodgkin and Reed-Sternberg Cells in Hodgkin’s Disease

1999 • 85 citations

The origin of CD95-gene mutations in B-cell lymphoma

2002 • 79 citations

Cultivated H-RS cells are resistant to CD95L-mediated apoptosis despite expression of wild-type CD95

2000 • 71 citations

TP53 gene mutations in Hodgkin lymphoma are infrequent and not associated with absence of Epstein-Barr virus

2001 • 61 citations

MDM2 gene amplification and lack of p53 point mutations in Hodgkin and Reed–Sternberg cells: results from single‐cell polymerase chain reaction and molecular cytogenetic studies

2001 • 58 citations

Hodgkin’s cells express CD83, a dendritic cell lineage associated antigen

1997 • 57 citations

Formation of multinucleated cells in a Hodgkin's‐disease‐derived cell line

1989 • 55 citations

Clonality and germinal centre B-cell derivation of Hodgkin/Reed–Sternberg cells in Hodgkin’s disease

1998 • 54 citations

The Reed–Sternberg cell in classical Hodgkin's disease

2001 • 53 citations

Demonstration of light chain mRNA in Hodgkin's disease

1993 • 48 citations

Analysis of T-Cell Subpopulations in T-Cell Non-Hodgkin’s Lymphoma of Angioimmunoblastic Lymphadenopathy with Dysproteinemia Type by Single Target Gene Amplification of T Cell Receptor- β Gene Rearrangements

2001 • 43 citations

Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions

2001 • 41 citations

Molecular Single-Cell Analysis of Hodgkin- and Reed-Sternberg Cells Harboring Unmutated Immunoglobulin Variable Region Genes

2001 • 33 citations

The clonal relationship between nodular sclerosis Hodgkin's disease with a clonal Reed-Sternberg cell population and a subsequent B-cell small noncleaved cell lymphoma.

1998 • 27 citations

Hodgkin's disease: The sternberg-reed cell

1987 • 20 citations

Cell fusion is not involved in the generation of giant cells in the Hodgkin‐Reed Sternberg cell line L1236

2001 • 17 citations

Light-chain mRNA in lymphocyte-predominant and mixed-cellularity Hodgkin's disease.

1996 • 15 citations

Differentiation mechanisms and malignancy.

2000 • 13 citations

The origins of Hodgkinʼs disease

1995 • 9 citations