Selective Degradation of Cytosolic Proteins by Lysosomes^a

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

1989 • 932 citations

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

1990 • 756 citations

Peptide sequences that target cytosolic proteins for lysosomal proteolysis

1990 • 674 citations

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.

1990 • 435 citations

Lysosomes : their role in protein breakdown

1987 • 435 citations

An Ancient Developmental Induction: Heat-Shock Proteins Induced in Sporulation and Oogenesis

1986 • 294 citations

Molecular determinants of protein half‐lives in eukaryotic cells

1987 • 268 citations

Peptide sequences that target proteins for enhanced degradation during serum withdrawal.

1988 • 238 citations

Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes.

1990 • 218 citations

Protein and peptide binding and stimulation of in vitro lysosomal proteolysis by the 73-kDa heat shock cognate protein.

1992 • 201 citations

Sequestration of cytoplasmic enzymes in an autophagic vacuole-lysosomal system induced by injection of leupeptin.

1983 • 128 citations

Degradation of proteins microinjected into IMR-90 human diploid fibroblasts.

1981 • 121 citations

Uptake and degradation of proteins by isolated rat liver lysosomes. Suggestion of a microautophagic pathway of proteolysis.

1982 • 118 citations

Regulation of catabolism of microinjected ribonuclease A. Identification of residues 7-11 as the essential pentapeptide.

1986 • 117 citations

Lysosomal degradation of ribonuclease A and ribonuclease S-protein microinjected into the cytosol of human fibroblasts.

1985 • 65 citations

Regulation of lysosomal autophagy in transformed and non-transformed mouse fibroblasts under several growth conditions*1

1984 • 57 citations

Secretion of Intact Proteins and Peptide Fragments by Lysosomal Pathways of Protein Degradation

1989 • 48 citations

Autophagy of metabolically inert substances injected into fibroblasts in culture

1981 • 47 citations

Covalent linkage of ribonuclease S-peptide to microinjected proteins causes their intracellular degradation to be enhanced during serum withdrawal.

1986 • 45 citations

Peptide signals for protein degradation within lysosomes.

1989 • 35 citations

Microinjection of cultured cells using red-cell-mediated fusion and osmotic lysis of pinosomes: A review of methods and applications

1984 • 35 citations

The regulation of proteolysis in normal fibroblasts as they approach confluence. Evidence for the participation of the lysosomal system

1982 • 28 citations

Na+-gradient-dependent stimulation of renal transport of ρ-aminohippurate

1982 • 27 citations