Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

Biogenesis of Mitochondria

1988 • 1,396 citations

Homologous plant and bacterial proteins chaperone oligomeric protein assembly

1988 • 1,316 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria

1989 • 933 citations

Proteins as molecular chaperones

1987 • 910 citations

Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.

1986 • 896 citations

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

Expression of wild-type and mutant forms of influenza hemagglutinin: The role of folding in intracellular transport

1986 • 879 citations

Mitochondrial protein import

1989 • 820 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Nucleosomes are assembled by an acidic protein which binds histones and transfers them to DNA

1978 • 763 citations

KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene

1989 • 684 citations

Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis

1989 • 676 citations

Protein Sorting to Mitochondria: Evolutionary Conservations of Folding and Assembly

1990 • 494 citations

Molecular chaperones: proteins essential for the biogenesis of some macromolecular structures

1989 • 491 citations

Transport of proteins into mitochondria: Translocational intermediates spanning contact sites between outer and inner membranes

1985 • 470 citations

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.

1990 • 435 citations

Purification and properties of groE, a host protein involved in bacteriophage assembly

1979 • 426 citations

S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP

1989 • 421 citations

Assembly of influenza hemagglutinin trimers and its role in intracellular transport.

1986 • 413 citations

Conformational stability of globular proteins

1990 • 390 citations

70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria.

1988 • 380 citations

Complex Interactions Among Members of an Essential Subfamily of hsp70 Genes in Saccharomyces Cerevisiae

1987 • 358 citations

Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein.

1987 • 343 citations

Transport into mitochondria and intramitochondrial sorting of the Fe/S protein of ubiquinol-cytochrome c reductase

1986 • 340 citations

Characterization of the yeast HSP60 gene coding for a mitochondrial assembly factor

1989 • 335 citations

Mitochondrial protein import: Nucleoside triphosphates are involved in conferring import-competence to precursors

1987 • 322 citations

THE MITOCHONDRIAL PROTEIN IMPORT APPARATUS

1990 • 311 citations

[31] Use of protein A—bearing staphylococci for the immunoprecipitation and isolation of antigens from cells

1981 • 307 citations

Coming in from the cold

1988 • 285 citations

Successive translocation into and out of the mitochondrial matrix: Targeting of proteins to the intermembrane space by a bipartite signal peptide

1987 • 275 citations

Isolation and characterization of STI1, a stress-inducible gene from Saccharomyces cerevisiae.

1989 • 248 citations

SSC1, an Essential Member of the Yeast HSP70 Multigene Family, Encodes a Mitochondrial Protein

1989 • 242 citations

Complex interactions among members of an essential subfamily of hsp70 genes in Saccharomyces cerevisiae.

1987 • 225 citations

Heavy-chain binding protein recognizes aberrant polypeptides translocated in vitro

1988 • 219 citations

Characterization of translocation contact sites involved in the import of mitochondrial proteins.

1987 • 219 citations

Translocation arrest by reversible folding of a precursor protein imported into mitochondria. A means to quantitate translocation contact sites.

1989 • 212 citations

Identification of heat shock protein hsp70 homologues in chloroplasts.

1990 • 206 citations

SSC1, a member of the 70-kDa heat shock protein multigene family of Saccharomyces cerevisiae, is essential for growth.

1987 • 205 citations

Identification, characterization, and purification of two mammalian stress proteins present in mitochondria, grp 75, a member of the hsp 70 family and hsp 58, a homolog of the bacterial groEL protein

1989 • 199 citations

Seventy-kilodalton heat shock proteins and an additional component from reticulocyte lysate stimulate import of M13 procoat protein into microsomes.

1988 • 187 citations

Heat-shock proteins DnaK and GroEL facilitate export of LacZ hybrid proteins in E. coli

1990 • 175 citations

Import pathways of precursor proteins into mitochondria: multiple receptor sites are followed by a common membrane insertion site.

1988 • 159 citations

Transport and routing of proteins into chloroplasts

1989 • 155 citations

The processing peptidase of yeast mitochondria: the two co-operating components MPP and PEP are structurally related.

1988 • 152 citations

Import of proteins into mitochondria: a multi‐step process

1988 • 147 citations

Translocation of proteins into isolated chloroplasts requires cytosolic factors to obtain import competence

1990 • 142 citations

SSC1, an essential member of the yeast HSP70 multigene family, encodes a mitochondrial protein.

1989 • 137 citations

Mitochondrial protein import: involvement of the mature part of a cleavable precursor protein in the binding to receptor sites.

1987 • 134 citations

Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes

1990 • 118 citations

A yeast mutant temperature-sensitive for mitochondrial assembly is deficient in a mitochondrial protease activity that cleaves imported precursor polypeptides.

1985 • 107 citations

Molecular cloning of mtp70, a mitochondrial member of the hsp70 family.

1989 • 97 citations

Mitochondrial precursor proteins are imported through a hydrophilic membrane environment

1987 • 90 citations

A member of the Hsp70 family is localized in mitochondria and resembles Escherichia coli DnaK.

1989 • 71 citations

Hsp70 proteins, similar to Escherichia coli DnaK, in chloroplasts and mitochondria of Euglena gracilis.

1990 • 69 citations