Induction of Somatic Mutation in a Human B Cell Line In Vitro

Germinal Centers

1994 • 1,680 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Intraclonal generation of antibody mutants in germinal centres

1991 • 1,083 citations

Treatment of B-Cell Lymphoma with Monoclonal Anti-Idiotype Antibody

1982 • 1,001 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

1993 • 691 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.

1991 • 641 citations

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

1995 • 481 citations

Antigen‐Driven Selection of Virgin and Memory B Cells

1986 • 476 citations

Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription Initiation

1996 • 424 citations

The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

1994 • 415 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

Antigen-induced B-cell death and elimination during germinal-centre immune responses

1995 • 377 citations

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

1990 • 318 citations

Dendritic cells capable of stimulating T cells in germinal centres

1996 • 309 citations

Antigen-driven B cell differentiation in vivo.

1993 • 308 citations

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells

1995 • 301 citations

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

1993 • 283 citations

Immunological Memory

1993 • 250 citations

Somatic hypermutation

1995 • 248 citations

Targeting of non-lg sequences in place of the V segment by somatic hyper mutation

1995 • 223 citations

Discriminating intrinsic and actigen-selected mutational hotspots in immunoglobulin V genes

1993 • 222 citations

Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family‐specific oligonucleotide probes

1991 • 215 citations

The smaller human VH gene families display remarkably little polymorphism.

1989 • 203 citations

SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES

1996 • 192 citations

Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells.

1996 • 175 citations

Patterns of Somatic Mutations in Immunoglobulin Variable Genes

1987 • 158 citations

Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.

1985 • 153 citations

Follicular Dendritic Cells and Germinal Centers

1996 • 146 citations

In Situ Studies of the Germinal Center Reaction

1995 • 139 citations

Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity

1995 • 114 citations

Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas

1993 • 107 citations

Burkitt’s Lymphoma Is a Malignancy of Mature B Cells Expressing Somatically Mutated V Region Genes

1995 • 98 citations

Development of antibody diversity in single germinal centers: selective expansion of high‐affinity variants

1994 • 85 citations

CD4+ T-cell induction of Fas-mediated apoptosis in Burkitt's lymphoma B cells

1996 • 82 citations

Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer

1993 • 77 citations

Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes.

1995 • 70 citations

Expression of a 32‐kDa ligand for the CD40 antigen on activated human T lymphocytes

1993 • 65 citations

Somatic Mutation of Immunoglobulin V Genes in Vitro

1996 • 64 citations

Generation of B cell memory and affinity maturation. Induction with Th1 and Th2 T cell clones.

1992 • 63 citations

Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro

1995 • 55 citations

Mitogen-driven B cell proliferation and differentiation are not accompanied by hypermutation of immunoglobulin variable region genes.

1987 • 48 citations

Chromosomal organization of the human VH4 gene family. Location of individual gene segments.

1993 • 47 citations

Soluble antigen can impede affinity maturation and the germinal center reaction but enhance extrafollicular immunoglobulin production.

1995 • 46 citations

Role of CD40 antigen and interleukin‐2 in T cell‐dependent human B lymphocyte growth

1994 • 45 citations

Somatic Mutation: From the dark zone to the light

1994 • 45 citations

Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line.

1995 • 37 citations

Five Human Mature B Cell Subsets

1994 • 34 citations

B-Cell Maturation Stages of Burkitt's Lymphoma Cell Lines According to Epstein-Barr Virus Status and Type of Chromosome Translocation<xref ref-type="fn" rid="FN2">2</xref>

1987 • 31 citations

A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene.

1995 • 29 citations

Anti‐CD40 plus interleukin‐4‐activated human naive B cell lines express unmutated immunoglobulin genes with intraclonal heavy chain isotype variability

1995 • 26 citations

B-cell proliferation initiated by Ia cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro.

1992 • 20 citations

A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro

1995 • 18 citations

Anti-CD3-stimulated T cells induce the production of multiple Ig H chain isotypes by individual human peripheral B lymphocytes.

1992 • 11 citations

Analysis of somatic mutation activity in multiple Vϰ genes involved in the response to 2-phenyl-5-oxazolone

1993 • 10 citations

Scope of action of the immunoglobulin mutator system

1989 • 3 citations