Discriminating intrinsic and actigen-selected mutational hotspots in immunoglobulin V genes

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1984 • 534 citations

Somatic hypermutagenesis in immunoglobulin genes

1992 • 458 citations

Biochemical Basis of DNA Replication Fidelity

1993 • 441 citations

Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications

1984 • 369 citations

The Dynamic Nature of the Antibody Repertoire

1988 • 321 citations

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

1990 • 318 citations

mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification

1983 • 301 citations

Antibody engineering for the analysis of affinity maturation of an anti-hapten response.

1988 • 275 citations

Different base/base mispairs are corrected with different efficiencies and specificities in monkey kidney cells

1988 • 230 citations

Patterns of Somatic Mutations in Immunoglobulin Variable Genes

1987 • 158 citations

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3′ of C kappa and occurs on passenger transgenes.

1991 • 132 citations

Distribution of Mutations around Rearranged Heavy-Chain Antibody Variable-Region Genes

1990 • 129 citations

Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell‐dependent antigen

1992 • 119 citations

Distribution of mutations around rearranged heavy-chain antibody variable-region genes.

1990 • 93 citations

Activation of memory and virgin B cell clones in hyperimmune animals

1987 • 90 citations

Mutational hot spots in Ig V region genes of human follicular lymphomas.

1988 • 86 citations

Somatic hypermutation in V-regions.

1991 • 75 citations

Position of the rearranged V kappa and its 5' flanking sequences determines the location of somatic mutations in the J kappa locus.

1991 • 74 citations

Molecular evolution of the human immunoglobulin E response: high incidence of shared mutations and clonal relatedness among epsilon VH5 transcripts from three unrelated patients with atopic dermatitis.

1993 • 70 citations

The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. Nonrandom silent mutation and unequal numbers of VH and Vk mutations.

1990 • 55 citations

Affinity maturation leads to differential expression of multiple copies of a κ light-chain transgene

1993 • 43 citations

Colony assays for antibody fragments expressed in bacteria

1991 • 40 citations

Immunologic memory to phosphocholine keyhole limpet hemocyanin. Recurrent mutations in the lambda 1 light chain increase affinity for antigen.

1992 • 24 citations

High Expression of a 3′→5′ Exonuclease Activity Is Specific to B Lymphocytes

1991 • 24 citations

High expression of a 3'----5' exonuclease activity is specific to B lymphocytes.

1991 • 12 citations