Role of CD40 antigen and interleukin‐2 in T cell‐dependent human B lymphocyte growth

High gradient magnetic cell separation with MACS

1990 • 1,648 citations

Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes.

1992 • 1,259 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A.

1992 • 641 citations

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1991 • 554 citations

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.

1990 • 453 citations

Germinal centres in T-cell-dependent antibody responses

1992 • 442 citations

Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones

1984 • 392 citations

Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.

1993 • 372 citations

Follicular Dendritic Cells as Accessory Cells

1990 • 351 citations

Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen.

1991 • 334 citations

Activated human T cells express a ligand for the human B cell‐associated antigen CD40 which participates in T cell‐dependent activation of B lymphocytes

1992 • 323 citations

Cloning of TRAP, a ligand for CD40 on human T cells

1992 • 280 citations

Human B Lymphocytes: Phenotype, Proliferation, and Differentiation

1992 • 255 citations

Activation of human B lymphocytes through CD40 and interleukin 4

1989 • 227 citations

Maturation and Dispersal of B‐Cell Clones during T Cell‐Dependent Antibody Responses

1992 • 206 citations

Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles. Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help.

1992 • 194 citations

Growing human B lymphocytes in the CD40 system

1991 • 177 citations

Cytokine expression by germinal center cells.

1993 • 161 citations

Soluble forms of CD40 inhibit biologic responses of human B cells.

1992 • 154 citations

Immunoregulatory role of CD40 in human B cell differentiation.

1993 • 122 citations

Germinal center T cells are distinct helper-inducer T cells

1991 • 84 citations

Human interferon-gamma acts as a B cell growth factor in the anti-IgM antibody co-stimulatory assay but has no direct B cell differentiation activity.

1986 • 77 citations

Expression of a 32‐kDa ligand for the CD40 antigen on activated human T lymphocytes

1993 • 65 citations

Human interleukin 4 down‐regulates the surface expression of CD5 on normal and leukemic B cells

1989 • 58 citations

Analysis of the mechanisms of T cell-dependent polyclonal activation of human B cells. Induction of human B cell responses by fixed activated T cells.

1991 • 52 citations

Heterogeneity of macrophage populations in human lymphoid tissue and peripheral blood

1984 • 42 citations

IL-2 and a contact-mediated signal provided by TCR alpha beta + or TCR gamma delta + CD4+ T cells induce polyclonal Ig production by committed human B cells. Enhancement by IL-5, specific inhibition of IgA synthesis by IL-4.

1992 • 35 citations

T cell clones which share T cell receptor epitopes differ in phenotype, function and specificity

1986 • 28 citations

The induction of human B-cell activation, proliferation and differentiation by anti-CD3-stimulated T cells — A model of T cell/B cell collaboration

1990 • 15 citations