Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family‐specific oligonucleotide probes

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

A Method for Isolation of Intact, Translationally Active Ribonucleic Acid

1983 • 1,469 citations

Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

1989 • 989 citations

Man-made antibodies

1991 • 935 citations

Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda

1989 • 810 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Cloning immunoglobulin variable domains for expression by the polymerase chain reaction.

1989 • 712 citations

Polymerase Chain Reaction with Single-Sided Specificity: Analysis of T Cell Receptor δ Chain

1989 • 640 citations

Early Restriction of the Human Antibody Repertoire

1987 • 546 citations

Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.

1988 • 432 citations

Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding

1982 • 348 citations

Organization of human immunoglobulin heavy chain diversity gene loci.

1988 • 317 citations

Organization and evolution of variable region genes of the human immunoglobulin heavy chain

1986 • 227 citations

A novel family of variable region genes of the human immunoglobulin heavy chain

1987 • 187 citations

A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours

1988 • 174 citations

Rapid cloning of rearranged immunoglobulin genes from human hybridoma cells using mixed primers and the polymerase chain reaction

1989 • 172 citations

A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.

1986 • 166 citations

Polymemse Chain Reaction Using Mixed Primers: Cloning of Human Monoclonal Antibody Variable Region Genes from Single Hybridoma Cells

1989 • 123 citations

Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroups.

1983 • 122 citations

The physical organization of the human immunoglobulin heavy chain gene complex.

1990 • 113 citations

Human heavy-chain variable region gene family nonrandomly rearranged in familial chronic lymphocytic leukemia.

1987 • 109 citations

Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene

1985 • 109 citations

The efficient production of stable, human monoclonal antibody-secreting hybridomas from EBV-transformed lymphocytes using the mouse myeloma X63-Ag8.653 as a fusion partner

1986 • 107 citations

Identification of human antibody fragment clones specific for tetanus toxoid in a bacteriophage lambda immunoexpression library.

1990 • 106 citations

Isolation and characterization of a light chain variable region gene for human rheumatoid factors.

1987 • 94 citations

The human VK locus

1988 • 90 citations

Genetic basis for the cross-reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies.

1986 • 87 citations

Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. III. A single VKII gene and one of several JK genes are joined by an invariant arginine to form the most common L chain V region.

1989 • 86 citations

A large section of the gene locus encoding human immunoglobulin variable regions of the Kappa type is duplicated

1985 • 80 citations

Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity.

1987 • 62 citations

A V_H gene is located within 95 Kb of the human immunoglobulin heavy chain constant region genes

1988 • 51 citations

Cloning and sequence determination of a human rheumatoid factor light-chain gene.

1986 • 47 citations

Aberrant recombination events in B cell lines derived from ax-deficient human

1985 • 37 citations

The Croonian Lecture, 1989 Antibodies: a paradigm for the biology of molecular recognition

1990 • 29 citations

A member of a novel human DH gene family: DHFL16

1989 • 24 citations

Two Unusual Human Immunoglobulin V_κGenes

1988 • 19 citations