Residual MHC Class II Expression on Mature Dendritic Cells and Activated B Cells in RFX5-Deficient Mice

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Acre-transgenic mouse strain for the ubiquitous deletion ofloxP-flanked gene segments including deletion in germ cells

1995 • 1,269 citations

Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody

1979 • 1,144 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

1995 • 959 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Positive Selection of Thymocytes

1995 • 604 citations

Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

Sequences and Factors: A Guide to MHC Class-II Transcription

1992 • 540 citations

A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.

1981 • 531 citations

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA

1997 • 510 citations

Surface Antigen Expression and Immunoglobulin Gene Rearrangement During Mouse pre‐B Cell Development

1983 • 490 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

Regulation of Major Histocompatibility Complex Class-II Genes: X, Y and Other Letters of the Alphabet

1990 • 470 citations

Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

1997 • 459 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice.

1995 • 384 citations

Targeted disruption of the MHC class II Aa gene in C57BL/6 mice

1993 • 377 citations

Invariant Chain Structure and MHC Class II Function

1996 • 374 citations

Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

1996 • 356 citations

A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).

1995 • 334 citations

The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus

1989 • 318 citations

Expansion and functional activity of Ly‐1⁺ B cells upon transfer of peritoneal cells into allotype‐congenic, newborn mice

1987 • 318 citations

Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X

1988 • 275 citations

Quantitative variation in la antigen expression plays a central role in immune regulation

1984 • 270 citations

Class II transactivator regulates the expression of multiple genes involved in antigen presentation.

1995 • 267 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency

1997 • 223 citations

Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.

1993 • 218 citations

Compartmentalization of MHC class II gene expression in transgenic mice

1988 • 201 citations

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

1994 • 196 citations

Major histocompatibility complex class II deficiency: Clinical manifestations, immunologic features, and outcome

1993 • 190 citations

Dendritic cells from mouse bone marrow: In vitro differentiation using low doses of recombinant granulocyte-macrophage colony-stimulating factor

1992 • 179 citations

Laboratory Protocols for Conditional Gene Targeting

1997 • 176 citations

Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y.

1994 • 176 citations

Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5

1997 • 140 citations

Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis.

1991 • 125 citations

Phenotypic and functional characterization of CD11c⁺ dendritic cell population in mouse Peyer's patches

1996 • 110 citations

The two novel MHC class II transactivators RFX5 and CIITA both control expression of HLA-DM genes

1995 • 106 citations

Positive selection of T cells

1995 • 106 citations

Immune Responses in MHC Class II-Deficient MICE

1995 • 101 citations

Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC class II promoters.

1994 • 97 citations

Purified X2 binding protein (X2BP) cooperatively binds the class II MHC X box region in the presence of purified RFX, the X box factor deficient in the bare lymphocyte syndrome.

1995 • 86 citations

Genetic complexity of regulatory mutants defective for HLA class II gene expression.

1992 • 76 citations

Regulation of Genes for HLA Class II Antigens in Cell Lines from Patients with Severe Combined Immunodeficiency

1988 • 74 citations

An isotype-specific trans-acting factor is defective in a mutant B cell line that expresses HLA-DQ, but not -DR or -DP.

1991 • 47 citations

Molecular characterization of major histocompatibility complex class II gene expression and demonstration of antigen-specific T cell response indicate a new phenotype in class II-deficient patients.

1995 • 47 citations

The thymus in “bare lymphocyte” syndrome: Significance of expression of major histocompatibility complex antigens on thymic epithelial cells in intrathymic T-cell maturation

1985 • 45 citations

The Immune System of Mice Lacking Conventional MHC Class II Molecules

1993 • 41 citations

Normal T cell receptor Vβ usage in a primary immunodeficiency associated with HLA class II deficiency

1993 • 40 citations

Genetic evidence for a new type of major histocompatibility complex class II combined immunodeficiency characterized by a dyscoordinate regulation of HLA-D alpha and beta chains.

1996 • 37 citations

An Isotype-specific Activator of Major Histocompatibility Complex (MHC) Class II Genes That Is Independent of Class II Transactivator

1997 • 35 citations

Analysis of mutations and chromosomal localisation of the gene encoding RFX5, a novel transcription factor affected in major histocompatibility complex class II deficiency

1997 • 27 citations

Revertants from the HLA class II regulatory mutant 6.1.6: implications for the regulation of Ia gene expression.

1984 • 22 citations

Analysis of transcripts of genes located within the HLA-D region in B cells from an HLA-severe combined immunodeficiency individual

1993 • 10 citations

The Thymus in “Bare Lymphocyte” Syndrome

1985 • 6 citations