Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis.

Role of MHC Gene Products in Immune Regulation

1981 • 705 citations

Immunofluorescence and Herpes-Type Virus Particles in the P3HR-1 Burkitt Lymphoma Cell Line

1967 • 498 citations

Regulation of Major Histocompatibility Complex Class-II Genes: X, Y and Other Letters of the Alphabet

1990 • 470 citations

Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.

1988 • 432 citations

Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.

1989 • 396 citations

A New Member of the Leucine Zipper Class of Proteins that Binds to the HLA DRα Promoter

1990 • 286 citations

Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X

1988 • 275 citations

Rapid reprogramming of globin gene expression in transient heterokaryons

1986 • 246 citations

Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets.

1983 • 205 citations

A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes

1985 • 191 citations

New Epstein–Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma

1982 • 148 citations

Cloning of the major histocompatibility complex class II promoter binding protein affected in a hereditary defect in class II gene regulation.

1989 • 141 citations

Stable variants affecting B cell alloantigens in human lymphoid cells

1978 • 109 citations

A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain.

1990 • 98 citations

A defect in the regulation of major histocompatibility complex class II gene expression in human HLA-DR negative lymphocytes from patients with combined immunodeficiency syndrome.

1985 • 86 citations

Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors

1989 • 82 citations

Bare lymphocyte syndrome: Altered HLA class II expression in B cell lines derived from two patients

1989 • 79 citations

Identification of a trans-acting function regulating HLA-DR expression in a DR-negative B cell variant

1980 • 78 citations

Reactivation by a trans-acting factor of human major histocompatibility complex Ia gene expression in interspecies hybrids between an Ia-negative human B-cell variant and an Ia-positive mouse B-cell lymphoma.

1985 • 75 citations

Regulation of Genes for HLA Class II Antigens in Cell Lines from Patients with Severe Combined Immunodeficiency

1988 • 74 citations

Trans-acting element(s) operating across species barriers positively regulate expression of major histocompatibility complex class II genes.

1985 • 73 citations

Progress in immunodeficiency research and therapy

1985 • 67 citations

Mutant human B cell lines deficient in class II major histocompatibility complex transcription.

1987 • 63 citations

HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants.

1985 • 60 citations

Evidence for two trans-acting genes regulating HLA class II antigen expression.

1985 • 52 citations

Immunochemically purified DR antigens in liposomes stimulate xenogeneic cytolytic T cells in secondary in vitro cultures

1986 • 50 citations

Two distinct genetic loci regulating class II gene expression are defective in human mutant and patient cell lines.

1988 • 46 citations

Successful treatment with an unrelated-donor bone marrow transplant in an HLA-deficient patient with severe combined immune deficiency (“bare lymphocyte syndrome”)

1990 • 35 citations

Evidence for a trans-acting factor that regulates the transcription of class II major histocompatibility complex genes: genetic and functional analysis.

1988 • 31 citations

A cDNA for a Human Cyclic AMP Response Element-Binding Protein Which Is Distinct from CREB and Expressed Preferentially in Brain

1990 • 28 citations

Bare lymphocyte syndrome. Consequences of absent class II major histocompatibility antigen expression for B lymphocyte differentiation and function.

1988 • 22 citations

Interferon-induced expression of class II major histocompatibility antigens in the major histocompatibility complex (MHC) class II deficiency syndrome

1988 • 14 citations