A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).

Basic local alignment search tool

1990 • 87,358 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Basic Local Alignment Search Tool

1990 • 12,947 citations

The scanning model for translation: an update.

1989 • 3,525 citations

A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.

1985 • 3,185 citations

In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis

1992 • 1,259 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

Prosite: a dictionary of sites and patterns in proteins

1992 • 952 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

A High-Efficiency HeLa Cell Nuclear Transcription Extract

1988 • 612 citations

Detection of a novel human class II HLA antigen

1983 • 387 citations

A New Member of the Leucine Zipper Class of Proteins that Binds to the HLA DRα Promoter

1990 • 286 citations

Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X

1988 • 275 citations

Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits.

1990 • 264 citations

Analysis of HLA-D region-associated molecules with monoclonal antibody.

1979 • 246 citations

Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets.

1983 • 205 citations

Monoclonal antibodies to NF-Y define its function in MHC class II and albumin gene transcription.

1992 • 192 citations

A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes

1985 • 191 citations

Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y.

1994 • 176 citations

In vivo footprinting of MHC class II genes: bare promoters in the bare lymphocyte syndrome

1991 • 175 citations

MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain.

1990 • 171 citations

Cloning of the major histocompatibility complex class II promoter binding protein affected in a hereditary defect in class II gene regulation.

1989 • 141 citations

RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.

1994 • 133 citations

Combined immunodeficiency with defective expression in MHC class II genes.

1989 • 131 citations

Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis.

1991 • 125 citations

Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos.

1991 • 125 citations

Mutational analysis of the DRA promoter: cis-acting sequences and trans-acting factors.

1990 • 121 citations

Stable variants affecting B cell alloantigens in human lymphoid cells

1978 • 109 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 107 citations

Distinct Cloned Class II MHC DNA Binding Proteins Recognize the X Box Transcription Element

1988 • 99 citations

Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC class II promoters.

1994 • 97 citations

Analysis by Sequential Immunoprecipitations of the Specificities of the Monoclonal Antibodies TÜ22, 34, 35, 36, 37, 39, 43, 58 and YD 1/63.HLK Directed Against Human HLA Class II Antigens

1986 • 90 citations

Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors

1989 • 82 citations

Bare lymphocyte syndrome: Altered HLA class II expression in B cell lines derived from two patients

1989 • 79 citations

Genetic complexity of regulatory mutants defective for HLA class II gene expression.

1992 • 76 citations

RFX1 is Identical to Enhancer Factor C and Functions as a Transactivator of the Hepatitis B Virus Enhancer

1993 • 74 citations

Regulation of Genes for HLA Class II Antigens in Cell Lines from Patients with Severe Combined Immunodeficiency

1988 • 74 citations

Trans-acting element(s) operating across species barriers positively regulate expression of major histocompatibility complex class II genes.

1985 • 73 citations

Functional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX.

1994 • 72 citations

MHC Class II‐Deficient Combined Immunodeficiency: A Disease of Gene Regulation

1994 • 68 citations

Two DNA-binding proteins discriminate between the promoters of different members of the major histocompatibility complex class II multigene family.

1990 • 66 citations

The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters.

1992 • 64 citations

Mutant human B cell lines deficient in class II major histocompatibility complex transcription.

1987 • 63 citations

The different level of expression of HLA-DRB1 and -DRB3 genes is controlled by conserved isotypic differences in promoter sequence

1993 • 61 citations

NF-X2 that binds to the DRA X2-box is activator protein 1. Expression cloning of c-Jun.

1990 • 57 citations

Two complementation groups account for most cases of inherited MHC class II deficiency

1994 • 55 citations

Single base pair substitutions within the HLA-DRA gene promoter separate the functions of the X1 and X2 boxes.

1992 • 52 citations

Transcription of a subset of human class II major histocompatibility complex genes is regulated by a nucleoprotein complex that contains c-fos or an antigenically related protein.

1991 • 52 citations

NF-X, a transcription factor implicated in MHC class II gene regulation.

1991 • 45 citations

Protease treatment of nuclear extracts distinguishes between class II MHC X1 box DNA-binding proteins in wild-type and class II-deficient B cells.

1993 • 45 citations

Three in vivo promoter phenotypes in MHC class II deficient combined immunodeficiency

1993 • 44 citations

Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoter-binding protein differs in the chromatin structure of the HLA-DRA gene.

1989 • 41 citations

Defective HLA DRA X box binding in the class II transactive transcription factor mutant 6.1.6 and in cell lines from class II immunodeficient patients.

1991 • 36 citations

Successful treatment with an unrelated-donor bone marrow transplant in an HLA-deficient patient with severe combined immune deficiency (“bare lymphocyte syndrome”)

1990 • 35 citations

Evidence for a trans-acting factor that regulates the transcription of class II major histocompatibility complex genes: genetic and functional analysis.

1988 • 31 citations

Transcription Analysis of Class II Human Leukocyte Antigen Genes from Normal and Immunodeficient Β Lymphocytes, Using Polymerase Chain Reaction

1990 • 23 citations

Defective Expression of HLA-D-Region Determinants in Children with Congenital Agammaglobulinemia and Malabsorption: A New Syndrome

1984 • 13 citations

Deleted Work

1955 • 0 citations