Normal T cell receptor Vβ usage in a primary immunodeficiency associated with HLA class II deficiency

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.

1989 • 1,000 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses

1991 • 783 citations

Polymerase Chain Reaction with Single-Sided Specificity: Analysis of T Cell Receptor δ Chain

1989 • 640 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Evidence for the Effects of a Superantigen in Rheumatoid Arthritis

1991 • 632 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

1992 • 531 citations

Structure, Organization and Polymorphism of Murine and Human T‐Cell Receptor a and β Chain Gene Families

1988 • 448 citations

Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain.

1985 • 416 citations

Selective expansion of T cells expressing T-cell receptor variable regions V beta 2 and V beta 8 in Kawasaki disease.

1992 • 359 citations

Selective Depletion in HIV Infection of T Cells that Bear Specific T Cell Receptor V _β Sequences

1991 • 322 citations

Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis.

1991 • 297 citations

Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X

1988 • 275 citations

Diversity and structure of human T-cell receptor alpha-chain variable region genes.

1987 • 274 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

Sequences and repertoire of the human T cell receptor α and β chain variable region genes in thymocytes

1987 • 226 citations

The extrathymic T-cell development pathway

1992 • 169 citations

The T-cell-receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal.

1991 • 169 citations

T cell receptor V-segment frequencies in peripheral blood T cells correlate with human leukocyte antigen type.

1991 • 166 citations

Variation in human T cell receptor V_β and J_β repertoire: analysis using anchor polymerase chain reaction

1992 • 164 citations

Studies on the human T cell receptor α/β variable region genes. II. Identification of four additional V_β subfamilies

1991 • 148 citations

The effects of MHC gene dosage and allelic variation on T cell receptor selection

1990 • 123 citations

Diversity and structure of human T-cell receptor beta-chain variable region genes.

1986 • 112 citations

The human T cell receptor beta-chain gene complex contains at least 57 variable gene segments. Identification of six V beta genes in four new gene families.

1991 • 105 citations

Biased expression of individual T cell receptor V gene segments in CD4⁺ and CD8⁺ human peripheral blood T lymphocytes

1991 • 98 citations

Variability in T cell receptor V beta gene usage in human peripheral blood lymphocytes. Studies of identical twins, siblings, and insulin-dependent diabetes mellitus patients.

1992 • 95 citations

Genomically imposed and somatically modified human thymocyte V beta gene repertoires.

1991 • 74 citations

New human V beta genes and polymorphic variants.

1991 • 63 citations

Immunodeficiency with low expression of the T cell receptor/CD3 complex. Effect on T lymphocyte activation

1991 • 60 citations

The genomic structure of human V beta 6 T cell antigen receptor genes.

1991 • 51 citations

Preferential expression of V_β6.7 domain on human peripheral CD4⁺ T cells. Implication for positive selection of T cells in man

1991 • 35 citations

Expression of the human V_β8 gene product preferentially correlates with class II major histocompatibility complex restriction specificity

1990 • 21 citations

Sequence and expression of a novel human T-cell receptor ?-chain variable gene segment subfamily

1990 • 20 citations

An immune response defect due to low levels of class II cell surface expression. Analysis of antigen presentation and positive selection.

1991 • 11 citations

Analysis of the expression immunoglobulin gene repertoire by screening libraries derived from PCR-amplified cDNA

1991 • 10 citations