Quantitative variation in la antigen expression plays a central role in immune regulation

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

Dendritic Cells: Features and Functions

1980 • 585 citations

Prostaglandins modulate macrophage Ia expression

1982 • 545 citations

The Regulatory Role of Macrophages in Antigenic Stimulation Part Two: Symbiotic Relationship between Lymphocytes and Macrophages

1981 • 518 citations

Genes of the Major Histocompatibility Complex of the Mouse

1983 • 445 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE

1972 • 355 citations

Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex

1975 • 276 citations

Monoclonal antibody against an Ir gene product?

1980 • 238 citations

Alloreactive cloned T cell lines. I. Interactions between cloned amplifier and cytolytic T cell lines.

1980 • 235 citations

Cooperative interaction of B lymphocytes with antigen-specific helper T lymphocytes is MHC restricted

1981 • 207 citations

Ia antigen-bearing B cell tumor lines can present protein antigen and alloantigen in a major histocompatibility complex-restricted fashion to antigen-reactive T cells.

1982 • 202 citations

The Alternative Pathway C3/C5 Convertase: Chemical Basis of Factor B Activation

1979 • 201 citations

Effects of protein insufficiency on immune responsiveness

1974 • 190 citations

HISTOCOMPATIBILITY-LINKED IMMUNE RESPONSE GENE FUNCTION IN GUINEA PIGS

1972 • 186 citations

Studies of the cell surface of mouse dendritic cells and other leukocytes

1981 • 182 citations

Identification of the Receptor for Antigen and Major Histocompatibility Complex on Human Inducer T Lymphocytes

1983 • 165 citations

Immunogenetic and Biological Aspects of in Vitro Lymphocyte Allotransformation (MLR) in the Mouse

1973 • 159 citations

T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte Proliferation with anti-Ia antisera.

1976 • 158 citations

Regulation of macrophage populations. II. Synthesis and expression of Ia antigens by peritoneal exudate macrophages is a transient event.

1981 • 153 citations

A one-receptor view of T-cell behaviour

1981 • 146 citations

Genetic and Immunological Complexity of Major Histocompatibility Regions

1972 • 137 citations

Studies on the mechanism of drug sensitization: T-cell-dependent popliteal lymph node reaction to diphenylhydantoin

1981 • 125 citations

Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in A(e):E(a), complex expression causes a corresponding defect in antigen-presenting cell function

1982 • 115 citations

T Lymphocyte-Enriched Murine Peritoneal Exudate Cells

1976 • 114 citations

The invariant chain of murine ia antigens: Its glycosylation, abundance and subcellular localization

1981 • 108 citations

T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2− andI-A restricted

1980 • 99 citations

Restricted helper function of F1 leads to parent bone marrow chimeras controlled by K-end of H-2 complex.

1978 • 96 citations

T cell regulation of B cell activation. I-A-restricted T suppressor cells inhibit the major histocompatibility complex-restricted interactions of T helper cells with B cells and accessory cells.

1983 • 93 citations

Immune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex.

1982 • 87 citations

Adaptive differentiation of murine lymphocytes. I. Both T and B lymphocytes differentiating in F1 transplanted to parental chimeras manifest preferential cooperative activity for partner lymphocytes derived from the same parental type corresponding to the chimeric host.

1978 • 84 citations

Prostaglandin E1 inhibits T-cell proliferation and renal disease in mice

1981 • 80 citations

Genetic control of T-cell proliferative responses to poly(glu40ala60) and poly(glu51lys34tyr15): Subregion-specific inhibition of the responses with monoclonal Ia antibodies

1980 • 77 citations

Ir gene function in an I-A subregion mutant B6.C-H-2bm12.

1981 • 76 citations

Increase in macrophage Ia expression in autoimmune mice: role of the Ipr gene.

1982 • 76 citations

Differential glycosylation of murine B cell and spleen adherent cell Ia antigens.

1981 • 74 citations

Mhc RESTRICTION AND Ir GENES

1982 • 73 citations

Concomitant induction of the cell surface expression of Ia determinants and accessory cell function by a murine macrophage tumor cell line.

1982 • 72 citations

Self recognition in allogeneic thymic chimeras. Self recognition by T helper cells from thymus-engrafted nude mice is restricted to the thymic H-2 haplotype.

1982 • 65 citations

Efficiency of antigen presentation differs in mice differing at the Mls locus

1983 • 62 citations

Small subunit of I–A subregion antigens determines the allospecificity recognized by a monoclonal antibody

1980 • 60 citations

T cell clones with dual specificity for M1s and various major histocompatibility complex determinants.

1981 • 60 citations

Generation of F1 hybrid cytotoxic T lymphocytes specific for self H–2

1981 • 59 citations

Expression of I–Ak class II genes in mouse L cells after DNA-mediated gene transfer

1983 • 58 citations

Specificity of T cell clones for antigen and autologous major histocompatibility complex products determines specificity for foreign major histocompatibility complex products.

1983 • 51 citations

Graft-versus-host reaction: a pathogenetic principle for the development of drug allergy, autoimmunity, and malignant lymphoma in non-chimeric individuals. Hypothesis

1976 • 51 citations

The cellular basis for immune interferon production in autoimmune MRL-Ipr/Ipr mice.

1983 • 51 citations

Biosynthesis and expression of Ia and H-2 antigens on a macrophage cell line are stimulated by products of activated spleen cells.

1983 • 48 citations

T cell regulation of b cell activation. Cloned Lyt-1+2-T suppressor cells inhibit the major histocompatibility complex-restricted interaction of T helper cells with B cells and/or accessory cells.

1983 • 46 citations

Subpopulations of B cells distinguished by cell surface expression of Ia antigens. Correlation of Ia and idiotype during activation by cloned Ia-restricted T cells.

1983 • 44 citations

Clones of alloreactive T cells

1980 • 44 citations

MHC recognition by clones of Mls specific T-lymphocytes

1982 • 42 citations

Primary in Vitro Cytotoxic Response of F1 T Lymphocytes against Parental Antigens

1979 • 35 citations

Differential expression of Ia glycoprotein complexes in F1 hybrid mice detected with alloreactive cloned T cell lines.

1982 • 34 citations

Differential macrophage requirements for T helper cell and T helper cell-induced B lymphocyte proliferation.

1983 • 30 citations

The CBA/N defect defines two classes of T cell-dependent antigens.

1981 • 29 citations

Production of anti-self H–2 antibodies by hybrid mice immune to a viral tumour

1981 • 27 citations

Enhancement of the mixed lymphocyte reaction by in vivo treatment of stimulator spleen cells with anti-IgD antibody.

1983 • 24 citations

Inhibition of T cell activation in vivo with mixtures of monoclonal antibodies specific for I-A and I-A/E molecules.

1981 • 23 citations

Regulation of murine T-cell responses to autologous antigens by α-fetoprotein

1981 • 21 citations

Two distinct high immune response phenotypes are both controlled byH-2 genes mapping inK orI-A

1981 • 19 citations

Lysis of inducer T cell clones by activated macrophages and macrophage-like cell lines.

1983 • 18 citations

Major histocompatibility complex-restricted self-recognition in responses to trinitrophenyl-ficoll. Adaptive differentiation and self-recognition by B cells.

1982 • 17 citations

Alterations in the expression of Ia antigens in F1 hybrid mice

1981 • 16 citations

The neutron half-life and cosmology

1979 • 13 citations

Clonal analysis of F1 hybrid helper T cells. I-A subregion-encoded hybrid determinants restrict the activity of keyhole limpet hemocyanin-specific helper T cells.

1981 • 7 citations