Enhanced Activation of T Cells by Dendritic Cells Engineered to Hyperexpress a Triad of Costimulatory Molecules

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Clinical Cancer Research

1941 • 1,358 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

1997 • 860 citations

Regression of human metastatic renal cell carcinoma after vaccination with tumor cell–dendritic cell hybrids

2000 • 652 citations

Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells

1997 • 596 citations

Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responsesin vitroandin vivo

1998 • 457 citations

Exact prediction of a natural T cell epitope

1991 • 455 citations

Generation of Tumor Immunity by Bone Marrow-Derived Dendritic Cells Correlates with Dendritic Cell Maturation Stage

1999 • 430 citations

Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes.

1992 • 395 citations

Compact, Synthetic, Vaccinia Virus Early/Late Promoter for Protein Expression

1997 • 394 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 334 citations

Induction of antitumor immunity using bone marrow-generated dendritic cells.

1996 • 323 citations

Dendritic Cells Retrovirally Transduced with a Model Antigen Gene Are Therapeutically Effective against Established Pulmonary Metastases

1997 • 309 citations

A Phase I study of active immunotherapy with carcinoembryonic antigen peptide (CAP-1)-pulsed, autologous human cultured dendritic cells in patients with metastatic malignancies expressing carcinoembryonic antigen.

1999 • 299 citations

Immunotherapy of cancer with dendritic-cell-based vaccines

1998 • 298 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 294 citations

A triad of costimulatory molecules synergize to amplify T-cell activation.

1999 • 293 citations

Dendritic Cells in Antitumor Immune Responses

1996 • 282 citations

BONE MARROW-DERIVED DENDRITIC CELL PROGENITORS (NLDC 145+, MHC CLASS II+, B7-1dim, B7-2−) INDUCE ALLOANTIGEN-SPECIFIC HYPORESPONSIVENESS IN MURINE T LYMPHOCYTES1,2

1995 • 281 citations

Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.

1995 • 271 citations

Immunotherapy with Dendritic Cells Directed against Tumor Antigens Shared with Normal Host Cells Results in Severe Autoimmune Disease

2000 • 258 citations

Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL.

1997 • 256 citations

Evaluation of phase I/II clinical trials in prostate cancer with dendritic cells and PSMA peptides

1998 • 246 citations

Dendritic cells: a link between innate and adaptive immunity.

1999 • 228 citations

Phase I/IIa Safety, Immunogenicity, and Efficacy Trial of NYVAC‐Pf7, a Pox‐Vectored, Multiantigen, Multistage Vaccine Candidate forPlasmodium falciparumMalaria

1998 • 225 citations

CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation.

1996 • 220 citations

Dendritic Cells in Antitumor Immune Responses

1996 • 219 citations

Retroviral transduction of human dendritic cells with a tumor-associated antigen gene.

1996 • 218 citations

Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL.

1997 • 215 citations

Diversified prime and boost protocols using recombinant vaccinia virus and recombinant non-replicating avian pox virus to enhance T-cell immunity and antitumor responses

1997 • 209 citations

Dendritic cells require maturation via CD40 to generate protective antitumor immunity.

1998 • 204 citations

Vaccination against Chlamydial Genital Tract Infection after Immunization with Dendritic Cells Pulsed Ex Vivo with Nonviable Chlamydiae

1998 • 194 citations

T Cell Activation Pathways: B7, LFA-3, and ICAM-1 Shape Unique T Cell Profiles

1995 • 165 citations

Cutting Edge: Dendritic Cells Require Maturation via CD40 to Generate Protective Antitumor Immunity

1998 • 155 citations

Distinctive nucleotide sequences adjacent to multiple initiation and termination sites of an early vaccinia virus gene

1981 • 149 citations

Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine

1997 • 144 citations

Induction of CD8⁺ cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic cells

1993 • 138 citations

RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes.

1992 • 132 citations

Host Range Restricted, Non-Replicating Vaccinia Virus Vectors as Vaccine Candidates

1996 • 128 citations

Co‐expression of B7‐1 and ICAM‐1 on tumors is required for rejection and the establishment of a memory response

1995 • 116 citations

CTL Response toMycobacterium tuberculosis: Identification of an Immunogenic Epitope in the 19-kDa Lipoprotein

1998 • 116 citations

Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells

1997 • 114 citations

Fowlpox Virus Host Range Restriction: Gene Expression, DNA Replication, and Morphogenesis in Nonpermissive Mammalian Cells

1993 • 113 citations

Experimental vaccine strategies for cancer immunotherapy

1998 • 100 citations

Dendritic cell maturation is required for initiation of the immune response

1997 • 98 citations

Admixture of a recombinant vaccinia virus containing the gene for the costimulatory molecule B7 and a recombinant vaccinia virus containing a tumor-associated antigen gene results in enhanced specific T-cell responses and antitumor immunity.

1995 • 93 citations

Optimization of the sequence of antigen loading and CD40-ligand-induced maturation of dendritic cells.

1998 • 91 citations

Retrovirally Transduced Human Dendritic Cells Express a Normal Phenotype and Potent T-Cell Stimulatory Capacity

1997 • 85 citations

Induction and Measurement of Cytotoxic T Lymphocyte Activity

2018 • 85 citations

Sequence and transcriptional analysis of the vaccinia virus HindIII I fragment

1988 • 80 citations

Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses Using Dendritic Cells Pulsed With EBNA-3A Peptides or UV-Inactivated, Recombinant EBNA-3A Vaccinia Virus

1999 • 78 citations

Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death.

1997 • 69 citations

Gene transfer into human dendritic antigen-presenting cells by vaccinia virus and adenovirus vectors.

1999 • 66 citations

The role of B7-1 and LFA-3 in costimulation of CD8+ T cells

1997 • 63 citations

Formation of Lentivirus Particles by Mammalian Cells Infected with Recombinant Fowlpox Virus

1991 • 56 citations

HIV-1-Specific CTL Responses Primed In Vitro by Blood-Derived Dendritic Cells and Th1-Biasing Cytokines

1999 • 54 citations

Comparative Analysis of Murine Dendritic Cells Derived from Spleen and Bone Marrow

1998 • 48 citations

The role of B7-1 and LFA-3 in costimulation of CD8+ T cells.

1997 • 47 citations

Autoimmune disease induced by dendritic cell immunization against leukemia

1999 • 46 citations

Efficient Retrovirus-Mediated Gene Transfer of Dendritic Cells Generated from CD34⁺Cord Blood Cells under Serum-Free Conditions

1997 • 46 citations

Dendritic Cell Based Therapy of Cancer

1997 • 45 citations

The use of combination vaccinia vaccines and dual-gene vaccinia vaccines to enhance antigen-specific T-cell immunity via T-cell costimulation

1999 • 44 citations

Peptide‐specific activation of cytolytic CD4⁺ T lymphocytes against tumor cells bearing mutated epitopes of K‐ras p21

1995 • 42 citations

Expression of B7 Costimulator Molecules on Mouse Dendritic Cells

1995 • 40 citations

Dendritic Cell-Based Immunotherapy of Renal Cell Carcinoma

1998 • 39 citations