Response of astrocytes and oligodendrocytes to injury

Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes

1991 • 1,171 citations

Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys

1997 • 1,147 citations

Neuronal and Glial Apoptosis after Traumatic Spinal Cord Injury

1997 • 901 citations

Cytokines in inflammatory brain lesions: helpful and harmful

1996 • 727 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion

1993 • 517 citations

CNTF Protection of Oligodendrocytes Against Natural and Tumor Necrosis Factor-Induced Death

1993 • 486 citations

Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells

1996 • 447 citations

Brain glia release factors with opposing actions upon neuronal survival

1993 • 437 citations

Glia are a unique substrate for the in vitro growth of central nervous system neurons

1984 • 425 citations

Astrocytes Block Axonal Regeneration in Mammals by Activating the Physiological Stop Pathway

1987 • 400 citations

Adult rat brain astrocytes support survival of both NGF-dependent and NGF-insensitive neurones

1979 • 378 citations

Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines

1994 • 343 citations

Macrophages can modify the nonpermissive nature of the adult mammalian central nervous system

1990 • 308 citations

Deposition of Scar Tissue in the Central Nervous System

1983 • 285 citations

Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro

1993 • 281 citations

Apoptosis and Expression of Bcl-2 after Compression Trauma to Rat Spinal Cord

1996 • 259 citations

Injury‐induced Regulation of Ciliary Neurotrophic Factor mRNA in the Adult Rat Brain

1993 • 251 citations

Apoptosis-Suppressor Genebcl-2Expression after Traumatic Brain Injury in Rats

1997 • 244 citations

Reactive Gliosis as a Consequence of Interleukin-6 Expression in the Brain: Studies in Transgenic Mice

1994 • 242 citations

Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination.

1992 • 223 citations

The Brain Chondroitin Sulfate Proteoglycan Brevican Associates with Astrocytes Ensheathing Cerebellar Glomeruli and Inhibits Neurite Outgrowth from Granule Neurons

1997 • 223 citations

Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo.

1991 • 217 citations

Transplants of purified astrocytes promote behavioral recovery after frontal cortex ablation

1986 • 208 citations

Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis.

1995 • 207 citations

Neuroglia: Gliosis and Focal Epilepsy

1970 • 206 citations

Postnatally Induced Formation of the Corpus Callosum in Acallosal Mice on Glia-Coated Cellulose Bridges

1983 • 201 citations

The survival of brain transplants is enhanced by extracts from injured brain.

1984 • 185 citations

Targeted CNS Expression of Interferon-γ in Transgenic Mice Leads to Hypomyelination, Reactive Gliosis, and Abnormal Cerebellar Development

1996 • 184 citations

Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor

1991 • 183 citations

Attenuation of Astroglial Reactivity by Interleukin-10

1996 • 182 citations

OVERRIDING THE BRAIN'S INTRINSIC RESISTANCE TO LEUKOCYTE RECRUITMENT WITH INTRAPARENCHYMAL INJECTIONS OF RECOMBINANT CHEMOKINES

1996 • 181 citations

Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury

1995 • 180 citations

Proliferation of mature oligodendrocytes after trauma to the central nervous system

1984 • 179 citations

Induction of a neurite-promoting factor in rat brain following injury or deafferentation

1986 • 166 citations

TNF-α transgenic and knockout models of CNS inflammation and degeneration

1997 • 164 citations

Hematolymphopoietic and inflammatory cytokines in neural development

1997 • 162 citations

Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system.

1992 • 156 citations

Astrogliosis in the Neonatal and Adult Murine Brain Post-Trauma: Elevation of Inflammatory Cytokines and the Lack of Requirement for Endogenous Interferon-γ

1997 • 151 citations

Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin

1994 • 148 citations

In vitro evidence for a dual role of tumor necrosis factor‐α in human immunodeficiency virus type 1 encephalopathy

1995 • 138 citations

Biochemical subtypes of oligodendrocyte in the anterior medullary velum of the rat as revealed by the monoclonal antibody rip

1995 • 133 citations

Effects of neonatal transection on glial cell development in the rat optic nerve: evidence that the oligodendrocyte-type 2 astrocyte cell lineage depends on axons for its survival

1984 • 131 citations

Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo

1995 • 119 citations

A POTENT INHIBITOR OF NEURITE OUTGROWTH THAT PREDOMINATES IN THE EXTRACELLULAR MATRIX OF REACTIVE ASTROCYTES

1996 • 115 citations

Astrocyte-polymer implants promote regeneration of dorsal root fibers into the adult mammalian spinal cord

1990 • 112 citations

The response of the cerebral hemisphere of the rat to injury. II. The neonatal rat

1990 • 112 citations

Differences between adult and neonatal rats in their astroglial response to spinal injury

1984 • 110 citations

CNTF regulation of astrogliosis and the activation of microglia in the developing rat central nervous system

1995 • 110 citations

Early recruitment of oligodendrocyte precursors in CNS demyelination

1994 • 109 citations

Oligodendrocytes in the adult rat spinal cord undergo radiation-induced apoptosis.

1996 • 106 citations

Ciliary Neurotrophic Factor Activates JAK/Stat Signal Transduction Cascade and Induces Transcriptional Expression of Glial Fibrillary Acidic Protein in Glial Cells

1997 • 106 citations

The Pathobiology of the Oligodendrocyte

1997 • 103 citations

Basic fibroblast growth factor (bFGF) injection activates the glial reaction in the injured adult rat brain

1996 • 101 citations

Divergent effects of astroglial and microglial secretions on neuron growth and survival

1992 • 95 citations

Characterization of the signalling pathways involved in ATP and basic fibroblast growth factor‐induced astrogliosis

1997 • 86 citations

Effects of Conditioning Lesions on Transplant Survival, Connectivity, and Function

1987 • 76 citations

Multiple sclerosis. Interactions between oligodendrocytes and hypertrophic astrocytes and their occurrence in other, nondemyelinating conditions.

1992 • 76 citations

Astrocyte transplants alleviate lesion induced memory deficits independently of cholinergic recovery

1995 • 74 citations

Impaired brain development and reduced astrocyte response to injury in transgenic mice expressing IGF binding protein-1

1997 • 73 citations

Preliminary studies of cytokine-induced functional effects on the visual pathways in the rabbit

1989 • 72 citations

Oligodendrocyte survival in Wallerian degeneration

1990 • 72 citations

Astrocytes promote process outgrowth by adult human oligodendrocytes in vitro through interaction between bFGF and astrocyte extracellular matrix

1996 • 70 citations

Astrocytes and catalase prevent the toxicity of catecholamines to oligodendrocytes

1994 • 69 citations

Response of striatal astrocytes to neuronal deafferentation: An immunocytochemical and ultrastructural study

1994 • 68 citations

Astrocyte reactivity in neonatal mice: apparent dependence on the presence of reactive microglia/macrophages

1996 • 64 citations

Type 1 astrocytes inhibit myelination by adult rat oligodendrocytes in vitro

1989 • 61 citations

Regeneration of Injured Axons in the Adult Mammalian Central Nervous System

1997 • 59 citations

Phenotypic Alteration of Astrocytes Induced by Ciliary Neurotrophic Factor in the Intact Adult Brain, As Revealed by Adenovirus-Mediated Gene Transfer

1997 • 58 citations

Myelin basic protein mRNA translocation in oligodendrocytes is inhibited by astrocytes in vitro

1993 • 55 citations

Oligodendrocytes and Myelin

1995 • 45 citations

Age‐dependent decrease of process formation by cultured oligodendrocytes is augmented by protein kinase C stimulation

1991 • 43 citations

The Response of Rubrospinal Neurons to Axotomy at Different Stages of Development in the North American Opossum

1992 • 32 citations

The role of astrocytes in the remyelination of glia-free areas of demyelination.

1993 • 28 citations

Heparan sulfate modifies the effects of basic fibroblast growth factor on glial reactivity

1997 • 7 citations

The effects of interleukin-1 receptor antagonist protein (IRAP) infusion following spinal cord transection in rats

1996 • 7 citations

Protein Kinase C Regulates Process Formation by Oligodendrocytes

1997 • 3 citations

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