Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model

1989 • 1,126 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion

1993 • 517 citations

The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain

1989 • 504 citations

Ischaemic brain damage is still common in fatal non-missile head injury.

1989 • 499 citations

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

1991 • 457 citations

Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations

1989 • 450 citations

Regulation of Nerve Growth Factor (NGF) Synthesis in the Rat Central Nervous System: Comparison between the Effects of Interleukin‐1 and Various Growth Factors in Astrocyte Cultures and in vivo

1990 • 369 citations

Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia

1992 • 336 citations

Synthesis of interleukin 1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction?

1984 • 279 citations

Novel Pharmacologic Therapies in the Treatment of Experimental Traumatic Brain Injury: A Review

1993 • 271 citations

Brain interleukin 1 gene expression induced by peripheral lipopolysaccharide administration

1992 • 217 citations

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

1987 • 180 citations

Involvement of cytokines in acute neurodegeneration in the CNS

1993 • 169 citations

Interleukin-1 augments gamma-aminobutyric acidA receptor function in brain.

1991 • 165 citations

Ventricular fluid interleukin-1 activity in patients with head injury.

1987 • 164 citations

Interleukin-1β depresses calcium currents in CA1 hippocampal neurons at pathophysiological concentrations

1992 • 116 citations

In situ hybridization study of interleukin-1β mRNA induced by kainic acid in the rat brain

1993 • 114 citations

Localization of Interleukin-1 Receptor Antagonist mRNA in Rat Brain

1991 • 109 citations

The role of glutamate antagonists for the treatment of CNS injury.

1992 • 108 citations

Possible involvement of interleukin-1 in ischemic brain edema formation

1992 • 108 citations

Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18h) therapeutic window

1993 • 87 citations

Biochemical and histological alterations induced by fluid percussion brain injury in the rat

1993 • 69 citations

Anti-cytokine strategies.

1992 • 45 citations