Transcription factors as targets for cancer therapy

The Hallmarks of Cancer

2000 • 27,569 citations

Molecular portraits of human breast tumours

2000 • 15,445 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

STATs and Gene Regulation

1997 • 3,927 citations

The Use of Molecular Profiling to Predict Survival after Chemotherapy for Diffuse Large-B-Cell Lymphoma

2002 • 3,769 citations

Oncogenic kinase signalling

2001 • 3,632 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Wnt signaling and cancer

2000 • 3,215 citations

STATs: transcriptional control and biological impact

2002 • 3,050 citations

Stat3 as an Oncogene

1999 • 2,770 citations

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

1999 • 2,076 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

STATs in oncogenesis

2000 • 1,723 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms

1998 • 1,516 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

The Hedgehog and Wnt signalling pathways in cancer

2001 • 1,374 citations

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

2000 • 1,307 citations

A matter of life and death

2002 • 1,251 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

1997 • 1,201 citations

MYC oncogenes and human neoplastic disease

1999 • 1,146 citations

Aberrant rel/nfkb genes and activity in human cancer

1999 • 1,127 citations

Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

2000 • 1,019 citations

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

1995 • 994 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia

1997 • 810 citations

Gene Expression Patterns in Human Liver Cancers

2002 • 810 citations

Signal Transduction and the Control of Gene Expression

2002 • 699 citations

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

2001 • 695 citations

Mechanism-Based Target Identification and Drug Discovery in Cancer Research

2000 • 607 citations

The E2F1–3 transcription factors are essential for cellular proliferation

2001 • 595 citations

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

1998 • 571 citations

Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

2002 • 548 citations

Peptide and Protein Recognition by Designed Molecules

2000 • 530 citations

β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

2001 • 457 citations

Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis

2001 • 455 citations

Diverse Signaling Pathways Activated by Growth Factor Receptors Induce Broadly Overlapping, Rather Than Independent, Sets of Genes

1999 • 450 citations

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

1998 • 449 citations

Transducing Hedgehog: the story so far

1998 • 444 citations

Inhibiting HIV-1 Entry

1999 • 433 citations

Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.

1998 • 419 citations

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.

1996 • 414 citations

Proteolysis of the Hedgehog Signaling Effector Cubitus interruptus Requires Phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1

2002 • 381 citations

STAT signaling in head and neck cancer

2000 • 374 citations

Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning

2001 • 373 citations

Modulation of STAT signaling by STAT-interacting proteins

2000 • 372 citations

The Rel/NF-κB family: friend and foe

2000 • 368 citations

Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells

2000 • 367 citations

β-catenin mutation and overexpression in hepatocellular carcinoma

2001 • 347 citations

Cancer gene therapy: fringe or cutting edge?

2001 • 344 citations

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

2002 • 314 citations

p300 Acts as a Transcriptional Coactivator for Mammalian Notch-1

2001 • 313 citations

Deconstructing Myc: Figure 1.

2001 • 311 citations

Negative regulation of the JAK/STAT pathway

1999 • 288 citations

A new nuclear component of the Wnt signalling pathway

2002 • 287 citations

Jun, the oncoprotein

2001 • 287 citations

Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.

1987 • 279 citations

Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma

2002 • 273 citations

Stat1 Depends on Transcriptional Synergy with Sp1

1995 • 272 citations

Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha

2002 • 266 citations

Gli proteins and Hedgehog signaling: development and cancer

1999 • 249 citations

Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1

2001 • 247 citations

Pygopus, a nuclear PHD-finger protein required for Wingless signaling inDrosophila

2002 • 236 citations

Neoplastic Transformation by Truncated Alleles of Human NOTCH1/TAN1 and NOTCH2

1997 • 234 citations

Antagonists of protein–protein interactions

2000 • 229 citations

Catenins, Wnt signaling and cancer

2000 • 227 citations

Interacting Regions in Stat3 and c-Jun That Participate in Cooperative Transcriptional Activation

1999 • 224 citations

γ-Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of β-catenin

2000 • 223 citations

Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex

2002 • 215 citations

A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1

1999 • 207 citations

Constitutive activation of nuclear factor ?B in hepatocellular carcinoma

2000 • 201 citations

Notch signal transduction: a real Rip and more

2000 • 199 citations

The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)

1997 • 194 citations

Activation of ternary complex factor Elk-1 by stress-activated protein kinases

1995 • 190 citations

Transducing the Hedgehog Signal

2000 • 186 citations

Analysis of expression of nuclear factor κB (NF‐κB) in multiple myeloma: downregulation of NF‐κB induces apoptosis

2001 • 162 citations

Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells

2000 • 158 citations

Ras pathway signals are required for notch-mediated oncogenesis

2000 • 150 citations

Cancer and genomics

2001 • 148 citations

Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells

2000 • 131 citations

Evolutionary specialization of the nuclear targeting apparatus

1997 • 125 citations

A Nuclear Protein Tyrosine Phosphatase TC-PTP Is a Potential Negative Regulator of the PRL-Mediated Signaling Pathway: Dephosphorylation and Deactivation of Signal Transducer and Activator of Transcription 5a and 5b by TC-PTP in Nucleus

2002 • 114 citations

Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma

2001 • 113 citations

Characterization of NF-κB Expression in Hodgkin's Disease: Inhibition of Constitutively Expressed NF-κB Results in Spontaneous Caspase-Independent Apoptosis in Hodgkin and Reed-Sternberg Cells

2001 • 104 citations

Ets-1 messenger RNA expression is a novel marker of poor survival in ovarian carcinoma.

2001 • 93 citations

Replication-selective viruses for cancer therapy

2001 • 87 citations

Cooperation Among Stat1, Glucocorticoid Receptor, and PU.1 in Transcriptional Activation of the High-Affinity Fcγ Receptor I in Monocytes

2000 • 85 citations

Oncogenes and Transcriptional Control

1987 • 82 citations

Inhibitors of Protein Farnesyltransferase as Novel Anticancer Agents

2002 • 73 citations

Molecular diagnosis of lymphoid malignancies by gene expression profiling

2002 • 68 citations

Modulation of protein–protein interactions by synthetic receptors: Design of molecules that disrupt serine protease–proteinaceous inhibitor interaction

2002 • 63 citations

Stepwise Transformation of Rat Embryo Fibroblasts: c-Jun, JunB, or JunD Can Cooperate with Ras for Focus Formation, but a c-Jun-Containing Heterodimer Is Required for Immortalization

1996 • 60 citations

Oncogene-lnitiated Aberrant Signaling Engenders the Metastatic Phenotype: Synergistic Transcription Factor Interactions are Targets for Cancer Therapy

1996 • 55 citations

Cell-Specific Association and Shuttling of IκBα Provides a Mechanism for Nuclear NF-κB in B Lymphocytes

2001 • 47 citations

Notch signaling as a target in multimodality cancer therapy.

2000 • 45 citations

Signaling Networks and Cell Cycle Control

2000 • 35 citations

The diverse role of the ETS family of transcription factors in cancer.

2001 • 34 citations

Regulation of the trans-activation potential of STAT5 through its DNA-binding activity and interactions with heterologous transcription factors

2000 • 34 citations

On the offensive

2002 • 33 citations

A rearranged junD transforms chicken embryo fibroblasts.

1992 • 13 citations

Anthracyclines

2002 • 8 citations

Hormones and cancer: new insights, new challenges

2001 • 6 citations

The Wnt Signal Transduction Pathway

2003 • 2 citations