Antisense cyclin D1 induces apoptosis and tumor shrinkage in human squamous carcinomas.

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo

1991 • 743 citations

Function of a human cyclin gene as an oncogene.

1994 • 471 citations

Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression.

1993 • 393 citations

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group [published erratum appears in Hum Mol Genet 1998 May;7(5):941]

1998 • 387 citations

Cyclin D1 is an essential mediator of apoptotic neuronal cell death.

1996 • 383 citations

Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control.

1998 • 279 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus.

1994 • 247 citations

Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer.

1995 • 238 citations

Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck.

1994 • 237 citations

Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells.

1997 • 227 citations

Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation.

1994 • 219 citations

The retinoblastoma protein as a transcriptional repressor

1993 • 176 citations

Molecular characterization of the retinoblastoma susceptibility gene

1993 • 161 citations

G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.

1997 • 155 citations

Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia.

1996 • 146 citations

Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum.

1998 • 145 citations

Apoptosis and expression of p53 response proteins and cyclin D1 after cortical impact in rat brain

1999 • 143 citations

Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer cells.

1995 • 143 citations

Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?

1999 • 141 citations

Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma.

1997 • 132 citations

Analysis of gene amplification in head‐and‐neck squamous‐cell carcinomas

1991 • 126 citations

Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy.

1997 • 125 citations

Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells

1998 • 123 citations

Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1

1995 • 102 citations

Adenovirus-mediated transfer of a wild-type p53 gene and induction of apoptosis in cervical cancer.

1996 • 99 citations

Perturbation of cell cycle regulators in human cancer.

1996 • 96 citations

Recombinant, Replication-Defective Adenovirus Gene Transfer Vectors Induce Cell Cycle Dysregulation and Inappropriate Expression of Cyclin Proteins

1998 • 74 citations

Frequent rearrangement of chromosomal bands 1p22 and 11q13 in squamous cell carcinomas of the head and neck

1990 • 71 citations

A transgenic mouse model with cyclin D1 overexpression results in cell cycle, epidermal growth factor receptor, and p53 abnormalities.

1997 • 71 citations

Inhibition of lung cancer proliferation by antisense cyclin D.

1996 • 59 citations

Characterization of mutants within the gene for the adenovirus E3 14.7-kilodalton protein which prevents cytolysis by tumor necrosis factor

1993 • 55 citations

Deletion and methylation of the tumour suppressor gene p16/CDKN2 in primary head and neck squamous cell carcinoma.

1997 • 52 citations

Genetic alterations of chromosome band 9p21 – 22 in head and neck cancer are not restricted to p16INK4a

1997 • 51 citations

Cyclin D₁antisense RNA destabilizes pRb and retards lung cancer cell growth

1997 • 45 citations

TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines

1994 • 40 citations

Expression of the retinoblastoma (RB) tumor suppressor gene inhibits tumor cell invasion in vitro.

1996 • 37 citations

Inhibition of Cell Proliferation in Head and Neck Squamous Cell Carcinoma Cell Lines with Antisense Cyclin D1

1998 • 28 citations

p16/CDKN2 alterations and pRb expression in oesophageal squamous carcinoma

1998 • 24 citations

Gene Therapy for Cystic Fibrosis

1995 • 22 citations

Antisense Oligodeoxynucleotides Targeted against Different Regions of CyclinD1 mRNA May Exert Different Inhibitory Effects on Cell Growth and Gene Expression

1996 • 20 citations

Control of Cyclin D1 Expression by Antisense Oligonucleotides in Three Ovarian Cancer Cell Lines

1998 • 17 citations

Accelerated entry into S phase associated with up-regulation of cyclin D1 as a mechanism for granulocyte colony-stimulating factor (G-CSF)-induced apoptosis of murine myeloid leukemia cells

1998 • 11 citations