Cyclic-3′,5′-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney

Adenosine 3‘,5‘-Phosphate in Biological Materials

1962 • 2,102 citations

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1995 • 1,780 citations

Ultrasensitivity in the mitogen-activated protein kinase cascade.

1996 • 1,200 citations

Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.

1996 • 1,070 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

The Kidney: Physiology and Pathophysiology.

1985 • 665 citations

Sildenafil, a novel effective oral therapy for male erectile dysfunction

1996 • 566 citations

Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes

1991 • 468 citations

Tailoring cAMP-signalling responses through isoform multiplicity

1997 • 437 citations

Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3)

1997 • 418 citations

Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase

1996 • 406 citations

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

1995 • 345 citations

Isolation and Characterization of PDE9A, a Novel Human cGMP-specific Phosphodiesterase

1998 • 332 citations

Recent Progress in Understanding the Hormonal Regulation of Phosphodiesterases

1995 • 313 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

Identification and Characterization of a Novel Family of Cyclic Nucleotide Phosphodiesterases

1998 • 283 citations

A standard nomenclature for structures of the kidney. The Renal Commission of the International Union of Physiological Sciences (IUPS).

1988 • 282 citations

Cytokine production by epithelial cells ¹

1994 • 273 citations

Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase

1998 • 269 citations

Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry and function

1991 • 250 citations

Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?

1997 • 232 citations

The glomerular response to injury: Progression or resolution?

1994 • 230 citations

Diversity in Cyclic Nucleotide Phosphodiesterase Isoenzyme Families

1995 • 228 citations

Isolation and Characterization of PDE8A, a Novel Human cAMP-Specific Phosphodiesterase

1998 • 224 citations

The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells

1993 • 222 citations

Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae

1993 • 219 citations

High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells.

1991 • 218 citations

Type 4 Phosphodiesterase Inhibitors Have Clinical and In Vitro Anti-inflammatory Effects in Atopic Dermatitis

1996 • 217 citations

Negative Regulation of Raf-1 by Phosphorylation of Serine 621

1996 • 215 citations

The nitric oxide/cyclic GMP pathway in organ transplantation: critical role in successful lung preservation.

1994 • 190 citations

Role of phosphodiesterases in the regulation of endothelial permeability in vitro.

1993 • 189 citations

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

1997 • 186 citations

Proposal for Pharmacologically Distinct Conformers of PDE4 Cyclic AMP Phosphodiesterases

1997 • 185 citations

The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation.

1994 • 183 citations

Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor.

1995 • 178 citations

Cyclic nucleotide phosphodiesterases: Structure, regulation and drug action

1991 • 176 citations

Multiple intracellular MAP kinase signaling cascades

1996 • 173 citations

Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases.

1995 • 164 citations

Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP.

1990 • 161 citations

Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition

1996 • 161 citations

The Calmodulin-dependent Phosphodiesterase Gene PDE1C Encodes Several Functionally Different Splice Variants in a Tissue-specific Manner

1996 • 157 citations

Zinc interactions and conserved motifs of the cGMP-binding cGMP-specific phosphodiesterase suggest that it is a zinc hydrolase.

1994 • 155 citations

Effects of atrial natriuretic factor on cyclic guanosine monophosphate and cyclic adenosine monophosphate accumulation in microdissected nephron segments from rats.

1987 • 144 citations

Pathogenesis of nephrogenic diabetes insipidus due to chronic administration of lithium in rats.

1985 • 142 citations

The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP.

1989 • 142 citations

Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3′,5′-cyclic nucleotide phosphodiesterase

1997 • 138 citations

Identification and properties of cyclic nucleotide phosphodiesterases

1982 • 135 citations

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1993 • 133 citations

Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype.

1997 • 132 citations

Pharmacology of nootropics and metabolically active compounds in relation to their use in dementia

1990 • 132 citations

Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell.

1991 • 130 citations

Renal accumulation and excretion of cyclic adenosine monophosphate in a murine model of slowly progressive polycystic kidney disease

1997 • 129 citations

Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.

1995 • 129 citations

Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants

1996 • 128 citations

Targeting signal transduction for disease therapy

1996 • 127 citations

Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3.

1995 • 127 citations

Anti-inflammatory activity of phosphodiesterase (PDE)-IV inhibitors in acute and chronic models of inflammation

1995 • 126 citations

Characterization of cyclic nucleotide phosphodiesterases from cultured bovine aortic endothelial cells

1990 • 126 citations

Expression of a calmodulin-dependent phosphodiesterase isoform (PDE1B1) correlates with brain regions having extensive dopaminergic innervation

1994 • 125 citations

Cytoprotective effects of adrenomedullin in glomerular cell injury: Central role of cAMP signaling pathway

1997 • 124 citations

Distribution of Hormone-Dependent Adenylate Cyclase in the Nephron and its Physiological Significance

1981 • 122 citations

cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes.

1997 • 121 citations

Interactions between the components of the human nadph oxidase: intrigues in the phox family

1996 • 121 citations

Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant

1997 • 115 citations

Alternative Splicing of the High Affinity cAMP-Specific Phosphodiesterase (PDE7A) mRNA in Human Skeletal Muscle and Heart

1997 • 110 citations

Milrinone: Basic and Clinical Pharmacology and Acute and Chronic Management

1996 • 108 citations

cGMP: The wayward child of the cyclic nucleotide family

1991 • 103 citations

Dual mechanism of angiotensin II inhibits ANP-induced mesangial cGMP accumulation

1991 • 102 citations

Stimulation of renin secretion by nitric oxide is mediated by phosphodiesterase 3

1998 • 102 citations

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

1997 • 101 citations

The Human Cyclic AMP-specific Phosphodiesterase PDE-46 (HSPDE4A4B) Expressed in Transfected COS7 Cells Occurs as Both Particulate and Cytosolic Species That Exhibit Distinct Kinetics of Inhibition by the Antidepressant Rolipram

1996 • 99 citations

The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5)

1996 • 99 citations

Zardaverine as a selective inhibitor of phosphodiesterase isozymes

1991 • 97 citations

Precision Substrate Targeting of Protein Kinases

1996 • 97 citations

Could isoenzyme-selective phosphodiesterase inhibitors render bronchodilator therapy redundant in the treatment of bronchial asthma?

1992 • 97 citations

Differential inhibition of human neutrophil functions

1990 • 95 citations

Efficacy and Tolerance of Vinpocetine in Ambulant Patients Suffering from Mild to Moderate Organic Psychosyndromes

1991 • 94 citations

Is Phosphodiesterase inhibition a new mechanism of antidepressant action?

1988 • 93 citations

Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

1995 • 93 citations

Salbutamol Up-regulates PDE4 Activity and Induces a Heterologous Desensitization of U937 Cells to Prostaglandin E2

1995 • 92 citations

Role of cyclic nucleotides in cancer.

1974 • 91 citations

Phosphodiesterases from porcine coronary arteries: inhibition of separated forms by xanthines, papaverine, and cyclic nucleotides.

1975 • 91 citations

Cellular distribution of phosphodiesterase isoforms in rat cardiac tissue.

1991 • 90 citations

Cellular basis for blunted volume expansion natriuresis in experimental nephrotic syndrome.

1992 • 90 citations

Monocyte Phosphodiesterase Abnormalities and Dysregulation of Lymphocyte Function in Atopic Dermatitis

1995 • 89 citations

M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs

1993 • 88 citations

Blunted cGMP response to agonists and enhanced glomerular cyclic 3′,5′-nucleotide phosphodiesterase activities in experimental congestive heart failure

1996 • 86 citations

Involvement of cyclic nucleotide‐dependent protein kinases in cyclic AMP‐mediated vasorelaxation

1997 • 85 citations

Cyclic nucleotide phosphodiesterase isoenzyme activities in human alveolar macrophages

1995 • 85 citations

CYCLIC AMP AND HORMONE ACTION

1972 • 84 citations

Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: effects on platelet aggregation

1997 • 82 citations

Restoration of the cAMP second messenger pathway enhances cardiac preservation for transplantation in a heterotopic rat model.

1993 • 81 citations

Purification and characterization of high-affinity cyclic adenosine monophosphate phosphodiesterase from dog kidney

1979 • 81 citations

Atrial Natriuretic Peptide Induces the Expression of MKP-1, a Mitogen-activated Protein Kinase Phosphatase, in Glomerular Mesangial Cells

1996 • 79 citations

Activation of extracellular signal-regulated kinase in proliferative glomerulonephritis in rats.

1997 • 79 citations

Regulation and function of cyclic nucleotides

1992 • 78 citations

Adenine nucleotide diphosphates: emerging second messengers acting via intracellular Ca2+ release

1996 • 78 citations

Cyclic GMP and Regulation of Cyclic Nucleotide Hydrolysis

1994 • 76 citations

Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV.

1996 • 75 citations

Hypoxia-induced modulation of endothelial cell properties: Regulation of barrier function and expression of interleukin-6

1997 • 74 citations

Phosphodiesterase 4 and tolerance to beta 2-adrenoceptor agonists in asthma.

1996 • 73 citations

A Novel Cyclic GMP Stimulated Phosphodiesterase from Rat Brain

1994 • 73 citations

Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase

1995 • 72 citations

Phosphodiesterase 4 and tolerance to β2-adrenoceptor agonists in asthma

1996 • 72 citations

ADH-sensitive cAMP system in papillary collecting duct: effect of osmolality and PGE2

1981 • 71 citations

Inhibitors of cyclic nucleotide phosphodiesterase isozymes type-III and type-IV suppress mitogenesis of rat mesangial cells.

1995 • 70 citations

Hypoxia and modification of the endothelium: implications for regulation of vascular homeostatic properties

1995 • 70 citations

Treatment of virus-induced myocardial injury with a novel immunomodulating agent, vesnarinone. Suppression of natural killer cell activity and tumor necrosis factor-alpha production.

1994 • 69 citations

Alkaline phosphatase in adaptation to low dietary phosphate intake.

1979 • 69 citations

A selective type V phosphodiesterase inhibitor, E4021, dilates porcine large coronary artery.

1995 • 68 citations

Pig aortic endothelial-cell cyclic nucleotide phosphodiesterases. Use of phosphodiesterase inhibitors to evaluate their roles in regulating cyclic nucleotide levels in intact cells

1990 • 68 citations

Growth-regulatory properties of atrial natriuretic factor

1992 • 68 citations

Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes

1998 • 67 citations

cAMP-Mediated Vascular Protection in an Orthotopic Rat Lung Transplant Model

1996 • 65 citations

Effect of Cilostazol in Preventing Restenosis After Percutaneous Transluminal Coronary Angioplasty

1997 • 64 citations

Compartmentalization of cAMP Signaling in Mesangial Cells by Phosphodiesterase Isozymes PDE3 and PDE4 REGULATION OF SUPEROXIDATION AND MITOGENESIS

1997 • 63 citations

Determination of the Structure of the N-terminal Splice Region of the Cyclic AMP-specific Phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and Identification of the Membrane Association Domain Using Chimeric Constructs

1996 • 63 citations

Selective Activation of Rolipram-Sensitive, cAMP-Specific Phosphodiesterase Isoforms by Phosphatidic Acid

1997 • 63 citations

Requirement of the SH3 and SH2 Domains for the Inhibitory Function of Tyrosine Protein Kinase p50^csk in T Lymphocytes

1995 • 62 citations

Resolution of soluble cyclic nucleotide phosphodiesterase isoenzymes, from liver and hepatocytes, identifies a novel IBMX-insensitive form

1989 • 62 citations

Antiplatelet and Antiproliferative Effects of SCH 51866, a Novel Type 1 and Type 5 Phosphodiesterase Inhibitor

1996 • 61 citations

Amelioration of collagen II-induced arthritis in rats by the type IV phosphodiesterase inhibitor Rolipram

1997 • 61 citations

A standard nomenclature for structures of the kidney

1988 • 61 citations

The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages

1993 • 61 citations

The mechanisms of insulin action

1987 • 60 citations

Characterization of a novel potent and specific inhibitor of type v phosphodiesterase

1995 • 60 citations

Phosphodiesterase isozyme inhibition and the potentiation by zaprinast of endothelium-derived relaxing factor and guanylate cyclase stimulating agents in vascular smooth muscle.

1989 • 60 citations

Characterization of cyclic nucleotide phosphodiesterases with cyclic GMP analogs: topology of the catalytic domains.

1995 • 58 citations

Phosphodiesterase inhibition improves agonist-induced relaxation of hypertensive pulmonary arteries.

1997 • 57 citations

Phosphodiesterase Inhibitors

1996 • 55 citations

Milrinone: Basic and Clinical Pharmacology and Acute and Chronic Management

1996 • 55 citations

Selective Effects of Phosphodiesterase Inhibitors on Different Phosphodiesterases, Adenosine 3′,5′-Monophosphate Metabolism, and Lipolysis in 3T3-L1 Adipocytes

1984 • 54 citations

Differential inhibition of mesangial MAP kinase cascade by cyclic nucleotides

1996 • 53 citations

Phosphorylation of a cAMP-specific phosphodiesterase (HSPDE4B2B) by mitogen-activated protein kinase

1996 • 53 citations

A New Cyclic Nucleotide Phosphodiesterase Isozyme Expressed in the T-Lymphocyte Cell Lines

1993 • 52 citations

Platelet Activation: New Aspects

1996 • 51 citations

Light emission by isolated rat glomeruli in response to phorbol myristate acetate.

1981 • 51 citations

Cellular Action of Vasopressin in Medullary Tubules of Mice with Hereditary Nephrogenic Diabetes Insipidus

1980 • 50 citations

1 Phosphodiesterase Type IV Inhibitors

1996 • 46 citations

Localization of mRNAs coding for isozymes of plasma membrane Ca(2+)-ATPase pump in rat kidney

1992 • 46 citations

Purification, characterization and analysis of rolipram inhibition of a human type-IVA cyclic AMP-specific phosphodiesterase expressed in yeast

1994 • 45 citations

Antidepressant effects of rolipram in a genetic animal model of depression: Cholinergic supersensitivity and weight gain

1989 • 43 citations

Zaprinast accelerates recovery from established acute renal failure in the rat

1995 • 42 citations

Stimulation of cyclic adenosine monophosphate formation by the novel vasorelaxant peptide adrenomedullin in cultured rat mesangial cells

1995 • 42 citations

Tissue distribution and selective inhibition of subtypes of high affinity cAMP phosphodiesterase

1988 • 42 citations

Receptors for atrial natriuretic peptide are decreased in the kidney of rats with streptozotocin-induced diabetes mellitus.

1995 • 41 citations

Use of Cilostazol, a Novel Antiplatelet Agent, in a Post-Palmaz-Schatz Stenting Regimen

1997 • 41 citations

Phosphodiesterase inhibitors correct resistance to natriuretic peptides in rats with Heymann Nephritis.

1996 • 40 citations

Analysis of PDE Isoenzyme Profiles in Cells and Tissues by Pharmacological Methods

1996 • 39 citations

Inhibition of type IV phosphodiesterase by Ro 20-1724 attenuates endotoxin-induced acute renal failure.

1996 • 39 citations

Formation of reactive oxygen metabolites in glomeruli is suppressed by inhibition of cAMP phosphodiesterase isozyme type IV

1994 • 39 citations

Electron microscopic immunocytochemical evidence that the calmodulin-dependent cyclic nucleotide phosphodiesterase is localized predominantly at postsynaptic sites in the rat brain

1991 • 38 citations

Inhibitors of cyclic nucleotide phosphodiesterase isozymes block renal tubular cell proliferation induced by folic acid

1997 • 37 citations

Effects of calcium on the vasopressin-sensitive cAMP metabolism in medullary tubules

1985 • 36 citations

Monocyte Phosphodiesterase Abnormalities and Dysregulation of Lymphoctye Function in Atopic Dermatitis.

1995 • 36 citations

Coupling signalling pathways to transcriptional control: nuclear factors responsive to cAMP.

1997 • 36 citations

Compartmentalization of cyclic AMP phosphodiesterases, signalling ‘crosstalk’, desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP

1995 • 35 citations

Elevation of cAMP is required for down-regulation, but not agonist-induced desensitization, of endogenous dopamine D1 receptors in opossum kidney cells. Studies in cells that stably express a rat cAMP phosphodiesterase (rPDE3) cDNA

1993 • 34 citations

Concentrating defect in the adrenalectomized rat. Abnormal vasopressin-sensitive cyclic adenosine monophosphate metabolism in the papillary collecting duct.

1983 • 34 citations

Identification and Quantification of PDE Isoenzymes and Subtypes by Molecular Biological Methods

1996 • 33 citations

Phosphodiesterase activity as a mediator of renal resistance to ANP in pathological salt retention

1996 • 29 citations

Cellular Action of Antidiuretic Hormone in Mice with Inherited Vasopressin-Resistant Urinary Concentrating Defects

1974 • 27 citations

The metabolism of adenosine 3′,5′-cyclic phosphate. II. Some properties of adenosine-3′,5′-cyclic-phosphate phosphodiesterase from the rat kidney

1970 • 27 citations

Calcium-calmodulin-stimulated and cyclic-GMP-specific phosphodiesterases. Tissue distribution, drug sensitivity, and regulation of cyclic GMP levels.

1992 • 26 citations

Cyclic 3',5'-nucleotide diesterases in dynamics of cAMP and cGMP in rat collecting duct cells

1992 • 25 citations

Mechanisms contributing to renal resistance to atrial natriuretic peptide in rats with common bile-duct ligation.

1996 • 24 citations

Cyclic nucleotide phosphodiesterases in glomeruli of rat renal cortex

1978 • 24 citations

Adenyl cyclase and adenosine 3', 5'-cyclic phosphate phosphodiesterase in the receptor tissues of neurohypophysial hormones

1968 • 24 citations

Ginsenosides are potent and selective inhibitors of some calmodulin-dependent phosphodiesterase isozymes

1993 • 24 citations

Chlorpropamide action on renal concentrating mechanism in rats with hypothalamic diabetes insipidus.

1983 • 24 citations

Treatment with the type IV phosphodiesterase inhibitor Ro 20-1724 protects renal and mesenteric blood flow in endotoxemic rats treated with norepinephrine.

1996 • 23 citations

Two Isoforms of cGMP-Inhibited Cyclic Nucleotide Phosphodiesterases in Human Tissues Distinguished by Their Responses to Vesnarinone, a New Cardiotonic Agent

1993 • 23 citations

Measurements of cyclic AMP and cyclic GMP phosphodiesterase activity in isolated tubular segments

1980 • 22 citations

Potential role of cyclic nucleotides in glomerular pathophysiology.

1980 • 22 citations

High Activity of Low-Michaelis-Menten Constant 3′,5′-Cyclic Adenosine Monophosphate-Phosphodiesterase Isozymes in Renal Inner Medulla of Mice With Hereditary Nephrogenic Diabetes Insipidus*

1991 • 22 citations

Oxidant Mechanisms in Glomerulonephritis

1991 • 22 citations

A selective type V phosphodiesterase inhibitor, E4021, protects the development of right ventricular overload and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension

1996 • 22 citations

The N-terminal alternately spliced regions of PDE4A cAMP-specific phosphodiesterases determine intracellular targeting and regulation of catalytic activity

1996 • 22 citations

CELL PROLIFERATION IN THE RAT KIDNEY INDUCED BY FOLIC ACID

1968 • 21 citations

Interaction of the catalytic subunit of protein kinase A with the lung type V cyclic GMP phosphodiesterase: Modulation of non-catalytic binding sites

1992 • 20 citations

Stimulation of renin secretion by the phosphodiesterase IV inhibitor rolipram.

1996 • 19 citations

Induction of intramembranous particle clusters in mice with nephrogenic diabetes insipidus

1991 • 19 citations

cGMP-Inhibited Phosphodiesterases (PDE3)

1996 • 19 citations

Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase

1997 • 18 citations

Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase

1997 • 17 citations

Protein kinase C modulates cAMP content in proximal tubular cells: role of phosphodiesterase inhibition

1991 • 17 citations

Chapter 8. Chronic Pulmonary Inflammation and Other Therapeutic Applications of PDE IV Inhibitors

1996 • 16 citations

Effect of potassium depletion on the vasopressin-sensitive cyclic AMP system in rat outer medullary tubules.

1982 • 16 citations

Formation and Metabolism of Cyclic AMP

1971 • 16 citations

Signaling role of PDE isozymes in pathobiology of glomerular mesangial cells

1998 • 16 citations

Isozymes of cyclic-3′,5′-nucleotide phosphodiesterases in renal epithelial LLC-PK1 cells

1992 • 15 citations

Pharmacologic treatment of congestive heart failure

1996 • 14 citations

Buchbesprechung

1991 • 14 citations

Enzymatic and Functional Aspects of Dual-selective PDE3/4 Inhibitors

1996 • 13 citations

Effects of Theophylline and Non-selective Xanthine Derivatives on PDE Isoenzymes and Cellular Function

1996 • 13 citations

Cyclic AMP turnover in intact tissue. Role of cyclic nucleotide phosphodiesterases.

1992 • 12 citations

Relaxation of human isolated pulmonary arteries by amrinone.

1996 • 12 citations

Cyclic-3',5'-nucleotide phosphodiesterases in the cyclic adenosine monophosphate (cAMP)-mediated actions of vasopressin.

1994 • 11 citations

Ca2+/Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase (PDE1)

1996 • 11 citations

Unilateral ureteral obstruction increases glomerular soluble guanylyl cyclase activity.

1995 • 11 citations

Antagonists of cyclic nucleotide phosphodiesterase (PDE) isozymes PDE 3 and PDE 4 suppress lymphoblastic response to HLA class II alloantigens: a potential novel approach to preventing allograft rejection?

1997 • 11 citations

An Isoform-selective Inhibitor of Cyclic AMP-Specific Phosphodiesterase (PDE4) with Anti-inflammatory Properties

1996 • 10 citations

Prolongation of Murine Cardiac Allograft Survival with Vesnarinone

1997 • 10 citations

A comparison of cyclic AMP signaling system in rat aortic myocytes in primary culture and aorta.

1989 • 9 citations

Activation of protein kinase C stimulates cAMP phosphodiesterase in rat renal collecting tubule

1995 • 9 citations

ADH resistance of LLC-PK1 cells caused by overexpression of cAMP-phosphodiesterase type-IV

1993 • 9 citations

Inhibition of cGMP-Phosphodiesterase Restores the Glomerular Effects of Atrial Natriuretic Factor in Low Sodium Diet Rats

1995 • 8 citations

Inhibition of Phosphodiesterase Isoenzymes and Cell Function by Selective PDE5 Inhibitors

1996 • 8 citations

Modulation by low sodium intake of glomerular response to cicletanine and atrial natriuretic factor

1997 • 7 citations

Phosphodiesterase inhibitors as antiplatelet agents in vascular surgery.

1992 • 7 citations

Hereditary Vasopressin Resistance in Man and Mouse

1993 • 7 citations

ATP and cAMP system in the in vitro response of microdissected cortical tubules to PTH

1985 • 7 citations

Abnormal glomerular response to atrial natriuretic peptide in rats with aortocaval fistulas.

1996 • 5 citations

Cyclic nucleotide phosphodiesterase isozymes in rat mesangial cells

1995 • 4 citations

EHNA as an Inhibitor of PDE2: A Pharmacological and Biochemical Study in Cardiac Myocytes

1996 • 3 citations

Suprasellar Germinoma Associated with Cushing’s Disease and Diabetes insipidus in a Child

1998 • 3 citations

Immunocytochemical Characterization and Identification of SGE1 a Rat Glomerular Epithelial Cell Line

1994 • 2 citations

Effect of Phosphate Deprivation on Enzymes of the Cyclic Adenosine Monophosphate Metabolism in Rat Proximal Convoluted and Proximal Straight Tubules

1990 • 1 citations