Characterization of a novel potent and specific inhibitor of type v phosphodiesterase

Advances in Cyclic Nucleotide Research.

1980 • 1,465 citations

Cyclic GMP synthesis and function.

1987 • 871 citations

Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation

1983 • 623 citations

Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes

1991 • 468 citations

Comparison of vascular smooth muscle cells from adult human, monkey and rabbit in primary culture and in subculture

1977 • 387 citations

Atrial natriuretic factor receptors and signal transduction mechanisms.

1993 • 362 citations

Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.

1990 • 354 citations

Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta

1986 • 301 citations

A Family of Human Phosphodiesterases Homologous to the Dunce Learning and Memory Gene Product of Drosophila melanogaster are Potential Targets for Antidepressant Drugs

1993 • 287 citations

Cyclic GMP and mechanisms of vasodilation

1989 • 260 citations

Increase in cytosolic calcium and phosphoinositide metabolism induced by angiotensin II and [Arg]vasopressin in vascular smooth muscle cells.

1985 • 252 citations

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

1993 • 233 citations

Characterization of a novel cGMP binding protein from rat lung.

1980 • 179 citations

Purifieation of a Soluble, Sodium‐Nitroprusside‐Stimulated Guanylate Cyclase from Bovine Lung

1981 • 147 citations

Guanylate Cyclase, a Cell Surface Receptor

1989 • 146 citations

Haem-dependent activation of cytosolic guanylate cyclase by nitric oxide: a widespread signal transduction mechanism

1992 • 140 citations

Atrial Natriuretic Factor-induced Egression of Cyclic Guanosine 3′:5′-Monophosphate in Cultured Vascular Smooth Muscle and Endothelial Cells

1989 • 139 citations

Cyclic nucleotide phosphodiesterase activities of pig coronary arteries

1975 • 137 citations

Characterization of cyclic nucleotide phosphodiesterases from cultured bovine aortic endothelial cells

1990 • 126 citations

Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation.

1979 • 102 citations

Endothelium-derived nitric oxide: the endogenous nitrovasodilator in the human cardiovascular system

1991 • 91 citations

Cyclic GMP in cell function.

1988 • 89 citations

Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY‐5445, vinpocetine and 1‐methyl‐3‐isobutyl‐8‐(methylamino)xanthine

1989 • 80 citations

The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung

1992 • 78 citations

Cyclic GMP and Regulation of Cyclic Nucleotide Hydrolysis

1994 • 76 citations

Characteristics of a new binding protein distinct from the kinase for guanosine 3′:5′-monophosphate in rat platelets

1980 • 67 citations

The quantitative relationship between intracellular concentration and egress of cyclic AMP from cultured cells.

1981 • 65 citations

Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP.

1984 • 61 citations

Phosphodiesterase isozyme inhibition and the potentiation by zaprinast of endothelium-derived relaxing factor and guanylate cyclase stimulating agents in vascular smooth muscle.

1989 • 60 citations

Effects of phosphodiesterase inhibitors on cyclic nucleotide levels and relaxation of pig coronary arteries.

1979 • 55 citations

Antiallergic activity of 2-phenyl-8-azapurin-6-ones

1975 • 52 citations

Isolation of cyclic nucleotide phosphodiesterase isozymes from pig aorta

1993 • 47 citations

Cyclic AMP efflux is regulated by occupancy of the adenosine receptor in pig aortic smooth muscle cells.

1990 • 43 citations

Cyclic GMP efflux from liver slices.

1983 • 38 citations

Inhibition of Egress of Adenosine 3', 5'-Monophosphate from Pigeon Erythrocytes

1974 • 36 citations

Characterisation of cyclic nucleotide phosphodiesterases from rat mesenteric artery

1991 • 35 citations

Depressor and natriuretic effects of M&B 22,948, a guanosine cyclic 3',5'-monophosphate-selective phosphodiesterase inhibitor.

1989 • 32 citations

[8] cAMP export and its regulation by prostaglandin A1

1988 • 31 citations

In vitro and in vivo interactions of nitrovasodilators and zaprinast, a cGMP-selective phosphodiesterase inhibitor

1992 • 31 citations

Effects of selective phosphodiesterase inhibitors on isolated coronary, lung and renal arteries from man and rat

1991 • 28 citations

Effects of Amrinone and Enoximone on the Subclasses of Cyclic AMP Phosphodiesterase from Human Heart and Kidney

1990 • 25 citations

Correlation between inhibition of a cyclic GMP phosphodiesterase and relaxation of canine tracheal smooth muscle

1985 • 24 citations

Desensitization of atriopeptin stimulated accumulation and extrusion of cyclic GMP from a kidney epithelial cell line (MDCK)

1991 • 20 citations

Inhibition of fibroblast cyclic AMP escape and cyclic nucleotide phosphodiesterase activities by xanthines.

1980 • 11 citations

The turnover of cyclic AMP in cultured fibroblasts.

1980 • 11 citations