Compartmentalization of cyclic AMP phosphodiesterases, signalling ‘crosstalk’, desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP

Activation of two signal-transduction systems in hepatocytes by glucagon

1986 • 383 citations

‘Crosstalk’: a pivotal role for protein kinase C in modulating relationships between signal transduction pathways

1991 • 328 citations

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

1987 • 232 citations

Type-specific stimulation of adenylylcyclase by protein kinase C.

1993 • 187 citations

Molecular diversity in the adenylylcyclase family. Evidence for eight forms of the enzyme and cloning of type VI.

1992 • 159 citations

Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins.

1988 • 156 citations

Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes

1983 • 156 citations

Insulin triggers cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase

1980 • 149 citations

Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: A diverse family of regulatory enzymes

1994 • 135 citations

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1993 • 133 citations

Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase.

1990 • 133 citations

Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase.

1994 • 127 citations

Hormonal regulation of Gi2 α-subunit phosphorylation in intact hepatocytes

1990 • 117 citations

Inhibition of cloned adenylyl cyclases by mutant-activated Gi-alpha and specific suppression of type 2 adenylyl cyclase inhibition by phorbol ester treatment

1993 • 108 citations

Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes

1990 • 95 citations

Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein G_i

1989 • 93 citations

Identification of two splice variant forms of type-IVB cyclic AMP phosphodiesterase, DPD (rPDE-IVB1) and PDE-4 (rPDE-IVB2) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions

1994 • 88 citations

Insulin, glucagon and the receptor-mediated control of cyclic AMP concentrations in liver

1986 • 84 citations

The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism

1987 • 81 citations

Challenge of hepatocytes by glucagon triggers a rapid modulation of adenylate cyclase activity in isolated membranes

1983 • 81 citations

Identification and characterization of both the cytosolic and particulate forms of cyclic GMP-stimulated cyclic AMP phosphodiesterase from rat liver

1986 • 73 citations

The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes

1986 • 69 citations

Vasopressin in Rats With Genetic and Streptozocin-Induced Diabetes

1989 • 66 citations

Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (Gi) on adipocyte adenylate cyclase activity

1990 • 64 citations

Resolution of soluble cyclic nucleotide phosphodiesterase isoenzymes, from liver and hepatocytes, identifies a novel IBMX-insensitive form

1989 • 62 citations

Characterization of the phosphorylated form of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes

1981 • 61 citations

Diabetes induces selective alterations in the expression of protein kinase C isoforms in hepatocytes

1993 • 61 citations

Islet-activating protein blocks glucagon desensitization in intact hepatocytes

1984 • 59 citations

Guanosine 5′-triphosphate and guanosine 5′-[βγ-imido]triphosphate effect a collision coupling mechanism between the glucagon receptor and catalytic unit of adenylate cyclase

1980 • 57 citations

Molecular cloninc and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)

1994 • 46 citations

Altered G-protein expression and adenylate cyclase activity in platelets of non-insulin-dependent diabetic (NIDDM) male subjects

1991 • 45 citations

Purification, characterization and analysis of rolipram inhibition of a human type-IVA cyclic AMP-specific phosphodiesterase expressed in yeast

1994 • 45 citations

A cDNA Construct Allowing the Expression of Rat Hepatic Glucagon Receptors

1993 • 42 citations

Diabetes‐induced changes in guanine‐nucleotide‐regulatory‐protein mRNA detected using synthetic oligonucleotide probes

1990 • 41 citations

Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein Gi2

1991 • 41 citations

Activation and phosphorylation of the ‘dense-vesicle’ high-affinity cyclic AMP phosphodiesterase by cyclic AMP-dependent protein kinase

1989 • 41 citations

Glucagon, vasopressin and angiotensin all elicit a rapid, transient increase in hepatocyte protein kinase C activity

1992 • 39 citations

An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations

1984 • 37 citations

Changes in the phosphorylation state of the inhibitory guanine‐nucleotide‐binding protein G_i‐2 in hepatocytes from lean (Fa/Fa) and obese (fa/fa) Zucker rats

1990 • 35 citations

Alterations in G-protein expression and the hormonal regulation of adenylate cyclase in the adipocytes of obese (fa/fa) Zucker rats

1991 • 32 citations

The use of selective inhibitors and computer modelling to evaluate the role of specific high affinity cyclic AMP phosphodiesterases in the hormonal regulation of hepatocyte intracellular cyclic AMP concentrations

1990 • 31 citations

Gi-2 at the centre of an active phosphorylation/dephosphorylation cycle in hepatocytes: The fine-tuning of stimulatory and inhibitory inputs into adenylate cyclase in normal and diabetic states

1991 • 30 citations

Evidence of cyclic AMP-independent action of glucagon on calcium mobilization in rat hepatocytes

1988 • 30 citations

Phosphorylation of calmodulin on Tyr99 selectively attenuates the action of calmodulin antagonists on type-I cyclic nucleotide phosphodiesterase activity.

1994 • 28 citations

Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity

1992 • 28 citations

Subcellular localization and hormone sensitivity of adipocyte cyclic AMP phosphodiesterase

1989 • 22 citations

Genetically acquired diabetes: adipocyte guanine nucleotide regulatory protein expression and adenylate cyclase regulation

1991 • 21 citations

Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon

1989 • 21 citations

Insulin activates the plasma-membrane and dense-vesicle cyclic AMP phosphodiesterase in hepatocytes by distinct routes

1983 • 19 citations

Vasopressin in rats with genetic and streptozocin-induced diabetes

1989 • 19 citations

Multi-site phosphorylation of the inhibitory guanine nucleotide regulatory protein Gi-2 occurs in intact rat hepatocytes

1994 • 19 citations

Glucagon stimulates adenylate cyclase through GR2 glucagon receptors: a process which can be attenuated by glucagon stimulating inositol phospholipid metabolism through GR1 glucagon receptors

1987 • 16 citations

Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values

1988 • 15 citations

Determination of G-protein levels, ADP-ribosylation by cholera and pertussis toxins and the regulation of adenylyl cyclase activity in liver plasma membranes from lean and genetically diabetic (db/db)

1991 • 15 citations

Phosphatidylcholine could be the source of 1,2-DAG which activates protein kinase C in EGF-stimulated colon carcinoma cells (HT29)

1995 • 13 citations

Pleiotypic responses: regulation by programmable messengers or by multiple receptors?

1986 • 12 citations

Treatment of intact hepatocytes with synthetic diacyl glycerols mimics the ability of glucagon to cause the desensitization of adenylate cyclase

1991 • 7 citations

Analysis of the adenylate cyclase signalling system, and alterations induced by culture with insulin, in a novel SV40-DNA-immortalized hepatocyte cell line (P9 cells)

1994 • 6 citations

Phosphorylation of Heterotrimeric G-Protein

1993 • 3 citations