Cytoprotective effects of adrenomedullin in glomerular cell injury: Central role of cAMP signaling pathway

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Ultrasensitivity in the mitogen-activated protein kinase cascade.

1996 • 1,200 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

The Kidney: Physiology and Pathophysiology.

1985 • 665 citations

The respiratory burst oxidase.

1994 • 608 citations

Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma

1994 • 585 citations

Endothelial Cells Actively Synthesize and Secrete Adrenomedullin

1994 • 582 citations

The ins and outs of Raf kinases

1994 • 537 citations

Inflammation: Basic Principles and Clinical Correlates

1993 • 518 citations

A role for oxygen radicals as second messengers

1991 • 494 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

Interleukin-1, Tumor Necrosis Factor and Lipopolysaccharide Additively Stimulate Production of Adrenomedullin in Vascular Smooth Muscle Cells

1995 • 336 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

Endothelins: multifunctional renal peptides.

1993 • 306 citations

Interleukin 1-α and tumor necrosis factor-α induce oxygen radical production in mesangial cells

1990 • 286 citations

The glomerular response to injury: Progression or resolution?

1994 • 230 citations

Renal localization and actions of adrenomedullin: a natriuretic peptide

1995 • 229 citations

The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells

1993 • 222 citations

Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells.

1994 • 216 citations

Negative Regulation of Raf-1 by Phosphorylation of Serine 621

1996 • 215 citations

Expression of raf family proto-oncogenes in normal mouse tissues.

1990 • 194 citations

Hypertrophic Agonists Stimulate the Activities of the Protein Kinases c-Raf and A-Raf in Cultured Ventricular Myocytes

1995 • 176 citations

Multiple intracellular MAP kinase signaling cascades

1996 • 173 citations

Adrenomedullin Suppresses Mitogenesis in Rat Mesangial Cells via cAMP Pathway

1995 • 154 citations

Adrenomedullin as a Novel Antimigration Factor of Vascular Smooth Muscle Cells

1995 • 152 citations

Functional expression of NADPH oxidase components (alpha- and beta-subunits of cytochrome b558 and 45-kDa flavoprotein) by intrinsic human glomerular mesangial cells.

1991 • 146 citations

Reactive oxygen species and neutrophil respiratory burst cytochrome b558 are produced by kidney glomerular cells in passive Heymann nephritis.

1993 • 142 citations

Characterization of cAMP-dependent inhibition of LPS-induced TNFα production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor

1994 • 136 citations

Effects of vasoactive substances and cAMP related compounds on adrenomedullin production in cultured vascular smooth muscle cells

1995 • 125 citations

Inhibition of Rap1A Binding to Cytochrome b ₅₅₈ of NADPH Oxidase by Phosphorylation of Rap1A

1991 • 120 citations

Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils.

1991 • 119 citations

Adrenomedullin Inhibits the Secretion of Cytokine-Induced Neutrophil Chemoattractant, a Member of the Interleukin-8 Family, from Rat Alveolar Macrophages

1995 • 105 citations

Differential inhibition of human neutrophil functions

1990 • 95 citations

Hormonal regulation of rat adrenomedullin gene in vasculature.

1995 • 82 citations

Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV.

1996 • 75 citations

Inhibitors of cyclic nucleotide phosphodiesterase isozymes type-III and type-IV suppress mitogenesis of rat mesangial cells.

1995 • 70 citations

Immunohistochemical localization of adrenomedullin in canine heart and aorta

1995 • 64 citations

Compartmentalization of cAMP Signaling in Mesangial Cells by Phosphodiesterase Isozymes PDE3 and PDE4 REGULATION OF SUPEROXIDATION AND MITOGENESIS

1997 • 63 citations

The effect of cyclic AMP and cyclic GMP phosphodiesterase inhibitors on the superoxide burst of guinea‐pig peritoneal macrophages

1993 • 61 citations

Cytokines, mesangial cell activation and glomerular injury.

1993 • 42 citations

Stimulation of cyclic adenosine monophosphate formation by the novel vasorelaxant peptide adrenomedullin in cultured rat mesangial cells

1995 • 42 citations

Interaction of Adrenomedullin and Platelet-Derived Growth Factor on Rat Mesangial Cell Production of Endothelin

1996 • 40 citations

Formation of reactive oxygen metabolites in glomeruli is suppressed by inhibition of cAMP phosphodiesterase isozyme type IV

1994 • 39 citations

Cyclic ADP-ribose metabolism in rat kidney: High capacity for synthesis in glomeruli

1997 • 24 citations

Oxidant Mechanisms in Glomerulonephritis

1991 • 22 citations