Viruses and Apoptosis: Meddling with Mitochondria

The biochemistry of apoptosis

2000 • 7,314 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Mitochondrial control of cell death

2000 • 3,098 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

The mitochondrion in apoptosis: how Pandora's box opens

2001 • 1,035 citations

Breaking the mitochondrial barrier

2001 • 947 citations

Viral Subversion of the Immune System

2000 • 833 citations

Viruses and Apoptosis

1999 • 744 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 670 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

1999 • 659 citations

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.

1993 • 602 citations

The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability

2000 • 493 citations

The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

2000 • 449 citations

A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2

1999 • 422 citations

Apoptosis: an innate immune response to virus infection

1999 • 409 citations

HIV-1 Protein Tat Induces Apoptosis of Hippocampal Neurons by a Mechanism Involving Caspase Activation, Calcium Overload, and Oxidative Stress

1998 • 400 citations

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

2001 • 324 citations

Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins

2000 • 321 citations

Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB

1999 • 319 citations

Viruses and apoptosis.

1998 • 314 citations

Mechanisms of HIV-associated lymphocyte apoptosis

2000 • 309 citations

Hepatitis B Virus X Protein Colocalizes to Mitochondria with a Human Voltage-Dependent Anion Channel, HVDAC3, and Alters Its Transmembrane Potential

2000 • 306 citations

Granzyme B–Mediated Cytochrome C Release Is Regulated by the Bcl-2 Family Members Bid and Bax

2000 • 306 citations

Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway

2000 • 293 citations

Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2

2001 • 269 citations

Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner

1998 • 245 citations

CAR1, a TNFR–Related Protein, Is a Cellular Receptor for Cytopathic Avian Leukosis–Sarcoma Viruses and Mediates Apoptosis

1996 • 236 citations

Bax, Bid and the permeabilization of the mitochondrial outer membrane in apoptosis

2000 • 227 citations

Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types.

1999 • 209 citations

TNF-α Signals Apoptosis through a Bid-Dependent Conformational Change in Bax that Is Inhibited by E1B 19K

2000 • 196 citations

Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death

1999 • 183 citations

X Protein of Hepatitis B Virus Inhibits Fas-mediated Apoptosis and Is Associated with Up-regulation of the SAPK/JNK Pathway

2001 • 168 citations

Heat-shock proteins as death determinants

2000 • 162 citations

Epstein-Barr Virus Encodes a Novel Homolog of thebcl-2Oncogene That Inhibits Apoptosis and Associates with Bax and Bak

1999 • 158 citations

An endoplasmic reticulum-specific stress-activated caspase (caspase-12) is implicated in the apoptosis of A549 epithelial cells by respiratory syncytial virus

2000 • 153 citations

Glycoprotein D or J Delivered intransBlocks Apoptosis in SK-N-SH Cells Induced by a Herpes Simplex Virus 1 Mutant Lacking Intact Genes Expressing Both Glycoproteins

2000 • 145 citations

Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene

1997 • 131 citations

M11l

2000 • 131 citations

Expression of the Myxoma Virus Tumor Necrosis Factor Receptor Homologue and M11L Genes Is Required to Prevent Virus-Induced Apoptosis in Infected Rabbit T Lymphocytes

1996 • 116 citations

Apoptosis Enhancement by the HIV-1 Nef Protein

2001 • 102 citations

The Chicken Anemia Virus-Derived Protein Apoptin Requires Activation of Caspases for Induction of Apoptosis in Human Tumor Cells

2000 • 100 citations

The Sequence and Antiapoptotic Functional Domains of the Human Cytomegalovirus UL37 Exon 1 Immediate Early Protein Are Conserved in Multiple Primary Strains

2001 • 99 citations

Mitochondrial targeting of the p13II protein coded by the x-II ORF of human T-cell leukemia/lymphotropic virus type I (HTLV-I)

1999 • 95 citations

Mitochondrial Control of Cell Death Induced by HIV‐1‐Encoded Proteins

2000 • 83 citations

Apoptosis Induced by a Postbinding Step of Vaccinia Virus Entry into Chinese Hamster Ovary Cells

1998 • 77 citations

Antiapoptotic Activity of the Herpesvirus Saimiri-Encoded Bcl-2 Homolog: Stabilization of Mitochondria and Inhibition of Caspase-3-Like Activity

1998 • 77 citations

Susceptibility of HIV-1-TAT transfected cells to undergo apoptosis. Biochemical mechanisms

1999 • 76 citations

Inhibitory role of the host apoptogenic gene PKR in the establishment of persistent infection by encephalomyocarditis virus in U937 cells

1999 • 75 citations

Partial Activation and Induction of Apoptosis in CD4⁺and CD8⁺T Lymphocytes by Conformationally Authentic Noninfectious Human Immunodeficiency Virus Type 1

2001 • 75 citations

Ultrastructural localization of BHRF1: an Epstein-Barr virus gene product which has homology with bcl-2.

1994 • 72 citations

Caspase Activation by Adenovirus E4orf4 Protein Is Cell Line Specific and Is Mediated by the Death Receptor Pathway

2001 • 70 citations

Dual Role of the HIV-1 Vpr Protein in the Modulation of the Apoptotic Response of T Cells

2000 • 60 citations

Bcl-2 Blocks a Caspase-Dependent Pathway of Apoptosis Activated by Herpes Simplex Virus 1 Infection in HEp-2 Cells

2000 • 59 citations

Interaction of E1B 19K with Bax is required to block Bax-induced loss of mitochondrial membrane potential and apoptosis

1998 • 58 citations

Human papillomavirus (HPV) 16 E6 sensitizes cells to atractyloside-induced apoptosis: Role of p53, ICE-like proteases and the mitochondrial permeability transition

1997 • 42 citations

Wild-Type Herpes Simplex Virus 1 Blocks Programmed Cell Death and Release of Cytochrome c but Not the Translocation of Mitochondrial Apoptosis-Inducing Factor to the Nuclei of Human Embryonic Lung Fibroblasts

2000 • 40 citations

Stress responses to viral infection

1994 • 34 citations

p53 and tumour viruses: Catching the guardian off-guard

1997 • 33 citations

The p13^IIProtein of HTLV Type 1: Comparison with Mitochondrial Proteins Coded by Other Human Viruses

2000 • 23 citations

Viral proteins and the mitochondrial apoptotic checkpoint

2001 • 19 citations