p53 and tumour viruses: Catching the guardian off-guard

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

Transgenic mice harboring SV40 t-antigen genes develop characteristic brain tumors

1984 • 492 citations

Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

1981 • 491 citations

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.

1996 • 346 citations

HLA DR–DQ associations with cervical carcinoma show papillomavirus–type specificity

1994 • 329 citations

Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours

1992 • 313 citations

Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma.

1993 • 307 citations

Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage

1995 • 291 citations

Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

1994 • 283 citations

Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation

1995 • 250 citations

p53 Protein Exhibits 3′-to-5′ Exonuclease Activity

1996 • 248 citations

Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells

1991 • 248 citations

Functional and physical interaction between p53 and BZLF1: implications for Epstein-Barr virus latency.

1994 • 242 citations

p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines

1993 • 242 citations

Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo

1995 • 240 citations

Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.

1995 • 234 citations

Inhibition of p53 DNA binding by human papillomavirus E6 proteins

1994 • 214 citations

The association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer

1995 • 198 citations

The Epstein-Barr virus bZIP transcription factor Zta causes G0/G1 cell cycle arrest through induction of cyclin-dependent kinase inhibitors.

1996 • 182 citations

Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virusX gene

1996 • 182 citations

Inhibition of viral and cellular promoters by human wild-type p53

1992 • 178 citations

Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex

1986 • 175 citations

Human papilloma virus and p53 in head and neck cancer: clinical correlates and survival.

1996 • 165 citations

Functional p53 protein in human papillomavirus-positive cancer cells.

1995 • 146 citations

Targeting frequency for deletion vectors in embryonic stem cells.

1994 • 143 citations

Elevated Wild-Type p53 Protein Levels in Human Epithelial Cell Lines Immortalized by the Human Papillomavirus Type 16 E7 Gene

1994 • 137 citations

Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes

1995 • 126 citations

Viruses and cancer

1991 • 118 citations

SV40 T antigen abrogates p53-mediated transcriptional activity.

1993 • 108 citations

Epstein-Barr virus efficiently immortalizes human B cells without neutralizing the function of p53.

1995 • 106 citations

Mutations of p53 and human papillomavirus infection in cervical carcinoma

1993 • 91 citations

Enhanced Expression of p53 in Human Cella Infected with Mutant Adenoviruses

1994 • 91 citations

Apoptosis Is Induced at Nonpermissive Temperature by a Transient Increase in p53 in Cell Lines Immortalized with Temperature-Sensitive SV40 Large T-Antigen Gene

1994 • 57 citations

Mutant p53 but not hepatitis B virus X protein is present in hepatitis B virus-related human hepatocellular carcinoma.

1995 • 51 citations

Simian virus 40 (SV40)-transgenic mice that develop tumors are specifically tolerant to SV40 T antigen.

1987 • 51 citations

Mutations in the p53 Tumor-Suppressor Gene Are Frequently Associated with Bovine Leukemia Virus-Induced Leukemogenesis in Cattle but Not in Sheep

1995 • 49 citations

The Epstein-Barr virus nuclear antigen leader protein associates with hsp72/hsc73

1995 • 49 citations

Temporal order and functional analysis of mutations within the Fli-1 and p53 genes during the erythroleukemias induced by F-MuLV.

1993 • 42 citations

Hsp70 binds specifically to a peptide derived from the highly conserved domain (I) region of P53

1992 • 41 citations

Resting B-cells, EBV-infected B-blasts and established lymphoblastoid cell lines differ in their Rb, p53 and EBNA-5 expression patterns.

1995 • 38 citations

n-Butyrate, a cell cycle blocker, inhibits the replication of polyomaviruses and papillomaviruses but not that of adenoviruses and herpesviruses

1994 • 38 citations

Stabilization of the tumor suppressor p53 during cellular transformation by simian virus 40: influence of viral and cellular factors and biological consequences

1994 • 38 citations

Large E1B proteins of adenovirus types 5 and 12 have different effects on p53 and distinct roles in cell transformation

1993 • 37 citations

The domain of p53 required for binding HPV 16 E6 is separable from the degradation domain.

1995 • 36 citations

Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins

1993 • 30 citations

Moloney murine leukemia virus-induced lymphomas in p53-deficient mice: overlapping pathways in tumor development?

1996 • 24 citations

p53 mutations are not selected for in simian virus 40 T-antigen-induced tumors from transgenic mice

1992 • 20 citations

E6 and E7 expression from the HPV 18 LCR: development of genital hyperplasia and neoplasia in transgenic mice.

1995 • 17 citations

Dilated heart failure in transgenic mice expressing the Epstein--Barr virus nuclear antigen-leader protein

1993 • 16 citations

Wild-type p53 is not a negative regulator of simian virus 40 DNA replication in infected monkey cells

1993 • 14 citations

Neuroectodermal tumors expressing c-, L-, and N-myc in transgenic mice that carry the E1A/E1B gene of human adenovirus type 12.

1994 • 6 citations