Bax, Bid and the permeabilization of the mitochondrial outer membrane in apoptosis

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

Calcium in Ischemic Cell Death

1998 • 818 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

Conformation of the Bax C-terminus regulates subcellular location and cell death

1999 • 723 citations

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

1999 • 717 citations

Signal transduction of stress via ceramide

1998 • 687 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 670 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells

1999 • 595 citations

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

1999 • 544 citations

Cyclophilin‐D binds strongly to complexes of the voltage‐dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

1998 • 475 citations

Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis

1997 • 428 citations

The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

1999 • 316 citations

Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents.

1997 • 302 citations

Functional Consequences of the Sustained or Transient Activation by Bax of the Mitochondrial Permeability Transition Pore

1999 • 295 citations

Kinetic evidence for a heart mitochondrial pore activated by Ca²⁺, inorganic phosphate and oxidative stress

1988 • 293 citations

Release of cytochrome c and decrease of cytochrome c oxidase in Bax‐expressing yeast cells, and prevention of these effects by coexpression of Bcl‐x_L

1997 • 288 citations

The Mitochondrial F0F1-ATPase Proton Pump Is Required for Function of the Proapoptotic Protein Bax in Yeast and Mammalian Cells

1998 • 273 citations

Bax, but not Bcl-x _L , decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations

1999 • 267 citations

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1991 • 261 citations

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

1996 • 203 citations

Role of mitochondria and C‐terminal membrane anchor of Bcl‐2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae

1996 • 178 citations

Commitment to Apoptosis by GD3 Ganglioside Depends on Opening of the Mitochondrial Permeability Transition Pore

1999 • 166 citations

Apoptogenic Ganglioside GD3 Directly Induces the Mitochondrial Permeability Transition

1999 • 131 citations

Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses

1996 • 127 citations

Cyclosporin A and its nonimmunosuppressive analogue N‐Me‐Val‐4‐cyclosporin A mitigate glucose/oxygen deprivation‐induced damage to rat cultured hippocampal neurons

1999 • 113 citations

Involvement of mitochondrial contact sites in the subcellular compartmentalization of phospholipid biosynthetic enzymes.

1993 • 110 citations

Involvement of contact sites in phosphatidylserine import into liver mitochondria

1991 • 104 citations

A Cytofluorometric Assay of Nuclear Apoptosis Induced in a Cell-Free System: Application to Ceramide-Induced Apoptosis

1997 • 73 citations

Mitochondrial peripheral-type benzodiazepine receptor expression

1999 • 66 citations

Fibrillin: evidence that chondroitin sulphate proteoglycans are components of microfibrils and associate with newly synthesised monomers

1996 • 62 citations

Expression and Purification of Full-Length Human Bax α

1999 • 40 citations