DNA damage induced by tumour necrosis factor-alpha in L929 cells is mediated by mitochondrial oxygen radical formation.

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Evaluation of 2′,7′-Dichlorofluorescin and Dihydrorhodamine 123 as Fluorescent Probes for Intracellular H2O2 in Cultured Endothelial Cells

1993 • 1,126 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

DNA strand scission by enzymically generated oxygen radicals

1981 • 428 citations

The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents.

1993 • 403 citations

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis

1984 • 376 citations

Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro.

1991 • 358 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron salts

1978 • 293 citations

The Involvement of Poly(ADP‐ribose) Polymerase in the Degradation of NAD Caused by γ‐Radiation and N‐Methyl‐N‐Nitrosourea

1979 • 275 citations

Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells

1993 • 272 citations

Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress.

1991 • 247 citations

Mechanisms of cell death

1989 • 237 citations

Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo.

1993 • 232 citations

tert-Butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids

1989 • 222 citations

Tumor Necrosis Factors: Gene Structure and Biological Activities

1986 • 215 citations

Tumour cell killing by tumour necrosis factor: inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism.

1987 • 206 citations

Glutathione measurement by high-performance liquid chromatography separation and fluorometric detection of the glutathione-orthophthalaldehyde adduct

1989 • 199 citations

Ca2+ release from mitochondria induced by prooxidants

1988 • 166 citations

Oxidative damage to mitochondria is mediated by the Ca2+-dependent inner-membrane permeability transition

1993 • 151 citations

Optimal detection of apoptosis by flow cytometry depends on cell morphology

1993 • 127 citations

Analysis of TNF alpha-induced DNA strand breaks at the single cell level.

1991 • 111 citations

Tumor necrosis factor-alpha-mediated decrease in glutathione increases the sensitivity of pulmonary vascular endothelial cells to H2O2.

1992 • 107 citations

Decreased Hepatic Glutathione Levels in Septic Shock

1985 • 97 citations

Target cell DNA fragmentation is mediated by lymphotoxin and tumor necrosis factor.

1987 • 94 citations

Respiratory burst activity in brain macrophages: a flow cytometric study on cultured rat microglia

1991 • 74 citations

Mitochondrial damage and its role in causing hepatocyte injury during stimulation of lipid peroxidation by iron nitriloacetate

1992 • 64 citations

Cyclosporine a inhibits mitochondrial pyridine nucleotide hydrolysis and calcium release

1990 • 60 citations

Intracellular Ca²⁺Chelators Prevent Dna Damage And Protect Hepatoma 1Clc7 Cells From Quinone-Induced Cell Killing

1990 • 27 citations