Distinct requirements for the naturally occurring splice forms Stat4 and Stat4 in IL-12 responses

STATs and Gene Regulation

1997 • 3,927 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer

2001 • 1,297 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.

1988 • 578 citations

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.

1996 • 529 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection

2002 • 476 citations

Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases

1997 • 462 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?

1997 • 381 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.

1995 • 363 citations

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

1996 • 302 citations

T Cell–mediated Pathology in Two Models of Experimental Colitis Depends Predominantly on the Interleukin 12/Signal Transducer and Activator of Transcription (Stat)-4 Pathway, but Is Not Conditional on Interferon γ Expression by T Cells

1998 • 288 citations

Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.

1996 • 281 citations

Requirements for Interleukin-4-Induced Gene Expression and Functional Characterization of Stat6

1996 • 279 citations

Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice

1995 • 273 citations

Naturally Occurring Dominant Negative Variants of Stat5

1996 • 270 citations

Structure of the Amino-Terminal Protein Interaction Domain of STAT-4

1998 • 267 citations

Interacting Regions in Stat3 and c-Jun That Participate in Cooperative Transcriptional Activation

1999 • 224 citations

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

2001 • 222 citations

STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation

2002 • 202 citations

Function of Stat2 Protein in Transcriptional Activation by Alpha Interferon

1996 • 169 citations

Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of Stat1

1996 • 153 citations

Interleukin-12 Receptor/STAT4 Signaling Is Required for the Development of Autoimmune Myocarditis in Mice by an Interferon-γ–Independent Pathway

2001 • 148 citations

Functional Differences between Stat3α and Stat3β

1997 • 145 citations

Identification of SH2-Bβ as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2

1999 • 140 citations

Specific Ablation of Stat3β Distorts the Pattern of Stat3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock

2002 • 137 citations

Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity

2000 • 122 citations

A small amphipathic alpha -helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5

2000 • 121 citations

The p38 Mitogen-Activated Protein Kinase Is Required for IL-12-Induced IFN-γ Expression

2000 • 118 citations

Stat4 Regulates Multiple Components of IFN-γ-Inducing Signaling Pathways

2000 • 114 citations

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway

1999 • 111 citations

Increased Susceptibility of Stat4-Deficient and Enhanced Resistance in Stat6-Deficient Mice to Infection withTrypanosoma cruzi

2000 • 108 citations

Pivotal Role of Signal Transducer and Activator of Transcription (Stat)4 and Stat6 in the Innate Immune Response during Sepsis

2001 • 106 citations

IL-12 Induces IFN Regulating Factor-1 (IRF-1) Gene Expression in Human NK and T Cells

1999 • 96 citations

Identification of STAT4-Dependent and Independent Mechanisms of Resistance toToxoplasma gondii

2000 • 94 citations

Cutting Edge: Differential Expression of Chemokines in Th1 and Th2 Cells Is Dependent on Stat6 But Not Stat4

2000 • 90 citations

Th1 Cells Regulate Hematopoietic Progenitor Cell Homeostasis by Production of Oncostatin M

2002 • 82 citations

Interleukin-12 Induces Expression of Interferon Regulatory Factor-1 via Signal Transducer and Activator of Transcription-4 in Human T Helper Type 1 Cells

1999 • 72 citations

STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis

1999 • 68 citations

Cutting Edge: Differential Requirements for Stat4 in Expression of Glycosyltransferases Responsible for Selectin Ligand Formation in Th1 Cells

2001 • 66 citations

Cytokine-Stimulated T Lymphocyte Proliferation Is Regulated by p27Kip1 1

2000 • 64 citations

Disruption of the STAT4 Signaling Pathway Protects from Autoimmune Diabetes While Retaining Antiviral Immune Competence

1999 • 62 citations

SH2-B Family Members Differentially Regulate JAK Family Tyrosine Kinases

2002 • 61 citations

The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2

1995 • 58 citations

Role of the Stat4 N Domain in Receptor Proximal Tyrosine Phosphorylation

2000 • 58 citations

Role of Interleukin-12 and Stat-4 in the Regulation of Airway Inflammation and Hyperreactivity in Respiratory Syncytial Virus Infection

2001 • 57 citations

Dimer Stability as a Determinant of Differential DNA Binding Activity of Stat3 Isoforms

2000 • 49 citations

A Mandatory Role for STAT4 in IL-12 Induction of Mouse T Cell CCR5

2001 • 35 citations

Cutting Edge: Chandra, a Novel Four-Transmembrane Domain Protein Differentially Expressed in Helper Type 1 Lymphocytes

2000 • 32 citations

Herpesvirus saimiri immortalized gamma delta T cell line activated by IL-12.

1996 • 31 citations

The Homeostasis But Not the Differentiation of T Cells Is Regulated by p27Kip1

2002 • 21 citations