Dimer Stability as a Determinant of Differential DNA Binding Activity of Stat3 Isoforms

Stat3 as an Oncogene

1999 • 2,770 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

1998 • 666 citations

Stat3 Activation Is Required for Cellular Transformation by v-src

1998 • 624 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesisin vivo

2000 • 594 citations

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.

1993 • 543 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

1995 • 423 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

1997 • 370 citations

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.

1995 • 363 citations

Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.

1999 • 315 citations

Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process

1995 • 303 citations

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

1996 • 302 citations

Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype

1996 • 276 citations

Naturally Occurring Dominant Negative Variants of Stat5

1996 • 270 citations

Interacting Regions in Stat3 and c-Jun That Participate in Cooperative Transcriptional Activation

1999 • 224 citations

Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells.

2000 • 212 citations

In vitro activation of Stat3 by epidermal growth factor receptor kinase

1996 • 195 citations

Functional Subdomains of STAT2 Required for Preassociation with the Alpha Interferon Receptor and for Signaling

1997 • 187 citations

Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of Stat1

1996 • 153 citations

Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.

1994 • 150 citations

Cytokines and JAK–STAT Signaling

1999 • 148 citations

Functional Differences between Stat3α and Stat3β

1997 • 145 citations

Cytokines and STATs: How can signals achieve specificity?

1995 • 132 citations

Signaling by the Cytokine Receptor Superfamily^a

1998 • 119 citations

Amino-terminal Signal Transducer and Activator of Transcription (STAT) Domains Regulate Nuclear Translocation and STAT Deactivation

1998 • 118 citations

Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts.

1998 • 109 citations

c-Src Activates the DNA Binding and Transcriptional Activity of Stat3 Molecules: Serine 727 Is Not Required for Transcriptional Activation under Certain Circumstances

1999 • 32 citations