CD8+ T cell efficacy in vaccination and disease

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

2006 • 2,500 citations

Changes in thymic function with age and during the treatment of HIV infection

1998 • 1,887 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

2006 • 1,802 citations

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

2002 • 1,583 citations

T-cell quality in memory and protection: implications for vaccine design

2008 • 1,499 citations

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

2006 • 1,485 citations

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

2007 • 1,346 citations

HIV preferentially infects HIV-specific CD4+ T cells

2002 • 1,246 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

Skewed maturation of memory HIV-specific CD8 T lymphocytes

2001 • 1,025 citations

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

2006 • 1,017 citations

HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

2000 • 990 citations

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

2002 • 986 citations

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

2005 • 916 citations

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

2002 • 912 citations

Effector and Memory CTL Differentiation

2006 • 908 citations

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 • 879 citations

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 • 859 citations

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

2008 • 792 citations

Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

2007 • 700 citations

Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4 ⁺ and CD8 ⁺ T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection

2001 • 693 citations

Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909

2005 • 619 citations

HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

2007 • 581 citations

T Cell Dynamics in HIV-1 Infection

2003 • 571 citations

Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

1996 • 520 citations

Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses

2007 • 487 citations

Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

1996 • 452 citations

Isolation of High Avidity Melanoma-Reactive CTL from Heterogeneous Populations Using Peptide-MHC Tetramers

1999 • 423 citations

Activation of Resting Human Primary T Cells with Chimeric Receptors: Costimulation from CD28, Inducible Costimulator, CD134, and CD137 in Series with Signals from the TCRζ Chain

2004 • 422 citations

High Avidity CTLs for Two Self-Antigens Demonstrate Superior In Vitro and In Vivo Antitumor Efficacy

1999 • 388 citations

Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1–infected subjects with progressive disease: changes after antiretroviral therapy

2003 • 380 citations

Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses

2005 • 374 citations

Preserved CD4+ Central Memory T Cells and Survival in Vaccinated SIV-Challenged Monkeys

2006 • 373 citations

COOPERATION BETWEEN CD4⁺AND CD8⁺T CELLS: When, Where, and How

2006 • 365 citations

Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection

2002 • 363 citations

Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

1997 • 344 citations

Telomere Length of Transferred Lymphocytes Correlates with In Vivo Persistence and Tumor Regression in Melanoma Patients Receiving Cell Transfer Therapy

2005 • 331 citations

Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes

2006 • 315 citations

Direct Link Between mhc Polymorphism, T Cell Avidity, and Diversity in Immune Defense

2002 • 315 citations

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response

2005 • 313 citations

Insufficient Production and Tissue Delivery of CD4+Memory T Cells in Rapidly Progressive Simian Immunodeficiency Virus Infection

2004 • 303 citations

An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses

2008 • 299 citations

The microbial mimic poly IC induces durable and protective CD4⁺T cell immunity together with a dendritic cell targeted vaccine

2008 • 291 citations

Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates

2006 • 279 citations

T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV Infection

2004 • 279 citations

Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines

2005 • 275 citations

Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression

2007 • 262 citations

HIV Infection Rapidly Induces and Maintains a Substantial Suppression of Thymocyte Proliferation

2004 • 254 citations

Spatial and Temporal Dynamics of T Cell Receptor Signaling with a Photoactivatable Agonist

2007 • 240 citations

Immunisation with BCG and recombinant MVA85A induces long‐lasting, polyfunctional Mycobacterium tuberculosis‐specific CD4⁺ memory T lymphocyte populations

2007 • 226 citations

Selection of T Cell Clones Expressing High-Affinity Public TCRs within Human Cytomegalovirus-Specific CD8 T Cell Responses

2005 • 224 citations

Subdominant CD8⁺T-Cell Responses Are Involved in Durable Control of AIDS Virus Replication

2007 • 217 citations

High-Avidity CTL Exploit Two Complementary Mechanisms to Provide Better Protection Against Viral Infection Than Low-Avidity CTL

2001 • 207 citations

Hierarchies in Cytokine Expression Profiles for Acute and Resolving Influenza Virus-Specific CD8+ T Cell Responses: Correlation of Cytokine Profile and TCR Avidity

2004 • 203 citations

A Novel Approach to the Analysis of Specificity, Clonality, and Frequency of HIV-Specific T Cell Responses Reveals a Potential Mechanism for Control of Viral Escape

2002 • 203 citations

Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge

2006 • 187 citations

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection

2006 • 186 citations

Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma.

2003 • 175 citations

PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status

2007 • 169 citations

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR

2007 • 164 citations

Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses

2006 • 159 citations

New Generation Vaccine Induces Effective Melanoma-Specific CD8+ T Cells in the Circulation but Not in the Tumor Site

2006 • 151 citations

Multiple Costimulatory Modalities Enhance CTL Avidity

2005 • 145 citations

Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection

2005 • 142 citations

Impact of vaccine-induced mucosal high-avidity CD8+CTLs in delay of AIDS viral dissemination from mucosa

2005 • 140 citations

A Shift in the Phenotype of Melan-A-Specific CTL Identifies Melanoma Patients with an Active Tumor-Specific Immune Response

2000 • 138 citations

Heterogeneous T-cell response to MAGE-A10(254-262): high avidity-specific cytolytic T lymphocytes show superior antitumor activity.

2001 • 134 citations

Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen

2008 • 134 citations

The Functional Profile of Primary Human Antiviral CD8+ T Cell Effector Activity Is Dictated by Cognate Peptide Concentration

2004 • 132 citations

Prime–boost immunization generates a high frequency, high-avidity CD8+ cytotoxic T lymphocyte population

2002 • 120 citations

Selective Induction of High Avidity CTL by Altering the Balance of Signals from APC

2003 • 120 citations

Repertoire, diversity, and differentiation of specific CD8 T cells are associated with immune protection against human cytomegalovirus disease

2005 • 118 citations

Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8 ⁺ T Cells after Early HIV-1 Infection

2007 • 115 citations

Antigen Density Presented By Dendritic Cells In Vivo Differentially Affects the Number and Avidity of Primary, Memory, and Recall CD8+ T Cells

2003 • 113 citations

Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection.

1992 • 107 citations

In vivo activation of melanoma-specific CD8+ T cells by endogenous tumor antigen and peptide vaccines. A comparison to virus-specific T cells

2002 • 105 citations

A Novel Functional CTL Avidity/Activity Compartmentalization to the Site of Mucosal Immunization Contributes to Protection of Macaques against Simian/Human Immunodeficiency Viral Depletion of Mucosal CD4+ T Cells

2007 • 104 citations

A viral CTL escape mutation leading to immunoglobulin-like transcript 4–mediated functional inhibition of myelomonocytic cells

2007 • 101 citations

Human Immunodeficiency Virus-1 Infection Interrupts Thymopoiesis and Multilineage Hematopoiesis In Vivo

1998 • 99 citations

Clonal Selection, Clonal Senescence, and Clonal Succession: The Evolution of the T Cell Response to Infection with a Persistent Virus

2002 • 97 citations

Diversity and Recognition Efficiency of T Cell Responses to Cancer

2004 • 96 citations

In Vivo Induction of a High-Avidity, High-Frequency Cytotoxic T-Lymphocyte Response Is Associated with Antiviral Protective Immunity

2000 • 94 citations

Multifunctional Human Immunodeficiency Virus (HIV) Gag-Specific CD8⁺T-Cell Responses in Rectal Mucosa and Peripheral Blood Mononuclear Cells during Chronic HIV Type 1 Infection

2007 • 91 citations

Peptide Requirement for CTL Activation Reflects the Sensitivity to CD3 Engagement: Correlation with CD8αβ Versus CD8αα Expression

2001 • 91 citations

Quiescent phenotype of tumor-specific CD8+ T cells following immunization

2004 • 86 citations

Antigen–specific release of β-chemokines by anti-HIV-1 cytotoxic T lymphocytes

1998 • 83 citations

Mucosal HIV-1 Pox Virus Prime-Boost Immunization Induces High-Avidity CD8+ T Cells with Regime-Dependent Cytokine/Granzyme B Profiles

2007 • 79 citations

Epitope-Dependent Avidity Thresholds for Cytotoxic T-Lymphocyte Clearance of Virus-Infected Cells

2007 • 69 citations

A Novel Approach to Characterize Clonality and Differentiation of Human Melanoma-Specific T Cell Responses: Spontaneous Priming and Efficient Boosting by Vaccination

2006 • 68 citations

The T cell repertoire in infection and vaccination: implications for control of persistent viruses

2007 • 67 citations

Cutting Edge: Predetermined Avidity of Human CD8 T Cells Expanded on Calibrated MHC/Anti-CD28-Coated Microspheres

2003 • 62 citations

Selective Growth, In Vitro and In Vivo, of Individual T Cell Clones from Tumor-Infiltrating Lymphocytes Obtained from Patients with Melanoma

2004 • 51 citations

Avidity of CD8 T cells sharpens immunodominance

2007 • 41 citations

Cutting Edge: CD8+ T Cell Clones Possess the Potential to Differentiate into both High- and Low-Avidity Effector Cells

2007 • 41 citations

Secondary immunisation with high‐dose heterologous peptide leads to CD8 T cell populations with reduced functional avidity

2007 • 23 citations

Decreased specific CD8⁺ T cell cross‐reactivity of antigen recognition following vaccination with Melan‐A peptide

2006 • 17 citations