PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Restoring function in exhausted CD8 T cells during chronic viral infection

2005 • 3,743 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 • 2,521 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

2006 • 1,485 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

2007 • 1,416 citations

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

2006 • 859 citations

Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load

2004 • 787 citations

The PD-1–PD-L pathway in immunological tolerance

2006 • 681 citations

PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 • 646 citations

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

2003 • 594 citations

Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency.

1997 • 560 citations

PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

2006 • 558 citations

Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort Study.

1993 • 452 citations

Programmed Death-1 (PD-1) is a Marker of Germinal Center-associated T Cells and Angioimmunoblastic T-Cell Lymphoma

2006 • 343 citations

Human CD8+ T-cell differentiation in response to viruses

2003 • 299 citations

T-cell tolerance or function is determined by combinatorial costimulatory signals

2006 • 229 citations

New regulatory co-receptors: inducible co-stimulator and PD-1

2002 • 227 citations

Normal Human CD4+ Memory T Cells Display Broad Heterogeneity in Their Activation Threshold for Cytokine Synthesis

1998 • 202 citations

Persistent numbers of tetramer+ CD8+ T cells, but loss of interferon-γ+ HIV-specific T cells during progression to AIDS

2002 • 186 citations

High viral burden in the presence of major HIV-specific CD8+ T cell expansions: evidence for impaired CTL effector function

2001 • 185 citations

CTLA-4 Regulates Tolerance Induction and T Cell Differentiation In Vivo

1998 • 174 citations

Expression and Function of CTLA-4 in Th1 and Th2 Cells

1998 • 161 citations

Dynamics of T Cell Responses in HIV Infection

2002 • 145 citations

Lessons from the study of T-cell differentiation in persistent human virus infection

2004 • 138 citations

The assessment of antigen-specific CD8+ T cells through the combination of MHC class I tetramer and intracellular staining

2002 • 105 citations

PD-1/PD-L pathway and autoimmunity

2005 • 97 citations

CD38 Expression on CD8 T Lymphocytes as a Marker of Residual Virus Replication in Chronically HIV-Infected Patients Receiving Antiretroviral Therapy

2004 • 95 citations

Relationship between the frequency of HIV-specific CD8⁺T cells and the level of CD38⁺CD8⁺T cells in untreated HIV-infected individuals

2004 • 63 citations

Directex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8+ T lymphocyte activation in response to therapeutic manipulation of virus load

2001 • 27 citations

Evaluation of HIV-1 p24 Antigenemia and Level of CD8+CD38+ T cells as Surrogate Markers of HIV-1 RNA Viral Load in HIV-1-Infected Patients in Dakar, Senegal

2006 • 18 citations

Preferential retroviral-mediated transduction of EBV- and CMV-specific T cells after polyclonal T-cell activation

2004 • 7 citations