HIV Infection Rapidly Induces and Maintains a Substantial Suppression of Thymocyte Proliferation

Changes in thymic function with age and during the treatment of HIV infection

1998 • 1,887 citations

A Direct Estimate of the Human αβ T Cell Receptor Diversity

1999 • 893 citations

CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?

2002 • 458 citations

T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)

2000 • 448 citations

Two Subsets of Naive T Helper Cells with Distinct T Cell Receptor Excision Circle Content in Human Adult Peripheral Blood

2002 • 442 citations

Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

2000 • 404 citations

T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock

2000 • 392 citations

p27Kip1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells

1999 • 352 citations

Turnover of CD4+ and CD8+ T Lymphocytes in HIV-1 Infection as Measured by Ki-67 Antigen

1998 • 337 citations

T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation

2001 • 327 citations

Continued maturation of thymic emigrants in the periphery

2004 • 295 citations

Evidence for Increased T Cell Turnover and Decreased Thymic Output in HIV Infection

2001 • 260 citations

High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection.

1998 • 256 citations

Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function

2001 • 249 citations

Identification of a human recent thymic emigrant phenotype

2000 • 243 citations

Direct Evidence for Thymic Function in Adult Humans

1999 • 236 citations

Pleiotropic changes controlled by the pre-T-cell receptor

1999 • 199 citations

T-Cell Receptor α Locus V(D)J Recombination By-Products Are Abundant in Thymocytes and Mature T Cells

1996 • 195 citations

Premature ageing of the immune system: the cause of AIDS?

2002 • 173 citations

T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool

1999 • 172 citations

A central role for thymic emigrants in peripheral T cell homeostasis

1999 • 167 citations

T Cell Homeostasis

2001 • 163 citations

Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus.

1989 • 162 citations

Effects of exogenous interleukin-7 on human thymus function

2002 • 143 citations

Disrupting T-cell homeostasis: how HIV-1 infection causes disease.

2003 • 136 citations

Peripheral Selection of T Cell Repertoires: The Role of Continuous Thymus Output

1997 • 134 citations

Surface Expression of Notch1 on Thymocytes: Correlation with the Double-Negative to Double-Positive Transition

2003 • 107 citations

Effect of recent thymic emigrants on progression of HIV-1 disease

2000 • 101 citations

Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function

2004 • 100 citations

Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease

2003 • 81 citations

Immune reconstitution in HIV-1-infected children on antiretroviral therapy: role of thymic output and viral fitness

2002 • 73 citations

Quantification of T cell receptor rearrangement excision circles to estimate thymic function: an important new tool for endocrine-immune physiology

2003 • 64 citations

De novo T-cell generation in patients at different ages and stages of HIV-1 disease

2004 • 48 citations

Dynamics of fine T-cell subsets during HIV disease and after thymic ablation by mediastinal irradiation

1997 • 46 citations

T cell receptor excision circle (TREC) content following maximum HIV suppression is equivalent in HIV-infected and HIV-uninfected individuals

2001 • 43 citations

Analysis of telomere length and thymic output in fast and slow/non-progressors with HIV infection

2000 • 29 citations

T‐Cell Receptor Excisional Circles, Telomere Length, Proliferation and Apoptosis in Peripheral Blood Mononuclear Cells of Human Immunodeficiency Virus‐Infected Individuals after 18 Months of Treatment Induced Viral Suppression

2003 • 13 citations

Immune reconstitution in HIV-infected children on antiretroviral therapy

2005 • 2 citations